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Offline Andrew K Fletcher

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NEW MULTIPLE SCLEROSIS THEORY
« on: 26/03/2006 20:59:23 »
NEW MULTIPLE SCLEROSIS THEORY

Andrew K Fletcher, "Summer Haze",26 Berry Drive, Paignton, Devon, TQ3 3QW. UK.
E-mail address: Gravity@(remove)blueyonder.co.uk
The purpose of this report, together with the referenced histories, is to inform you of my research and its relationship with multiple sclerosis. But first let me try to explain what I believe multiple sclerosis is, and then perhaps you may begin to understand why I have achieved positive results in treating people with chronic progressive MS.

MULTIPLE SCLEROSIS MAY BE A PROBLEM WITH THE CIRCULATION OF FLUIDS IN OUR BODY.

Brief description of nerve structure:
We call the nerve fibre, which caries the impulses from the nerve body to control the muscles or other functions, the central axon. This fibre is surrounded with a multi-layered sheath with from about five to more than thirty layers. it resembles a large tobacco leaf, coiled around a central trunk, and is produced by a special cell - the oligodendrocyte. The entire group of cells is called the oligodendroglia.
The individual layer of the laminated leaf, which makes up the myelin sheath, is structurally identical with the membrane of a cell. That means it has the capability of holding an electric charge of opposite polarity, thereby fulfilling the function of an electric condenser. We have only understood the function of the myelin sheath in the insulation of the central fibre for about a year. An article that first appeared in the magazine SCIENCE brought it out. Indeed, one can measure the insulating ability of the myelin. When this was done, however, it discovered that the many-layered condenser system, which was constructed in the myelin, acted as an electrical shunt to the central axon. In plain language, this means that we have here a classic Tesla technique, which in all probability converts gravity field energy into the electrical energy necessary for function of the central axon.
Dr. Hans A. Nieper: The Treatment of Multiple Sclerosis Sept 1985

A closer look at nerves:
We have all heard about the fatty insulation around the spinal cord and brain, in which lesions form and cause short circuits, but how many of us have heard that this coating or sheath that protects the nervous system is actually liquid crystal? In fact, it behaves very similar to the substance found in LCD (liquid crystal display) on calculators and wristwatches. Historians now know that some scientists actually saw naturally occurring liquid crystals under their microscopes in the 1850s. These early sightings were made during experiments on the white fatty material known as myelin.

A number of scientists noted that myelin turned liquid when left in water. These liquids seemed to have two different melting points. Not until the 1980s did the answer become apparent. Instead of changing straight into a liquid when heated, these solid materials transform into a kind of intermediate state that emerges at the first melting point, and disappears at the second. Between these two temperatures, the materiel flows like liquid yet keeps some of its optical properties of a solid crystal. In short it has become a "liquid crystal". In a normal liquid molecules are randomly arranged, but the molecules of a warmed liquid crystal retain some of their original orderliness - just enough order for the liquid crystal to retain the optical properties of a solid. Without their liquid crystal structures, living cells could not exist. Although the precise cause of the breakdown of the myelin sheath is still mysterious, it is thought to be tied to the liquid crystal properties of myelin. (Focus November 1994 pages 70-74 by Robert Mathews).

Explanation

The reason that warming liquid assists its ability to dissolve or liquefy soluble minerals is due to the fact that the molecular structure of the liquid, which in this case is water based, is altered by additional heat. The highest alteration before water is vaporised is at boiling point. Boiling water at sea level requires more heat and energy than boiling water at altitude. This is because the atmospheric pressure at high altitude is considerably less than at sea level. In fact when pressure is removed completely within a vacuum chamber, water boils without heat. The Hon. Robert Boyle (1627-91) was first to discover this phenomenon.

An interesting article I read some years ago related to the fact that some people were prone to food poisoning from cooked food when it was prepared at high altitude. Illness occurred because the water, although boiling, was not sufficiently hot enough to kill the bacteria within the food. We of course know that the nervous system does not boil, yet the state of the liquid crystal in the myelin could be encouraged to respond (or re-liquefy) at a slightly lower temperature when exposed to high altitude atmospheric pressure. Oxygen levels at altitude are also greatly reduced in the upper regions of the atmosphere. For instance, the air at Mount Blanc's summit contains only half the oxygen of air at sea level. It is worth considering these two facts while reading the following observations made by two independent accounts. It is also worth considering the fact that a compass needle is attracted to a mountain rather than the pole, due to the mountains mass. Furthermore while standing on top of a mountain the gravitational pull under foot would also be marginally higher and this again, according to my theory, has the most profound implications for circulation throughout the whole of the human anatomy.



Altitude and MS

CASE 1: On two occasions when I have been abroad, sightseeing up mountains, (by cable car and bus I might add!) at the top, anything from 6,000-9,000 ft I have felt fantastic and have been able to walk almost normally. At home I walk with the aid of a stick. This year I was visiting my son in South Africa and where he lives is 3,000 ft. above sea level. Again I had this lovely lightweight feeling instead of my usual heavy and slow moving gait. The old legs were raring to go and I had a spring in my step. The family was amazed and delighted at the difference.
When we went to Durban, which is at sea level, I was back to normal, but it was hotter and humid there. Sad to say, that back home the good affect has gone, but it did seem extraordinary. ? Irene Davies, Glasgow., Sep-Oct 1989 edition, Arms Link, Pub by Arms Central UK.

