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New Theories / Re: Post Orgasmic Illness Syndrome (POIS)
« on: 30/11/2009 03:26:37 »
has any body tried low dose , i am getting a prescription tomorrow. it appears to be a wonder drug for many different aliments.
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i think he might be right about the fmri,if normal people have varying results, we might not have anything concrete to interpret the data with. i personally think that my brain would look normal durning o anyways. somthing like taking a math test(on fmri or mri) before o, and after while in pois, would tell us a great deal about what areas are affected by cognitive dysfuntion. narrowing down what areas are effected by decreased brain activity is the first step in the right direction. another step in the right direction would be to match a pois patient test agian the data from that study(prolactin/dopamine) where the people were hook up to a machine that automatical draws blood at givin intervals before, during, and after orgasm. in this case we would have solid data from that study that we could match our nuero/endocrine chemicals toward.An open post to hurray, EDS, and Defsync
The three of you magnanimously pledged some financial support to studying POIS. Many thanks again, that was an incredibly wonderful gesture on your part!
By pledging, you have done enormous good to the cause of curing POIS, giving us all renewed hope and confidence that we're on the right track.
Just wondering lately, since the outside world of research is slow in rushing to our aid (we've been at this forum for 3 years now), how would you three feel about starting "somewhere". Anywhere. But Now! Using our own considerable resources?
A few of us here think that a state-of-the-art SCAN of the brain, such as an fMRI, before, during and after orgasm, could reveal plenty.
This advanced scanning (not generally available publicly) could give us deeper insight into the hormonal/neurotransmitter/brain-function data that we seem to be "just around the corner" from finding. I would be glad to be "team captain" with doctors, labs, etc., but not a good subject because of my testosterone/stimulant POIS treatment regimen.
I posted this here, publicly, because the more input (from you as well as everyone else here at the forum) the better!
What do you think?
Judging from what I've seen around the interwebs on fMRI's of brains during orgasm, I'm not sure how well a tool it would be for zeroing in on POIS related structures/causes. I say this because it seems there are very different results from fMRI's of different "normal" people's orgasms, and it appears that doctor's aren't exactly sure yet why that is yet. I may also be biased since my doctor ordered a $18,000 MRI and EKG for my POIS and it showed nothing abnormal. Granted an fMRI shows bloodflow and oxygen level changes within structures of the brain, without a fram of reference or a "what exactly are we looking for" I'm not sure how this might work. I guess if someone did have a pretty good reason, and they were insured, convince their doctor to obtain one of these through insurance just like some of us have with regular MRIs?
to get on Oprah we need to come up with some horror stories about our lives that read like a Greek tragedy, people love to hear about others who have worse problems then they do. pois sounds like the perfect subject for an Oprah/Dr. oz special.
I think it would be possible that maybe one of us could somehow get onto a talk-show such as Dr. Oz or something where they can help us figure out whats happening
ive emailed oprah and ellen a couple times already, with no such luck
any body ever take acutane?i just threw that acutane thing out there because i took it when i was young.
I think this has been asked before.... but the answer here is yes, lots of it for ACNE 26 years ago.
PS.
Has anybody checked for any kind of adrenal tumors, I think adrenaline just may be released too much after sex. All my POIS is now is a rush of adrenaline and energy or something that keeps me up at night, thats why i'm posting here at 6 in the morning
I do notice a rush of energy immediately afterwards, whereas the "normal" response for guys is to roll over and snooze. []
Yes, thats really weird. It's just the past 2 months where now if I orgasm I get a rush of energy, go temporarily manic, and than the crash a day aferward, but the POIS time has pretty much shortened in length, honestly lasting 3-4 days, sometimes 2 days after O instead of the 2 weeks it had taken me before.
Does anybody here have acne? I think that might have something to do with my POIS, since I also tend to really break out after O.
i have symptoms of adrenal fatigue/cognigitive dysfunction and insomnia all the time, out of pois just means my symptoms are better. i would still be sick even if i never o'd again, o'ing just makes my life even more unberable. it is possible that my pois is a secondary symptom from some type of chemical deficit. i think of my body/physiology as being a working deficit.
I put ".75cc im" of "T" into my system yesterday evening for test purposes. I usually test T after "O" once in a while, but I have not o'd in 10-12 days. I felt good today, cleaned my house, washed all dirty clothes, etc... but I can still feel the horible symptoms lurking just under the surface, that are just being masked by "T" not cured. The positive effects will start to diminish over the next day or two, but for now I will take advantage of extra energy.
If no sex activity for 10-12 days, why are POIS symptoms "lurking"? Do your POIS symptoms last 2 weeks?
I feel there's a cure with T for me and it's somehow associated with speeding up sperm re-generation. But I can't prove it yet. Strong hunch. But even if worst case were true, and T is only "masking" symptoms, I'll take it. It's a cure for me.
These days, I'm functioning as a human being like I never did in my whole life. I never dreamed this was possible. And it's been holding now for about one year!
