[akt1]

Hi,


Can pois be all about too much GLUTAMATE?

Glutamate is a exitatory neurotransmitter (you get "jacked up").
In a healthy person Glutamate should be converted into GABA ( the inihibitory/calming neurotransmitter).

But the enzyme that does this (glutamate decarboxylase) needs to be working! it does not work for everyone ( for example mthfr-mutation can defect it).

Things that regulate/lower Glutamate are:
CBD, Ginger, Niacin(?), Taurine and NAC.... And methylated vitamin b-s.

An most people with pois seem to get relief from GABA-ergic/GABArelated supplements -> meaning the glutamate has not converted into GABA...?


Do people with pois have a defect Glutamate-GABA-conversion?

GLUTAMATE seems to raise 300% in rats during ejaculation?
https://www.jneurosci.org/content/26/6/1699


What if it does not get converted into GABA....? - then you get "jacked/doped up"!?

Symptoms of too much Glutamate:
https://area1255-portal2.blogspot.com/2016/04/symptoms-of-high-glutamate-levels-in.html


To lower GLUTAMATE and turn it into GABA Check out:
Cbd, Taurine, methylated/active vitamin B-s and especially NAC (?)


We got this....
Hoping to finish this
Disease...!

Check out defect glutamate-gaba-conversion mates...

peace and bless!
akt1

[akt1]

Hi,


Can pois be all about too much GLUTAMATE?

Glutamate is a exitatory neurotransmitter (you get "jacked up").
In a healthy person Glutamate should be converted oin to GABA ( the inihibitory/calming neurotransmitter).

But the enzyme that does this (glutamate decarboxylase) needs to be working! it does not work for everyone ( for example mthfr-mutation can defect it).

Things that regulate/lower Glutamate are:
CBD, Ginger, Niacin(?), Taurine and NAC.... And methylated vitamin b-s.


Do people with pois have a defect Glutamate-GABA-conversion?

GLUTAMATE seems to raise 300% in rats during ejaculation?
https://www.jneurosci.org/content/26/6/1699


What if it does not get converted into GABA....? - then you get "jacked/doped up"!?

Symptoms of too much Glutamate:
https://area1255-portal2.blogspot.com/2016/04/symptoms-of-high-glutamate-levels-in.html


To lower GLUTAMATE and turn it into GABA Check out:
Cbd, Taurine, methylated/active vitamin B-s and especially NAC (?)


We got this....
Hoping to finish this
Disease...!

Check out defect glutamate-gaba-conversion mates...

peace and bless!
akt1

If this theory can get rid of pois i guess then pois can be all about:

1. Making the enzyme Glutamate decarboxylase start working
2. Or lowering glutamate with amino acids like Taurine and/or NAC


... what do you think?
at least then there is something concrete to work on.

I for one get autistic traits and can not socialize from - what i guess is too much glutamate. These traits go away with NAC, Taurine and methyl vitamin b´s.


How do you best lower glutamate and/or make the enzyme Glutamate decarboxylase to start working?


Glutamate -> needs a working -> Glutamate decarboxylase enzyme -> in order to turn Glutamate into -> GABA...


( i think celiac disease/gluten can also disrupt the function of Glutamate decarboxylase which might explain why lchf diet can work for some?)

[akt1]

Glutamate seems to be released during O, and it SHOULD be converted into GABA. Most people with pois get relief from supplements that increase GABA. - The enzyme glutamate decarboxylase might not be working for us (?) - and then glutamate is NOT converted into GABA..

According to this article, Taurine is a good choice for lowering Glutamate and increasing GABA, and making the enzyme work:

"The amino acid taurine increases the GAD enzyme and consequently GABA levels. Additionally, taurine doubles as an inhibitory neurotransmitter and can bind directly to GABA receptors, so it can help provide balance naturally in that manner as well. Higher levels of any inhibitory neurotransmitter help lower high levels of any excitatory neurotransmitter. Taurine is found in high levels in the brain and cardiac tissue, indicating its importance in these areas. Taurine is found most abundantly in seafood and animal protein, so it is often deficient in one’s diet."


Too much Glutamate:

"Elevated levels of glutamate trigger the brain to release its natural opioids (endorphins/enkephalins) in order to protect the brain from damage, which can result in feelings of spaciness and eventually contribute to depletion of your natural opioids, and it also depletes glutathione levels, which is vital for detoxification, controlling inflammation and gut health. Additionally, glutathione also assists in protecting neurons from damage, so when it is depleted it is not available to do this job and thus contributes to more cell death. High levels of glutamate may increase the survival of unfriendly microbes in the gut and contribute to problems like excess acid and heartburn. Too much glutamate can lead to too much acetylcholine, and too much acetylcholine has a stimulating effect as well and puts one into a perpetual state of sympathetic stress with high levels of anxiety, fear, insomnia, restlessness, nervousness etc."

https://www.jacobsladdercenter.com/doc/research/other/How-to-Increase-GABA-and-Balance-Glutamate.pdf

[akt1]

Is pois because of poor methylation issues?
Can we not convert Glutamate into GABA?