CASE 2: I have also felt that being at altitude has made me feel very fit and well and improved my walking. I have MS but am mobile and walk without a stick. During 1984/85 my husband worked in Bolivia and I went with him. We lived in La Paz, which is at 11,000 ft and spent time in various places ranging in height from 3,000 to 14,000 ft. The higher we were the better I felt, walking long distances and getting less giddy, which is one of the effects I have with MS.
We were in London from Jan 83 to Mar 84 and I had some difficulty with walking then.
In Bolivia I was able to walk quite far, though down in the low, hot valleys I was not able to go so far as I could up in the high mountains. In Potosi, which is at 14,000 ft, I felt terrific and it was there that I began to think that perhaps altitude made some difference to my health. Once before I had the same feeling of euphoria. This was when I visited the Island Of  The Sun in Lake Titicaca which is at 13,000ft. I felt I could stride out for miles and miles though afterwards I was very tired. This was1974 before I was diagnosed as having MS.
We are now home in Edinburgh, almost at sea level, and most of the time I am able to walk the dogs on the hills and go shopping, though I get giddy at times and especially find the strip lighting in shops troublesome. I get tired more than I used to and I have trouble with my sense of balance. The latter has bothered me for years; again without realising it was part of my MS.
Rosemary Wilson, Edinburgh. Mar/Apr 90 edition, Arms Link, Pub by Arms, Central UK.

Crystals, either in liquid state or solid, are based on minerals. In order to remain in a liquid form the liquid requires to be constantly moving. Should the liquid stagnate for any length of time, solid crystals will inevitably form. This is vividly shown when crystals grow on a length of thread suspended in a beaker of highly concentrated salt or sugar solution. In a beaker this creates no problems. However, when it occurs in the nervous system the formation of crystals causes considerable problems. For instance, a complete blockage of the circulation could occur causing the whole of the circulation within the nervous system in the affected part to stagnate. This would produce considerable damage to the myelin and would probably lead to the entire degeneration of the affected part of the nervous system. Re-dissolving the crystal in the beaker simply requires a stir with a spoon and a little heat to accelerate the process.

The Central and Peripheral Nervous System

If only we could put a whisk into the nervous system and stir gently for a year or more, perhaps the salts and mineral deposits would become liquid again and repair the damaged nerves in multiple sclerosis and other neurological conditions, which affect our nervous system. Or if we could apply a little extra heat to the liquid nervous system it might stimulate the liquid crystal myelin into behaving as it should under normal circumstances.
In essence this is exactly what I believe has been happening to people on the Gravity Study. Everyone at some point noticed an increase in circulation and metabolism, which of course means additional warmth. In fact, many people, whom I have already helped, noticed that they are producing less urine during the night, indicated by fewer bathroom visits. This is due to the fact that the skin surface temperature has remained stable during the night rather than falling, as would be expected during horizontal bed rest.
With the additional warmth more water is lost from the lungs and skin, and a higher specific gravity occurs in the remaining liquids. This in turn increases circulation and metabolism, producing additional warmth, which as I have stated has implications for the liquefaction of the damaged myelin. This did not come as a surprise to me. My discovery, which led to this exciting new understanding of the influence of gravity in the bulk circulation of fluids and of every single cell in the human body.
Three people on my pilot study who suffered from thrombo -embolism's, found that the hard lumps which were evident in their legs disappeared. One lady was concerned enough to ask her GP if it could have moved to another part of her body.
Thrombosis improved because circulation was restored to the affected area and the blockage was gently dissolved away. Although this is not MS related I feel it is relevant to the re-liquefaction of damaged myelin.
Gravity has indeed been shown to be a very important factor in driving fluids throughout the nervous system. However if gravity is allowed to run in the wrong direction through the body for prolonged periods, then these same forces, which maintain our vital functions, wreak havoc by flowing through vital soluble tissue in the brain and nervous systems.
When the body is resting flat on a conventional horizontal bed, evaporation from skin and lungs etc concentrates the liquids, which remain in the body. These concentrated solutions find the most direct route down to the ground and this usually means flowing through brain tissue and or the nerve tissue and any other vital soluble organs or vessels.
When this occurs in the brain it would cause lateral lesions in the form of micro tubular scar tissue. The reason that lesions are found in this form is that sedimentary deposits form an outer membrane around the circulation and this is exactly how I believe all the tubes in the body of every living organism from a giant tree to an ant are formed. When applying this simple logic to the human body it becomes obvious why almost all of the bodies tissue and structure runs in tubular form from head to toe! Gravity must have played an important part in the formation of this tissue. When one considers that everything we are, developed from a tiny drop of fluid, it becomes enlightening to conclude that circulation obviously must have taken place before the surrounding cell tissue developed in the first place.
Gravity is stronger nearer the North and South Poles. This is because the Earth rotates and therefore the Equator, which spins with greater force, counteracts the pull of gravity, producing a significantly reduced level of gravity, due to the centrifugal force, caused by the rotation of the Earth. For example a wet spinning ball will throw water from the centre of the ball and not the top because the surface at the centre of the ball is spinning with greater force.
Around the Equatorial regions, the gravitational pull on concentrated fluids is significantly reduced by the above mentioned influences. This again relates particularly to horizontal bed rest, because here the damaging affects of fluids travelling in the wrong direction through vital soluble tissue as discussed previously would be influenced less by gravity at the Equator than at the poles. However, in arid areas evaporation would increase and therefore the production of heavy solutions would also increase respectively and possibly producing a different set of symptomatic problems.
For instance it is known that leprosy is found around tropical Equatorial regions and Leprosy is known to affect the nervous system. A detailed study of climate in the following study areas is required to establish a possible humidity or damp connection with increased levels of MS and other conditions.
Recent studies in the USA back up research findings in the UK and in countries in the Southern Hemisphere, showing that people living nearer to the Equator are at lower risk of developing MS. Viruses, Genetics and Race are thought to be partly to blame. Studies on migration have shown that people who move from an area of statistically high prevalence of MS to an area of low prevalence of MS reduce the chance of them developing MS, but only if they move before adolescence.
It is also thought that soldiers may have carried an infectious agent that may have been responsible for triggering MS in Soldiers during the Second World War, who inhabited both Iceland and the Faeroe Islands. Following that, there was claimed to be an increase in the incidence of MS. MS sometimes appears in 'clusters.' This means that MS cases are found in sufficient numbers and concentrations for it to be unlikely to have happened by chance. Most MS clusters turn out to be the results of accidents of time and geography, though a few have still not been adequately explained.
MS and Location. MS Matters Insight Supplement, issue 16, Nov/Dec 1997, Published by the MS Society.

