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  4. What is the CKD-EPI equation for eGFR?
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What is the CKD-EPI equation for eGFR?

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Offline jinjon (OP)

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What is the CKD-EPI equation for eGFR?
« on: 16/05/2022 16:27:30 »
Hallo,

I have a question about the 2021 CKD-EPI equation for the estimation of GFR. I have trouble finding the formula of the 2021 CKD-EPI in european units ( creatinine expressed in micromol/Liter etc). Does anybody know this equation or can show me a link where I can see it.

Thanks very much in advance!

« Last Edit: 17/05/2022 22:07:13 by Kryptid »
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Offline evan_au

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Re: What is the CKD-EPI equation for eGFR?
« Reply #1 on: 17/05/2022 12:07:05 »
It looks like this 2021 CKD-EPI equation was developed by the National Kidney Foundation, based in New York. So it would make sense that it uses measures common in the USA.
https://www.kidney.org/

They provide the equation here: https://www.kidney.org/professionals/kdoqi/gfr_calculator/formula
- Some of the units are metric, eg ml,  mg and m2
- Some of the units are semi metric, eg dl
- Some of the metric units are mis-spelled, eg mL & dL
- Some of the units are "convenient" units, like kidney filtration time in minutes and patient age in years
- Some of them are constants which appear to have been derived from some regression analysis, like 142 and 0.9938

So if you want the results in "European" units, you will have to define what those "non-American" units are.
- For example, you could easily calculate patient age in seconds, if you think that is more European/Metric, but I don't think that is a good idea; age in years is a convenient measure
- If you arbitrarily change the units, that may change the constants in non-obvious ways
- So I suggest that if you are quoting a measurement of 2021 CKD-EPI, I suggest that you use the standard units, as that allows you to compare results between countries.

The following website shows the "normal" range, and even lets you compare with earlier versions of the formula:
https://www.mdcalc.com/ckd-epi-equations-glomerular-filtration-rate-gfr#pearls-pitfalls
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Offline evan_au

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Re: CKD-EPI equation for eGFR
« Reply #2 on: 17/05/2022 22:19:52 »
Quote from: OP
2021 CKD-EPI in european units
That is an oxymoron.

If it uses different units for inputs and/or outputs, then the equation will be different, and it is no longer the 2021 CKD-EPI equation.

It is now the jinjon  equation, and since jinjon  does not have the reputation (or published, peer-reviewed papers) of the National Kidney Foundation, no-one will know what that is, and no-one will use it.
So stick to the 2021 CKD-EPI equation, in its original units.

See, for example: https://academic.oup.com/clinchem/article-abstract/68/4/534/6509513?redirectedFrom=fulltext
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