To get normal methylation and  GLUTAMATE into GABA conversion going, check out:

1. Methylated vitamin b-s (for example Jarrow b-right)
2. NAC
3. Taurine


Anyone else tried the above against pois?

Is it all because of MTHFR-mutation?

In case one does not want to use supplements - can any diet fix these issues it the above is the problem?

peace

[demografx]

Our POIS Research Team




Dr. Tierney Lorenz, our Primary Investigator



Dr. Nicole Prause, our Co-Investigator




The POIS data will be collected at Dr. Prause’s lab (Liberos LLC) in Los Angeles, but both Dr. Lorenz and Dr. Prause will be analyzing it.


For more POIS Grant info:
https://tinyurl.com/y9bqtmam
[/quote]

Please visit & explore!
NO RUSH. But please fill out this  form to see if you qualify!
www.liberoscenter.com/POIS


For additional info, visit our thread at:
https://poiscenter.com/forums/index.php?topic=3006.msg33041#msg33041

[B_Daniel]

Hi akt1.  I'm appreciative of your well thought out theory.  Many people on the forum, including myself, have had success with many of the supplements which convert Glutamate to Gaba.  However I believe this is coincidental, because at least in my case, this theory doesn't hold water.

For starters, I used to take gaba pills.  For months I took them.  Didn't help my pois, however I liked the way it calmed me.

Even if gaba doesn't help me, your theory could still apply to too much Glutamate.  However this doesn't work for me either
1) From everything I can see, my methylation appears to be optimal.  I've performed blood work, looked at my genes, etc.  Overall, I've thoroughly researched and reviewed my methylation pathways, and this is not a weakness of mine. 
2) High glutamate would lead to a racing mind and insomnia.  POIS has a nearly opposite effect in me.  It makes me lethargic and clears my mind of all thought and then blocks my ability to think much at all. 

Perhaps others have a different take?

[demografx]

Hi, B_Daniel!

[B_Daniel]

Hi, Demo!
---------------------------

Recently, I've begun to believe that my symptoms align more closely with Chronic Fatigue Syndrome "CFS", than with POIS. 

When I was 20, simply abstaining from sexual activity for a few days would have me feeling like a new person.  But from about 24 and onwards, there has always been some degree of the flu-like symptoms that lingered.  I'm 36 now.  Sex still heightens my brain fog, lethargy, anxiety, etc.  But the symptoms never disappear.

The main symptom I have, if I were to narrow it down to just one, is my lack of energy.  Some days are better than others, but on the whole, I wear out quicker when taking on stress and need more rest periods throughout the day than the avg person.  If I push myself too hard (can be mental or physical stress), I'll crash and be a zombie the next day. 

I think I initially latched on to POIS as an explanation bc of how clear the connection was.  1-3 hours after sex, I felt awful nearly every time.  But I'm now thinking that sex is just a very concentrated way of depleting my energy.  And all forms of that push me over the edge.

Those with CFS often have low testosterone, gastro issues, and sensitivities to certain foods like wheat dairy and soy.  Treatments that help include TRT/HRT, NSAIDs, LDN, B Vitamins, Magnesium and a few other supplements.  So it's similar to what many have said have helped for POIS. 

What I like most about characterizing my illness as CFS is that it's easier to talk to others about (physicians, family members), and there is a larger body of research, more established treatments, and a larger community to lean on.  On the POIS side, we're kinda each inventing the wheel, trying everything under the sun.  In this forum, we've all seen the posts of "If I stand on my head for 30 minutes and then scratch my belly really hard, my POIS goes away".  In the CFS support groups, I haven't seen that.  There's more discussion of the various established treatments. After you've tried those 20 things, you can rest knowing you've tried the bulk of what's likely to help, and then focus on stress reduction and improving your health overall. 
 
Anyway, just wanted to share this, as I view it as a major insight for me.  If I find anything that works for me on the CFS side I'll of course share it over here. 