The largest single difference between equatorial regions and the rest of the world is of course the climate. A warm, dry atmosphere above sea level, according to my theory is the perfect place to reside if you have MS, and would therefore bring about the opposite effects of those found in the river valley areas of the equatorial regions. Here it would be very hot and humid, and I suspect that a close statistical analysis of these areas would reveal clusters of people with MS or related problems.
On the other hand, if we keep gravity running through the body in the correct direction twenty-four hours a day for as long as it takes, regeneration of a damaged nervous system is possible irrespective of the severity of the condition. In fact, even complete spinal cord injuries have responded, and those involved in my trial continue to regain functions of the body, which a couple of years ago were thought to be beyond repair.
Restoration of the damaged optic nerve in multiple sclerosis has responded well to this treatment. So well in fact that several people have regained their sight, and in one case a lady who had lost the sight in one eye, through supposedly irreversible optic nerve damage, has been told that she may now legally drive a car without spectacles! Reference to eyesight improvements in MS and non-MS conditions are documented in the report from the MSRC, titled "Raised Bed Survey".

Humidity

Another consideration, which has been shown to have an affect on multiple sclerosis, is humidity. River valley areas in France (Rhone Valley Study) have been found to contain high levels of MS cases compared to the more elevated areas. A wrap around hair dryer, standing over a steaming cooker, a hot shower or bath have all been shown to increase the severity of MS symptoms, and sometimes trigger MS attacks. Higher air water content of course inhibits our ability to shed water from the skin and lungs which we discussed earlier. Moisture loss reduction from our lungs and skin slows down the circulation of fluids caused by the lack of development in retained concentrated fluids. In fact the clammy wet skin found under such environmental conditions should be self-evident and furthermore when fluids are present on the skin surface, so are salts. Sweat is produced when the body is placed under extreme conditions and the presence of vital minerals is an indication of just that.
Presse Med 1987 Apr 11;16(13):622-623 South-Eastern France, a high risk area for multiple sclerosis? [Article in French] Confavreux C, Darchy P, Alperovitch A, Aimard G, Devic M
A questionnaire-based prevalence study was conducted in the Chalon-sur-Saone and Avignon areas, in the Rhone-Saone valley, France, to determine the frequency of multiple sclerosis. These areas are 300 km apart and lie on the 47 degrees and 44 degrees North parallels respectively. Age-adjusted prevalence rates on March 20, 1984 were 58.5 and 48.6 per 100,000 inhabitants respectively. There was no significant difference between the two areas. These preliminary data suggest that southeastern France, as represented by Avignon, may fall within the high-risk area for multiple sclerosis.

SEASONAL VARIATIONS IN MS

People with MS and other neurological problems are able to forecast rain!
This is not however related directly to their MS. Cattle for instance are observed to lie down prior to a down pour. It has been suggested that they do so to reserve a dry area of land. Somehow I doubt that this is the case.
Cattle and other animals lie down because the increase in humidity prior to rainfall slows down their circulation and metabolism, making them lethargic, so they lie down. if a hillside is in close proximity cattle and sheep will all be laying down on the hillside and facing uphill!
MD's ONLINE from AOL - This material is quoted and provided as general medical information.
Question
Do you think that seasonal allergies could play a role in explaining these variations in the pattern of relapses? Have studies been done on the correlation between pollen levels, sensitivity to allergens and relapses? One logic for a connection might be that allergic attacks might affect the permeability of the blood-brain-barrier.
Answer
The reason for seasonal variations in the pattern of relapses in multiple sclerosis is unknown. Attempts have been made to correlate it with the incidence of viral and other infections, but there is no clear-cut pattern there. I don't know of any evidence to suggest that it be related to seasonal allergies. Perhaps there is a cyclic alteration in the reactivity of the immune system at various times of the year, but this is only conjecture on my part, and I don't know of any studies that would confirm or strongly support it.
Question
Why is it that many MS attacks come in the Spring or Fall when the weather changes? I've heard that more viruses are common during these times causing attacks, and that allergies cause the attacks. Can it also simply be a metabolic reaction by our immune system adjusting to the new season?
Answer
You are correct that there is evidence that relapses in multiple sclerosis have seasonal variations. Not all the studies performed are consistent but there does appear to be varying patterns depending on the locality where the studies are done. In a very carefully performed study in North Dakota, for example, September was a very high month for relapses but not the spring months. On the other hand, the summer months did appear to have increased incident of relapses as well. In other studies, exacerbation's have increased in the spring as well as in the fall, as you suggest. The implication here is, as you suggest, that something important in the environment is playing a role. It is known that certain types of viral infections can predispose to relapses and its possible that this could be the environmental relationship. On the other hand, when it is carefully looked for such as in the North Dakota study, it did not correlate with the incidents of various types of infections. There are of course, other variables that could play a role including temperature as well as light conditions.
Your question has also prompted me to review the more recent as well as past literature on the topic. While it does appear that an answer to this phenomenon could be important, I was struck by the fact that the number of published papers on the subject have greatly decreased in the last years. I do believe it's likely that once the full story of MS is unravelled, that the seasonal variations will be explainable. In some instances, I have seen patients who have the exacerbation's, yearly around the same time, for more than three years. While these are very isolated events, and conclusions cannot be drawn from them, it would suggest however, that there may be individuals who are more prone to seasonal changes than others perhaps.
International MS Support Foundation, P.O. Box 90154, Tucson, Arizona 85752-0154
Pauline, from Devon, mentioned in the Snooze Report, found that initially, when she introduced a dehumidifier during the night in conjunction with the new sleeping position, which she had been using for many months, her dropped foot problem would disappear. However when she discontinued the use of the dehumidifier her dropped foot problem would re-emerge. She repeated this procedure several times in order to make sure that it was the dehumidifier, which restored the function in her foot. This alone should be evidence that evaporation and gravity are two very important considerations in relation to the circulation of fluids within the nervous system.

