[scientizscht (OP)]

Hello!

How can I find the molecular weight of a protein in grams/mol if I know that it's 150kDa?

I read that 1Da = 1g/mol but this is means that 1mol of that protein will weigh 150,000grams or 150kg!

Also, I read that LDL is 3million daltons which means that 1mol of LDL will weigh 3 million grams or 3 tonnes!

But this result says only 386.654 g/mol.
https://www.google.com/search?q=molecular+weight+of+ldl

What is wrong?

Thanks!

[evan_au]

1mol of that protein will weigh 150,000grams or 150kg!

Fortunately, your body doesn't need 1 mole of that protein...

[chiralSPO]

They are both right. Cholesterol is a small molecule with a molecular mass of 387 g/mol (or387 Da). And many proteins have molecular weights of hundreds of kg/mol (KDa)

[scientizscht (OP)]

LDL is 3,000kDa which is 3,000kg/mol. In familial hypercholesterolemia, it reaches 10mmol/L which is 10mmol x 5L = 0,050mol in the whole blood. This is 0.050 x 3,000kg = 150kg!

[Bored chemist]

I suspect that it's LDL measured as the cholesterol contained / combined in the protein.