[Jarek Duda (OP)]

Developing a standard vaccine for coronavirus will take at least a few months - what might be too late.
However, its sequence is already known, and is nearly identical - suggesting recent single point of origin for human host.

So the question is if/how there could be quickly started production of some provisional vaccine - not perfect but fast to introduce? Also exploiting the fact that these viruses are now nearly identical.
For example synthesizing its outside proteins and putting them on liposomes - would its introduction to blood have a chance to prepare immune system for the real virus?

[Hayseed]

The immune system is a very mysterious system to figure out.  With all the intensive research of the last 3 or 4 decades with cancer, aids and other research,  one would think they would have a pretty good catalog of T cells and such.

But apparently not.  Scientists, from England I believe, have found a T cell that directly hunts down and destroys a broad spectrum of cancers.  And I believe they can stimulate it in the body, and the results seem like a miracle. They promise a general population vaccine for it.

So, for a large spectrum of cancers, individual grown anti-bodies will not be necessary.

And other research shows that the largest factor in one's immune system, is the health and variety of gut bacteria.

Along with your daily vitamin or blood pressure pill, you might take a bacteria pill.  Every six months you give a fecal sample and get a new gut prescription.

Maybe in the future, we can find another common avenue, so that virus' don't have to be individually mapped and designed against.

[Jarek Duda (OP)]

Sure, but how does vaccination for viruses work?

Especially if there is a viral envelope, couldn't we just make fake viruses: liposome with built-in virus proteins?
Or some other exposition of immune system to characteristic features of pathogen - to make it more prepared when the real virus strikes?
Any preparation might be a matter of life and death, especially in current coronavirus outbreak ...
Its sequence is already known, this virus seems too uniform now for problems of variety e.g. for flu or HIV ...

[evan_au]

There is an existing prophylactic treatment - it doesn't stop you getting the virus, but it does stop you worrying about getting the virus...

Corona_prophylaxis.jpg (10.22 kB . 199x515 - viewed 16663 times)
PS: This is a joke. Do not take this as a medicine!

[Hayseed]

Both of those posts might help.

I dig what your saying, especially since by the time we get the vaccine to market, the virus can mutate.

Sorta like a blank virus stock, that can be coded as needed.

[Petrochemicals]

The flu vaccine is isolated earlier in the year as the probable strain. This is then cultured in chicken eggs i believe over months!  It doesnt always work, sometimes the wrong strain is selected or there is a more prevelant/dangerous strain emerges. It is reformulated every year. This is about he most impressive, for ebola, I am not sure of the need to reengineer the strain, some sort of genetic splicing vaccine.

https://en.m.wikipedia.org/wiki/RVSV-ZEBOV_vaccine

[Jarek Duda (OP)]

Sure the virus can mutate, but now people's life depends on preparing for the current wave, for which:

"The researchers also found that the eight complete 2019-nCoV genomes were more than 99.98 percent identical, "
https://www.genomeweb.com/genetic-research/coronavirus-genome-sequencing-finds-distinct-genetic-differences-2003-sars-virus

While in a year there might be a serious vaccine, the question here is if there could be quickly made some provisional - to prepare immune system of endangered people for the real virus, e.g. by injecting lisposomes exposing some its proteins?

https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

[Jarek Duda (OP)]

More developed such discussion: https://www.scienceforums.net/topic/121181-provisional-vaccine-for-fast-spreading-new-viruses/

[Petrochemicals]

More developed such discussion: https://www.scienceforums.net/topic/121181-provisional-vaccine-for-fast-spreading-new-viruses/

Seems to say would a dead virus load help ?

[Jarek Duda (OP)]

"Researchers rush to test coronavirus vaccine in people without knowing how well it works in animals" https://www.statnews.com/2020/03/11/researchers-rush-to-start-moderna-coronavirus-vaccine-trial-without-usual-animal-testing/

Good video about mechanisms of COVID-19:

[Jarek Duda (OP)]

From today: https://www.theguardian.com/world/2020/mar/16/first-participant-us-coronavirus-vaccine-trial-moderna-dose

First participant in US coronavirus vaccine trial to be given dose

The first participant in a clinical trial for a vaccine against Covid-19 will receive an experimental dose on Monday, according to a US government official.

The trial, taking place at the Kaiser Permanente Washington Health Research Institute in Seattle, will involve 45 young, healthy volunteers who will be given shots of the vaccine.

[Jarek Duda (OP)]

Imperial Collage predictions for UK - to save lives with vaccine, it is needed by this November: https://www.imperial.ac.uk/news/196234/covid19-imperial-researchers-model-likely-impact/

[Jarek Duda (OP)]

Israeli scientists: 'In a few weeks, we will have coronavirus vaccine'
Once the vaccine is developed, it will take at least 90 days to complete the regulatory process and potentially more to enter the marketplace.

https://www.jpost.com/HEALTH-SCIENCE/Israeli-scientists-In-three-weeks-we-will-have-coronavirus-vaccine-619101

[evan_au]

A friend was watching the TV news, which showed a graph estimating future infections and hospital capacity under various scenarios (probably similar to the one posted by Jarek Duda, above).

The news commentator then parrotted the government's current advice about keeping students in school.
- My friend wondered if the voice-over was actually talking about the same graph that they were showing at the same time...

The graph above (from Jarek) suggests that in the UK, there will be a massive explosion in cases around November-December, as people are indoors during winter months.
- I guess the ideal profile would be to use all the hospital beds at maximum level during the summer months (but not going above the available capacity)
- For Australia, peak viral transmission tends to be May-July, so we expect a somewhat different pattern here.

[Jarek Duda (OP)]

Good discussion about covid19 vaccine development:
https://www.ted.com/talks/seth_berkley_the_quest_for_the_coronavirus_vaccine

A radical approach to speedup:
"Should scientists infect healthy people with the coronavirus to test vaccines?": https://www.nature.com/articles/d41586-020-00927-3

[Jarek Duda (OP)]

https://arstechnica.com/science/2020/05/the-ars-covid-19-vaccine-primer-100-plus-in-the-works-8-in-clinical-trials/

They have at least 102 vaccine candidates in development worldwide. Eight of those have already entered early clinical trials in people. At least two have protected a small number of monkeys from infection with the novel coronavirus, SARS-CoV-2, that causes COVID-19.

Some optimistic vaccine developers say that, if all goes perfectly, we could see large-scale production and limited deployment of vaccines as early as this fall.

[Jarek Duda (OP)]

Coronavirus vaccine for 30 million Britons by September if trial succeeds
Work by the University of Oxford to find an effective drug is "progressing well" but there are no guarantees, warns a minister.

https://news.sky.com/story/coronavirus-covid-19-vaccine-for-30-million-by-september-if-trial-succeeds-says-sharma-11990039