Dr Nieper: Towards the end of 1984, I had an MS patient from the vicinity of Eureka in Northern California. Her husband reported that they lived in a region of continual earthquake activity and not far from a place where a man must stand at an angle and not perpendicular to the earth, to keep from falling down. In that region, the frequency of MS is over 4,000 per million. This would be more than ten times higher than in an average cross section of the country.
This interesting observation indicates that where the Earth's gravitational field is compromised in what is now known as a Geopathogenic Zone the percentage incidence of multiple sclerosis rises way above a national average.
Dr. Hans A. Nieper: The Treatment Of Multiple Sclerosis Sept. 1985


SPACE TRAVEL

In space travel, where gravity is also compromised, astronauts who are normally selected for their physical fitness suffer considerable damage to their nervous system. The severity of damage depends on the length of time they spend in micro gravity conditions. Once exposed to normal gravity conditions on return they encounter considerable difficulties in walking, amongst other normal bodily functions.
In order to induce the harmful effects of micro gravity, both NASA and Russian scientists have found a significantly cheaper method. They use prolonged bed rest to induce many of the harmful side effects to perfectly healthy would-be astronauts. I remember seeing a documentary about these experiments on TV some time ago. During this program cosmonauts suffered many damaging side effects and some to the point where they are no longer able to walk.



DEEP SLEEP

Take a group of people without any neurological problems, other than depression and confine them to bed for several months, without allowing them to get out even for bathroom visits. Medicate them so that they don't feel too uncomfortable.
Result: People die, lose their ability to walk, renal function packs up, they get osteoporosis, Some of them develop severe mental disorders, leg ulcers, gangrene, skin conditions, paralysis, atherosclerosis heart conditions, arthritis and many of the survivors eventually commit suicide. All of this actually happened in Australia during the now infamous "Deep Sleep" therapy programme. "Probably on the net somewhere".

So if  it is possible to induce all of these horrific medical conditions by depriving people of exercise and vertical posture, a conclusion surely is that incorrect posture could also induce MS related symptoms.

Keyboard Syndrome

Sitting at the computer keyboard for hours on end brings with it for some of us a few circulatory problems, tingling in hands and fingers, numbness, finger cramp, paralysis and icy cold fingers. The problem appears to remain for a few days. In my own experience, to eliminate this problem I have found that if I raise my seat up so that my hands and arms slope down to the keyboard rather than up or horizontal to the keyboard, the problems of numbness and tingling for me at least do not occur .
The reason that these irritating problems happen is due to incorrect posture, in which gravity is unable to influence the circulation of fluids within the circulatory and nervous systems. If this postural problem is not corrected it could well lead to progressive neurological degeneration.

Diet

Water leaves the body as discussed, but can only do so safely if the balance of supply matches demand. Providing the stomach contents are less concentrated than the downward flowing liquids caused by evaporation, circulation is able to continue. Therefore a dietary change from a lightweight (low in mineral) diet to a heavy diet could cause the circulation to be compromised. An early indication of a stomach imbalance is diarrhoea. Fluids in the stomach become too heavy to be lifted and pass through the bowels instead of the blood. In fact many laxatives are salt based. Dehydration follows and has been shown to respond to the addition of a small amount of salt and sugar dissolved in water and drank.
Dairy products as we know contain high levels of calcium and a huge array of minerals and fats producing a very high specific gravity within the stomach of the consumer. To demonstrate fill a tall glass to the brim with water. Carefully lower a small amount of milk contained in a teaspoon so that it rests with its edges at the surface of the water. Introduce it gradually to the surface of the water by tilting the spoon. Result: the milk rapidly falls to the bottom of the glass, indicating that it is a heavy mineral laden liquid. Therefore dairy products like cheese and butter, which are concentrated further, would alter the specific gravity of the stomach.
Furthermore the addition of sugar and cocoa in chocolate sweets and cakes would serve to add further weight to the liquids contained in the stomach. On the North side of the Rio Grande, in Texas, it is found that the frequency of MS is at least 10 times higher than on the other side in Mexico. In Texas, the usual diet is Anglo-American, with a heavy emphasis on dairy products. In Mexico, the usual fare is of the Spanish-Mediterranean Milk poor diet. (Olive oil instead of butter).
In South Africa, MS is concentrated in the province of Natal, even though they have plenty of sunlight there. Here again, this is the dairy region. In Australia there seems to be a decided difference in the frequency of MS in different provinces. Here again the pattern fits; it is one of milk production and dairy product consumption.

My work with people with MS indicates undeniably that it responds to the omission of horizontal bed rest and poor sitting posture!