If this sounds like something you'd like to learn more about, here are a couple of helpful pages I've come across
https://www.healthrising.org/blog/2018/12/10/the-basics-a-guide-to-learning-sharing-and-making-a-difference-in-chronic-fatigue-syndrome-me-cfs/
https://www.healthrising.org/blog/2018/12/01/tips-newbies-fibromyalgia-chronic-fatigue-syndrome-me-cfs/

[chinachin]

This is what I've been looking for, really meaningful

[danireland2]

Hi Guys,

I used to post here under the name "danireland", years and years ago. This site was instrumental in my recovery from POIS symptoms. I just wanted to "give back" and to say what works for me. Hopefully that will help 1 or more other people, and if that happens, that would be awesome.

Just to preface, my symptoms included: run-down feeling, brain fog, diminshed cognitive ability, tiredness, irritability, lack of motivation etc.

Now, 90+% of those symtoms have subsided. I now have a normal sex life. What worked for me?

Mainly NIACIN - the type that enables the FLUSH. The other one doesn't do much for me. I take that on a day that I know I'm going to orgasm. The dosage for me is 1tablet (500mg) on a day I know I'll orgasm. On other days, I don't take it.

Otherwise, having an excellent quality of life helps - good sleep, nutrition, exercise + good mental health is paramount.

I also take a comprehensive multivitamin and I supplement additionally with vitamin C and zinc.

Additionally, in my opinion, frequent ejaculation can lead to the release of higher DHT levels, perhaps a cause of hair loss (an issue with most men, not just POIS sufferers), so I've being adding finasteride, recently - at a low dose (about 0.75 - 1mg, 3 times or so per week).

And, honestly, things are fine. I had sex 3 times last night and orgasmed 3 times, had approx 2 hours sleep, and, I'm fine - thinking clearly and in a good mood. Sure, I might need a nap later, but I'd need that anyway with 2 hours sleep. If this was 10 years ago, I'd be in a far worse state.

Bit of a ramble, there - but I just wanted to give some hope to people out there. I really hope NIACIN can work for you - or something else. It's a nasty feeling having POIS. Def try the FLUSH version of NIACIN, not the non flush variety. I owe a lot to this forum, as, I never would have found the niacin solution, for me. Additionally, try to do all of the other things that put you in an optimum state. At least then, if you're running @ 90% of your optimum state for a day or so post O, you'll still be in a very good position. Anyway, enough ranting - please feel free to email me if you've any questions, as, I would really like to give back, if possible. This site did a lot for me, so thank you to all posters. Take care. Dan Ireland.

[demografx]

Dr. Nicole Prause, Founder, Liberos, LLC

Our POIS Scientific Researcher


POISCenter-funded NORD researcher/co-Investigator (Dr Tierney Lorenz is PI
[Principal Investigator] )

Dr Prause with Sex Positive Me covers the  latest science on Orgasmic Meditation, what POIS (post-orgasmic illness syndrome) is, the physiology of orgasm, and the physical threats to female scientists who try to conduct research in this area:

[raja55]

This last December I had the second worst POIS attack I've experienced (almost exactly one year after the first one, which was the worst). The full force attack came on days 7 and 8: suicidal thoughts, extreme depression, hopelessness, extreme social anxiety, second after second, minute after minute, hour after hour.

On the morning of day 9 I went for a walk and came back to lay down. I felt that somehow isolating myself from people and the walk in nature was helping me. As I was laying down I decided I wouldn't do anything, except being there, laying down.

Suddenly I started feeling very good. I intuitively knew that the POIS was gone, at least for the time being, (not the POIS symptoms, but I felt that the POIS itself was gone). I felt I was was just in the present contemplating and from this present I saw Truths springing forth. I felt assured that I was where I was supposed to be (as new-agey as it may sound), I felt my life was taken care of, I felt that I would remain unshakable for as long as I remained in that state of mind (which lasted a few minutes  and lingered for a couple of hours). I distinctly felt that a sensation in my lower back that usually accompanies me was gone so I thought that this sensation might be related with the POIS.

I had been reading about the theory that POIS might be related to overactive adrenal glands which in turn drops testosterone levels. I realized I live a very active life always being pushed by stress. It occurred to me that POIS was not the sickness, but the cure to my adrenal problem. Possibly, I had been over-active for so long that my body, in it's wisdom, had devised POIS as a means to completely break me down, through POIS, to put a halt to my unhealthy stressed behavior.

I think the POIS is back, or so I "feel". I feel the weird sensation on my lower back and I catch myself acting out of stress and not taking enough rest. But I feel that now I have the upper hand. Every day I become more aware of my stress-based actions and become a bit more calm and happy.

I hope this helps someone. Although it is possible that not all POIS has the same cause, maybe this will resonate with some.

[demografx]

Above post cross-posted:
https://poiscenter.com/forums/index.php?topic=3713.msg39285#msg39285