Today, Day Zero, was not as good for me as the last 5-6 times. A strong nap (over an hour) was necessary for me this afternoon to re-stabilize.
demo, anything abnormal with pituitary gland
has anyone done ECG, EEG, CT, MRI, blood pressure, glycemia, blood count, temperature, hormones right after orgasm?
Exactly what needs to be done! I did MRI of the brain (pituitary) and some of the above, but a week after.
has anyone done ECG, EEG, CT, MRI, blood pressure, glycemia, blood count, temperature, hormones right after orgasm?midodrine looks interesting, but my doctor probably wont prescribe it to me since i just convinced him let me try various beta blockers a month ago. if a came back with in a months time with a hypotensive medication "midodrine" he would have me on a short leash. i still think that low brain oxygen is partly to blame for cognitive dysfunction.
also has anyone looked at midodrine ?
My POIS treatment
Lately, I've been able to maintain almost 100% POIS-free episodes (increased testosterone and increased adderall). Can't really explain it (the near-100%). Maybe the treatment is catching up and is in effect a "wholesale cure"!
Today, when Day Zero symptoms started creeping up, I forced myself out into the sunshine...and it worked! (My natural tendency on Day Zero is to maximize physical/mental passivity). Simplistic? You bet! []
Don't most Asians lack the enzyme to convert alcohol into a non-toxic substance "asian flush" interesting because my hangover is very similar to pois.... also i know it sounds weird but my pois has a little to do with circulation cuz standing on my head after orgasm takes the depersonalization away...i know it sounds weird but very easy to test out so if it works for anybody else please tell me so i don't feel crazy:)
Watson Pharmaceuticalsgood job demo your on the ball right now
We got a great reception today! []
The woman I spoke to demonstrated that by writing up our conversation and circulating it to several departments.
She went to our forum site here as we spoke. She asked to see Dr Waldinger's paper and I will send it tonight, along with other POIS links of interest. I said Waldinger's paper adds credibility when we show it to our physician and that a "Watson Study Of POIS" would help too, especially with endocrinologists.
No promises, but I do feel good about this one.
She also said I'm a great spokesman for POIS [] But personally, I think Johnny Depp would do better!
I was wondering if somebody could take Benadryl allergy and/or motrin to see if they have relief of at least some their symptoms. Something is helping me but I'm not sure what it is.motrin/ibprophen gives me some relief from intial symptoms during first cupple days, expecialy right after o. alieve/naproxen sodium gives me better relief.
I am taking vitamin B's, chelated magnesium, calcium magnesium, and motrin. Even rhodiola rosea. I've also been stretching my neck out and rotating it (not sure if that's really helping me or not).
But I would like if somebody has either motrin or benadryl allergy to take some and tell me how you feel, if you don't feel a difference it just cancels those out for me. I don't think it is the vitamins I'm taking, even though I really "felt" the good feeling of vitamin B after I haven't taken it in a long time. Thank you
This goes back to a theory about POIS that we've discussed - the better the "quality" of orgasm, the less severe the symptoms of POIS are.I don't remember about this theory, too much data here What you say is very possible. Some people have more energy and feel better after orgasm. For me the very good orgasms can cause the worst POIS episodes. Maybe because prolactin is also increased. We had a discussion about this study : "The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety" http://www.ncbi.nlm.nih.gov/pubmed/16095799
It stands to reason that better quality orgasms release more dopamine, which in turn inhibits the prolactin release, and possibly neutralises the symptoms of POIS.
Anybody think there may be something in this?
It seems possible that if POIS sufferers have an existing problem with low dopamine, even a normal secretion of prolactin will decrease dopamine enough to cause problems.
Martin, I think that what hurray means by "the very good [quality] orgasm" is not necessarily the explosive/exciting one but the orgasm that is more entwined with the "quality of the relationship".
Hurray, can you clarify?
Quote from: demografx on 28/09/2009 19:53:09
Would anyone here be interested in my approaching a testosterone manufacturer (like Androderm/Watson Pharmaceuticals) to see if they would be interested in conducting research, clinical trials into the use of testosterone as a way to alleviate POIS - for low- testosterone and normal-testosterone POIS sufferers alike? Feel free to post your answer here or to send me a Private Message.
I think we have nothing to lose if they conduct a research. I'm reticent with clinical trials, except if they show me something wrong in my body, maybe with androgen receptors, liver, estrogens, .. I was reading in some papers of a lab "elevated levels of T suggests poor utilization"(something like tht), if this is true blood T tests are BS and we need more research.
Thanks, Martin!
OK, if I understand the response to my post correctly, there are only two (2) people here who are possibly interested in a clinical trial/research study of POIS and testosterone. Which is not enough for me to approach Watson Pharmaceuticals, Inc. If I'm wrong, and you are interested, please let me know by posting your interest here or by PM! Thank you.
I am interested.
Hell i'll be their guinea pig if they want to try solutions that have a moderate % to kill me even. Anything to find a REAL viable consistent solution.
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