This surely then leads to the conclusion that MS in all probability is caused by progressively longer periods of horizontal bed rest or prolonged bed rest, possibly resulting from an accident or an illness, or as well as poor prolonged sitting posture, in an otherwise susceptible person. High humidity levels also influence the activity of a person and therefore must contribute to the general condition of people living in such conditions.
A questionnaire asking people if they had moved to a low lying coastal or river valley area or even residing in a damp home prior to contracting their illness would reveal some startling data. Another question relating to prolonged bed rest due to an accident or illness prior to first symptoms of MS would, I am sure, produce even more enlightening data. Further more if questioned about their improvements when they occur while in the relapsing remitting stages, I am sure it would be found that a high percentage of people would relate to a dryer time of the year or a holiday abroad, etc. (See MS and Weather)
 
------Ongoing  unpaid research------

Andrew Fletcher © December 1997 , Summer Haze, 26 Berry Drive, Paignton, Devon, TQ3 3QW, UK
If you have access to the Internet and would like to join our study, send an email to this address
Telephone or FAX 01803 524117   International : 44 1803 524117


"The explanation requiring the fewest assumptions is most likely to be correct."
K.I.S. "Keep it simple!"


 

Offline neilep

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #1 on: 27/03/2006 01:38:43 »
Andrew..are you ok about providing such precise contact info ? ie: your home address and telephone number  ?

I might start ordering you pizzas  !!
 

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #2 on: 27/03/2006 18:25:32 »
Hi Andrew,
The orthodox view is that Multiple Sclerosis is an autoimmune disease.

" MS is a type of autoimmune disease in which the body mistakenly recognises myelin as 'foreign' and attacks it. This causes the wide variety of symptoms associated with MS and leads to inflammation and nerve fibre loss. "
http://www.mssociety.org.uk/research/research_we_fund/grant_651.html

This is view is supported by MS's association with autoimmune diseases:-
http://www.webmd.com/content/article/111/109882
« Last Edit: 27/03/2006 18:31:47 by ROBERT »
 

Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #3 on: 28/03/2006 08:53:18 »
Hi Robert, I am fully aware of the current thinking on Multiple Sclerosis and many other neurological conditions.

The new theory is based upon evidence collected while conducting several pilot studies, which involved tilting a bed. I am also fully aware of how uncooperative the M.S. Society and the Multiple Sclerosis Resource Centre can be, when faced with compelling evidence.
There are two ways this can be argued. One is to argue on the basis that someone else has written something different so this can't be correct.

The other is to investigate the claims in the new theory, get a few people with multiple sclerosis to sleep on an incline for a year or more and analyse the results, or better still get the Multiple Sclerosis Resource Centre to Analyse the results in an impartial way and compile an independent report. Then ask a few more people with multiple sclerosis to repeat the pilot study and see if the results can be replicated.

And when you have done this, you are still left with the Health Industry pointing out that all of your results so far could be mass spontaneous remission. So you set up another pilot study involving 3 people with complete spinal cord injuries to sleep on an inclined bed on the off chance that they will also recover function, bowel and bladder control and sensation below the injury point. Even to the point that one of them walks on Carlton Television News after almost 11 years of Paralysis. Then finding that the results could still be ignored under the pretext of this could have happened anyway, you set up a larger study with people who have sustained a spinal cord injury and again begin to see the evidence replicated by people you have not even met in person on the other side of the world.

Which is where I am at present with this theory.


Andrew


"The explanation requiring the fewest assumptions is most likely to be correct."
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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #4 on: 28/03/2006 10:26:07 »
It is possible you are onto something with your bed inclination stuff Andrew (do you put head up or down) however your theories about why this is the case are dodgy. Make sure when presenting this idea you just present the data and not the theories behind it, you will be a lot more likely to be taken seriously. If you want help presenting the data I would be happy to do so.
 

Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #5 on: 28/03/2006 20:15:21 »
Dave, I know exactly what I have nailed here, and take on board your offer of help compiling and presenting the data, and thank you for your kind offer of help, which I may well rely on in the near future.

The theory has been the driving force behind tilting the bed in the first place, and the events I have witnessed helping people with it are unprecedented in the annals of medicine, yet fly in the face of physiology as it is understood and written in the text books.

The only thing wrong with my theory is that it was discovered by someone unimportant.



"The explanation requiring the fewest assumptions is most likely to be correct."
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Offline daveshorts

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #6 on: 28/03/2006 22:56:10 »
There have been many people who have come up with the right answer for the wrong reasons and vice versa - look a Newton with the corpuscular nature of light, or Maxwell with his little cogs in space, so don't think of it as an insult.

The way that science should happen is that you present your data and possibly a theory, people try and test both, and what survives survives. At the moment there a a lot of very good evedence to show that liquids move around the body by being pumped with the blood, osmosis and various active transport mechanisms. Gravity does play a role but it is very minor.

There are however lots of other reasons why sleeping at an angle could make people healthier, such as if they had difficulty breathing when asleep it may help to open the airway etc.

I would strongly advise just presenting your data, and if the scientific community can't come up with a better explanation then possibly introduce your theory. That way at least you may be able to help a lot more people.
 

ROBERT

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #7 on: 07/04/2006 15:44:16 »
Anyone researching therapies for MS should be aware that MS can follow a "relapsing-remitting" pattern. During remission there is a marked recovery, e.g. sufferers can regain the vision they have lost, and the ability to walk. This recovery is due to remyelination which occurs naturally.

If a therapy was used during this remission period it would be possible to wrongly attribute the recovery to the therapy , when in fact it was naturally occuring, and the therapy useless or even harmful.

