[Hannah LS (OP)]

Pete asks:

I was wondering, if lions and tigers can interbreed and have ligers, presumably all the big cats interbreed with each other, but could a domestic cat breed with a lion or tiger and what would the result be?

Any thoughts?

[Kryptid]

I don't know if lions and house cats can interbreed (even if they can, artificial insemination would almost certainly be necessary, and you'd want the lion to be the mother). However, you can indeed have many hybrids among the different cat species. House cats can hybridize with margays, margays can hybridize with ocelots, ocelots can hybridize with pumas, pumas can hybridize with leopards and leopards can hybridize with lions. The Messybeast website goes into much detail on these hybrids: http://messybeast.com/genetics/hybrid-cats.htm

[Bored chemist]

If you are talking about "successfully" breeding and the conventional definition of "species" then the answer is none.
Any offspring are infertile.

[evan_au]

Oops! Overlap with Bored Chemist...
One of the important factors in interbreeding is whether the offspring are fertile.
At a coarse level, it is important that the parents have the same number of chromosomes.
- Domestic cat: 38
- Lion: 38
- Tiger: 38

There is more to it than this - the chromosomes need to carry roughly the same genes, in roughly the same locations to produce viable offspring in the second and third generations.
See: https://en.wikipedia.org/wiki/List_of_organisms_by_chromosome_count

[Ophiolite]

If you are talking about "successfully" breeding and the conventional definition of "species" then the answer is none.
Any offspring are infertile.

As an absolute statement this turns out to be incorrect. See https://en.wikipedia.org/wiki/Liger#Fertility

[Bored chemist]

If you are talking about "successfully" breeding and the conventional definition of "species" then the answer is none.
Any offspring are infertile.

As an absolute statement this turns out to be incorrect. See https://en.wikipedia.org/wiki/Liger#Fertility

What do you consider the conventional definition of "species" to be?