" CLINICAL COURSE
There are four clinical courses of MS, with the potential for an individual to progress from a less
serious to a more serious course over time:
1. Relapsing-remitting MS: Persons classified as having relapsing-remitting MS experience
clearly defined relapses—episodes of acute worsening of neurologic function—followed
by periods of remission without disease progression. In some cases, people experience a
residual deficit following an attack.
2. Secondary progressive MS: People with secondary progressive MS experience a relapsingremitting
disease course at onset, followed by progression with or without occasional
relapses, minor remissions, and plateaus. Although the disease usually begins with
a relapsing-remitting course, most individuals eventually transition to a progressive
disease course.
3. Progressive-relapsing MS: Persons with progressive-relapsing MS experience progressive
disease from onset, with clear, acute relapses that may or may not resolve with full
recovery. Unlike relapsing-remitting MS, the periods between relapses are characterized
by continuing disease progression.
4. Primary progressive MS: People with primary progressive MS experience a nearly continuous
worsening of disease that, by definition, is not interrupted by distinct relapses.
Some of these individuals do have occasional plateaus and temporary minor improvements.

Health professionals tend to have greater exposure to individuals with the more serious forms
of the disease. Therefore, it is important to note that the majority of individuals with MS do not become severely disabled
."
www.nationalmssociety.org/pdf/forpros/BasicFacts.pdf
« Last Edit: 07/04/2006 15:48:27 by ROBERT »
 

Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #8 on: 08/04/2006 00:26:07 »
The Two ladies that regained their sight were not relapsing remitting stage M.S., any more than the others were in the pilot study. In fact they had supposedly irreversible optic nerve damage caused though long term progressive multiple sclerosis! Many of the people that recovered a huge amount of function and sensation, were in fact diagnosed with long term progressive M.S. And were therefore ineligible for the ABC drug trials.
Just for the record Rob :)

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Offline hawaiigirl413

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #9 on: 11/04/2006 02:51:26 »
Dear Andrew,  I am using the incline sleeping position now for about 3 weeks.  I do really like it.  I was diagnosed with MS 10 years ago after having mercury fillings improperly removed from my teeth.  I also was poisoned with dental plastics.  I did chelation for lead, aluminum and arsnic.  I has also chemically sensitive and was auto immune problems with (lupus?)  Parasites, yeast, leakygut.  Allergic to many foods esp sugars and fats.  I have read your theory on ms and have noticed increased autoimmune response when using milk products.  Knuckles swell, much aches and pains.  I am questioning the link of ms with heavy metal poisoning and neurotoxins. (MSG and Aspartane) etc.  I have severe reactions to both of those ingredients.  How does toxins in the fat relate to MS?  I understand the water and fat transmission of energy and the melting point of fat. etc.
 

Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #10 on: 11/04/2006 14:21:26 »
HI

Glad to help you with the inclined bed. There is going to be some initial pains and aches, this is because the nervous system is receiving one huge stimulus from gravity and unfortunately there is going to be some discomfort when the nerves begin to fire up again. This usually resolves within a few more weeks. Each time a new gain is observed it is very often observed following a period of unusual pains, explained as shooting pains.

The knuckles swelling may be a result of an initial shift of tissue fluids down to the hands due to the incline, again this should resolve quickly.

Get hold of a dehumidifier and use it in the bedroom with the bed inclined, this hugely accelerates the recovery!

Andrew

P.S. I have a skype phone

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K.I.S. "Keep it simple!"
« Last Edit: 11/04/2006 20:37:08 by Andrew K Fletcher »
 

Offline Bass

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #11 on: 13/04/2006 04:54:50 »
Andrew
I recently read (somewhere?) that there is a statistically higher incidence of MS for individuals that had mononucleosis in their youth.  The paper did not suggest that the epstein-barr virus was to blame for the development of MS, but rather that it somehow altered the immune system.  Have you seen any research on this- if so, do you have any comments?
Several acquaintances of mine either have MS or have family members with MS- so I find this whole thread fascinating.


Subduction causes orogeny.
 

Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #12 on: 13/04/2006 10:10:12 »
Hi Bass

Virus is more prevalent in river valley areas and Coastal regions. 2 studies in France, one in the Rhone River Valley revealed a 46% increase above National average. Also, Leslie Munroe, (Found in Open University National Statistics) revealed that Sudden Infant Death Syndrome is also 46% higher in the same areas. It comes as no surprise to me that there is a connection between viral infection and the onset of M.S. Possibly Further exacerbated by prolonged periods of bed rest following the infection. There is also a correlation between injury and the onset of M.S. During my research into multiple sclerosis, I sent out a questionnaire asking people what was their worst time of day, where they lived and if they had recently moved prior to the onset of a relapse or recovery, the reports I got back proved a firm link between living in damp climates, working in humid environments, or sustained injury or illness prior to onset of M.S.

I took this scenario further performing an investigation into weather patterns prior to foot and mouth outbreaks in the U.K. and found prolonged unusually wet weather prior to both of the major outbreaks in the U.K. Also got a mention in the Devon Foot and Mouth Enquiry, but as per usual has been dutifully ignored.



"The explanation requiring the fewest assumptions is most likely to be correct."
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Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #13 on: 13/04/2006 10:19:28 »
http://groups.google.co.uk/group/inclined_to_sleep_inclined

The above link takes you to some of the anecdotal data collected on a study which closed when the provider of the message board closed the sites. Even so there are some significant reports from people that simply tilted their beds.



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Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #14 on: 13/04/2006 10:34:10 »
http://tinyurl.com/afsl8

The above link relates to the inclined bed, and on this page there is a pdf file, download the file and scroll to the bottom to find the Multiple Sclerosis Resource Centre Independent Report, relating to the first pilot project with people how have M.S.

"The explanation requiring the fewest assumptions is most likely to be correct."
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ROBERT

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #15 on: 13/04/2006 16:24:52 »
quote:
Originally posted by hawaiigirl413

 I was diagnosed with MS 10 years ago... auto immune problems with (lupus?)


Hi Hawaiigirl413,
There is a condition called "Lupoid Sclerosis" where a person has Lupus which includes Multiple Sclerosis.
 However people with Lupus can have neurological disorders which resemble MS such as "Cerebral Vasculitis" and "Antiphospholipid antibody Syndrome (APS)", also known as "Hughes Syndrome".

It is very important to ensure which neurological disorder you have as different treatments could be applied,
 e.g. Hughes Syndrome (APS) is readily treatable with inexpensive anti-coagulant treatment.
------------

"  Hughes Syndrome
Could you have been misdiagnosed with multiple sclerosis?
 
 Apparently, Hughes Syndrome can easily be mistaken for Multiple Sclerosis. It shares many of the symptoms and as many as 1 in 3 people diagnosed with MS actually have Hughes Syndrome.

Hughes Syndrome is also known as Sticky Blood Syndrome although it's proper title is Antiphospholipid Syndrome (or APS). Discovered by a Dr. Graham Hughes in 1983 while treating patients for the Lupus condition. Sticky Blood can be easily treated with Aspirin, Heparin or Warfarin but, if left untreated it can be fatal. Sticky blood can lead to the formation of blood clots which can cause Thrombosis or Strokes.

The symptoms of Hughes Syndrome can be uncannily like those of MS. They may include: difficulty with walking, foot drop, double-vision, tingling sensations, slurred speech and loss of balance. I don't know about you, but this is ringing some fairly loud alarm bells with me. Like MS, Hughes Syndrome is an autoimmune deficiency and it's cause is unknown.

Read the MS Resource Centre's article or visit the Hughes Syndrome Foundation Website.

My thanks to the Lady from Port Macquarie in New South Wales for bringing this item to my attention. She would like to see all possible MS diagnosis patients automatically tested for Hughes Syndrome. I promised I would include a piece on the subject and here it is, admittedly short and sweet, but here all the same. "
http://www.mymultiplesclerosis.co.uk/hughes-syndrome.html
 
« Last Edit: 13/04/2006 18:08:31 by ROBERT »
 

Offline sdurkee34

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #16 on: 20/04/2006 00:56:48 »
has anyone heard that the darker your skin the color the more myelin you have on your axons thus creating quicker reactions from the central nervous system, which allows better explosive movement such as jumping by people of color?  My old coach who has his phd in excercise science said that one of his grad school professors had said this but i have been unable to find any written sources of this?

steve durkee
 

ROBERT

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #17 on: 20/04/2006 16:21:23 »
quote:
Originally posted by sdurkee34

has anyone heard that the darker your skin the color the more myelin you have on your axons thus creating quicker reactions from the central nervous system, which allows better explosive movement such as jumping by people of color?  My old coach who has his phd in excercise science said that one of his grad school professors had said this but i have been unable to find any written sources of this?

steve durkee



Hi Steve,
you may be confusing myelin with melanin.

"melanin : a substance that gives the skin its color (also called pigment).
melanocytes : cells present in the epidermis that produce melanin (skin pigment)."
http://www.luhs.org/health/topics/skin/glossary.htm

"Myelin: The fatty substance that covers and protects nerves. Myelin is a layered tissue that sheathes the axons (nerve fibers). This sheath around the axon acts like a conduit in an electrical system, ensuring that messages sent by axons are not lost en route. It allows efficient conduction of action potentials down the axon. Myelin consists of 70% lipids (cholesterol and phospholipid) and 30% proteins. It is produced by oligodendrocytes in the central nervous system. "
http://www.medterms.com/script/main/art.asp?articlekey=4477



 

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #18 on: 26/04/2006 15:47:59 »
quote:
Originally posted by ROBERT

Anyone researching therapies for MS should be aware that MS can follow a "relapsing-remitting" pattern. During remission there is a marked recovery, e.g. sufferers can regain the vision they have lost, and the ability to walk. This recovery is due to remyelination which occurs naturally.
If a therapy was used during this remission period it would be possible to wrongly attribute the recovery to the therapy , when in fact it was naturally occuring, and the therapy useless or even harmful.



Here is some evidence to support my statement above:-

" Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier.
summary: This paper shows that demyelination can be repaired by remyelination in both humans and rodents, and even within the central nervous system remyelination can be achieved by endogenous and/or exogenous Schwann cells, the myelinating cells of the peripheral nervous system.

Authors: Black JA, Waxman SG, Smith KJ

source: Brain. 2006 May;129(Pt 5):1319-1329. Epub 2006 Mar 14."
http://www.msif.org/en/research/research_news/dorsal_column.html

 
 
« Last Edit: 26/04/2006 15:56:03 by ROBERT »
 

Offline Andrew K Fletcher

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #19 on: 27/04/2006 07:40:28 »
Hi Robert

Would you be trying to imply that these results were a fluke and would have happened anyway?

Andrew

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #20 on: 22/05/2006 11:15:09 »
quote:
Originally posted by Bass

Andrew
I recently read (somewhere?) that there is a statistically higher incidence of MS for individuals that had mononucleosis in their youth.  The paper did not suggest that the epstein-barr virus was to blame for the development of MS, but rather that it somehow altered the immune system.  Have you seen any research on this- if so, do you have any comments?
Several acquaintances of mine either have MS or have family members with MS- so I find this whole thread fascinating.




" Epstein-Barr Virus and Multiple Sclerosis
Evidence of Association From a Prospective Study With Long-term Follow-up

Gerald N. DeLorenze, PhD; Kassandra L. Munger, MSc; Evelyn T. Lennette, PhD; Norman Orentreich, MD; Joseph H. Vogelman, DEE; Alberto Ascherio, MD, DrPH


Arch Neurol. 2006;63:(doi:10.1001/archneur.63.6.noc50328).

ABSTRACT  

Objective  To determine whether serum titers of anti–Epstein-Barr virus (EBV) antibodies are elevated in blood specimens collected up to 30 years prior to onset of multiple sclerosis (MS).

Methods  Individuals with MS were identified among members of the Kaiser Permanente Northern California health plan who participated in the multiphasic examinations administered between 1965 and 1974. Stored serum samples were used to compare anti-EBV antibody titers in 42 individuals who developed MS with age-matched and sex-matched controls.

Results  The geometric mean titers of antibodies to the Epstein-Barr nuclear antigen (EBNA) complex and its component EBNA-1 were significantly higher in the MS cases when compared with matched controls. The relative risk of MS associated with a 4-fold increase in antibody titers was 2.1 (95% confidence interval, 1.1-3.8) for the EBNA complex and 1.8 (95% confidence interval, 1.1-2.9) for EBNA-1. Elevations of antibody titers to the EBNA complex and EBNA-1 among MS cases first occurred between 15 to 20 years before the onset of symptoms and persisted thereafter.

Conclusion  The elevation of anti-EBV titers is probably an early event in the pathogenesis of MS and is unlikely to be the result of an aspecific immune dysregulation.

Published online April 10, 2006. "
http://archneur.ama-assn.org/cgi/content/full/63.6.noc50328

So their suggestion is that Epstein-Barr is a "viral trigger" for the development of MS.
« Last Edit: 22/05/2006 11:16:54 by ROBERT »
 

ROBERT

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Re: NEW MULTIPLE SCLEROSIS THEORY
« Reply #21 on: 09/08/2006 15:52:39 »
quote:
Originally posted by iko

The old cod liver oil could help restoring immune balance, but it  would probably take some time (several months).
I wasn't able to find clinical results about vitamin A,D and omega-3 (the main components of cod liver oil)in MS...but I'll go on surfing PubMed!



MS is autoimmune inflammation.
Cod liver oil does have mild anti-inflammatory properties:
IIRC one cod liver oil capsule is only equivalent to about 1/4 of a standard (200mg) Ibuprofen tablet.
The fats in Cod liver oil may assist remyelination in people with MS, (myelin is mostly fat).
« Last Edit: 09/08/2006 16:20:16 by ROBERT »
 

Offline that mad man

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NEW MULTIPLE SCLEROSIS THEORY
« Reply #22 on: 29/07/2007 16:29:52 »
A recent study by a team from the University of Southern California is suggesting that UV rays from the Sun may boost the vit D levels.

This may alter the cells immune response making it up to 40% of a lesser chance at developing MS.

That is from the latest research published in the journal Neurology and that I have been reading a bit about on the BBC web site only today.

Quote:
"The implication here is, as you suggest, that something important in the environment is playing a role."

Maybe its vitamin D!


Perhaps that is why at either end of the summer, lesser UV months, there is a greater incidence of relapses


 

Offline Andrew K Fletcher

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NEW MULTIPLE SCLEROSIS THEORY
« Reply #23 on: 01/08/2007 06:46:31 »
Or maybe when the sun goes in, it's generally damp or raining and in river valley areas or low lying coastal areas where the mist hangs often well into the day the humidity in these areas is 90% compared to 50% which is a healthy environment. Think they are barking up the wrong tree as per usual.

Andrew
 

Offline Andrew K Fletcher

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NEW MULTIPLE SCLEROSIS THEORY
« Reply #24 on: 19/01/2009 10:12:12 »
http://jnnp.bmj.com/cgi/rapidpdf/jnnp.2008.157164v1.pdf
Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
Paolo Zamboni 1*, Roberto Galeotti 1, Erica Menegatti 1, Anna M Malagoni 1, Giovanna Tacconi 1, Sergio Dall'ara 1, Ilaria Bartolomei 2 and Fabrizio Salvi 2

1 Vascular Diseases Center, University of Ferrara, Italy
2 Neurology, Bellaria Hospital, Bologna, Italy

Accepted 10 November 2008


*     Abstract

Background: The extracranial venous outflow routes in clinically defined multiple sclerosis (CDMS) have never been investigated.

Methods: Sixty-five patients affected by CDMS, and 235 controls composed, respectively, of healthy subjects, healthy subjects older than CDMS patients, patients affected by other neurological diseases, and older controls not affected by neurological diseases but scheduled for venography (HAV-C), blindly underwent a combined transcranial and extracranial Color-Doppler high-resolution examination (TCCS-ECD) aimed at detecting at least two of five parameters of anomalous venous outflow. According to the TCCS-ECD screening, patients and HAV-C further underwent selective venography of the azygous and jugular venous system with venous pressure measurement.

Results: CDMS and TCCS-ECD venous outflow anomalies were dramatically associated (OR 43, 95% CI 29-65, p<0.0001). Subsequently, venography demonstrated in CDMS, and not in controls, the presence of multiple severe extracranial stenosis, affecting the principal cerebrospinal venous segments; it configures a picture of chronic cerebrospinal venous insufficiency (CCSVI) with four different patterns of distribution of stenosis and substitute circle. Moreover, relapsing-remitting and secondary progressive courses were associated to CCSVI patterns significantly different from those of primary progressive (p<0.0001). Finally, the pressure gradient measured across the venous stenosies was slightly but significantly higher.

Conclusion: CDMS is strongly associated with CCSVI, a picture never been described so far, characterized by abnormal venous haemodynamics determined by extracranial multiple venous strictures of unknown origin. The location of venous obstructions plays a key role in determining the clinical course of the disease.

This paper is very exciting for myself and people with multiple sclerosis.

http://answers.google.com/answers/threadview/id/271074.html here is another doctor who is convinced that MS is caused or at least contributed to by fluctuations in venous pressure. Franz Alfons Schelling, MD

 

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