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Excellent report of your past and current treatments, urano. There's been a lot of discussion over the years here about possible causes of POIS including bacterial/viral or autoimmune causes. The way I see it there probably isn't one root cause that's the same for everyone. Hypothetically one person could have a nutritional deficiency or imbalance that lead to an imbalance in hormones which then somehow caused POIS. Another might have been sensitive to an environmental pollutant which damaged their immune system causing an abnormal autoimmune response to some component of semen. There's a lot of different possibilities.For myself I'm fairly certain I have a lot of inflammation or nerve sensitivity after an O, but I'm not sure what could be causing that. Also since I feel better with drugs that work on gaba and dopamine receptors it could be some sort of neurotransmitter depletion. For all I know just the quantity of semen I'm ejaculating could be draining nutrients or energy from elsewhere in my body.But I don't think of my symptoms as flu-like since during a flu all I get is nausea, which I never get from POIS.
For those who have flu-like symptoms 1-2 days after an O like me.Are you able to determine if they are a consequence of a real viral infection (flu-like), even with no fever?In other words, is it possible that for some people immune system is somehow temporary weakened after an O and this eventually "opens the gates" to infections?This is pretty much my feeling, but it could obviously be hardly proved and verified. I know that most of my clear infective episodes (generally viral at the beginning, bacterial eventually) are initiated or aggravated by sexual activity. It's been like this for 20 years. I feel that my POIS symptoms are like small viral infections resolved in 2-3 days, and reoccurring at the next episode.Alternatively, immune system has in my case an inflammatory response which makes my muscles sore and weak (exactly like flu does) even though there is no virus around, which can be of allergic or autoimmune nature.
Quote from: urano75 on 08/03/2013 21:37:17For those who have flu-like symptoms 1-2 days after an O like me.Are you able to determine if they are a consequence of a real viral infection (flu-like), even with no fever?In other words, is it possible that for some people immune system is somehow temporary weakened after an O and this eventually "opens the gates" to infections?This is pretty much my feeling, but it could obviously be hardly proved and verified. I know that most of my clear infective episodes (generally viral at the beginning, bacterial eventually) are initiated or aggravated by sexual activity. It's been like this for 20 years. I feel that my POIS symptoms are like small viral infections resolved in 2-3 days, and reoccurring at the next episode.Alternatively, immune system has in my case an inflammatory response which makes my muscles sore and weak (exactly like flu does) even though there is no virus around, which can be of allergic or autoimmune nature.The flu-symptoms after an O when I was 17-21 were quite severe. It typically started with sore throat (24 hrs after an O). 50% of time it progressed to bronchitis or pneumonia (in 3-4 days), which took about 2-3 weeks to recover. These 50% severe cases usually result from multiple O's within a day or two. My hormone was raging as in the case of any teenager. I am fairly certain in the first few days of flu-like symptoms, the infection is viral (no mucus, only dry cough, and not responding to antibiotics). It usually progress to bacterial infection after a week (lots of mucus, and responding to antibiotics very quickly).One reason that I no longer progress into a full-blown viral/bacterial infection any more is that my weight is now normal. I was very skinny between 17-21, but had gained about 40lbs in my early 20s and those bronchitis/pneumonia stopped at that time.I do think that my immune system is suppressed after an O for an unknown reason, in addition to the inflamation.
yes,urano75for me thats true, my immune system is weakened after O, and I suffer from symptoms of flu-like.... and i treat my self with Antibiotic.//you talk about me //
Romies, our respective scenarios look somewhat matching. For years I've been catching viral infections, which eventually paved the way to bacterial superinfections. I eventually passed so many winters with continued bacterial (e.g. strep) infections at the upper respiratory ways never resolved. One difference was that my infections became in time more kind of chronic low-grade rather than full-blown, with no fever but really dragging me down. I was reluctant to use antibiotics for them, as I would have fallen back in the same situation few weeks after and in the meantime I would have messed up my gut.
I think this is somehow related to adrenal weakness again. It's possible that my adrenals can't temporarily cope with the stress caused by an O, and eventually the immune system is weakened for awhile, e.g. because there is not enough cortisol around. It's possible that adrenals are depleted both by some kind of inflammatory/allergic process right after O, as they try to calm down the inflammation releasing more cortisol; or that they suffer from a temporary dopamine depletion which, for some reason (e.g. undermethylation), is not rapidly replaced.I mention adrenals again because I tend to have low cortisol signs after an O (low blood sugar, postural hypotension, temp drops) as I do after other too exhausting activities. But I think that adrenals in my case are just a link that has weakened after years of infections, inflammation, allergies etc, so it's possible there's some other issues behind/besides them to be addressed.
- Has the mechanism of why niacin works for many with POIS symptoms been understood or at least guessed? What's the percentage of folks here which benefit from niacin, and what is likely to be their weak link?
- Specifically in my case, given my history of hypoadrenia, allergies and depression, it is likely I am high histamine, undermethylating and low dopamine/serotonin: is niacin supposed to help in this situation, or would it make it worse?
- Is it necessary to wait for a flush before O to make it effective, or is it only a signal to be sure that niacin has saturated? If the flush occurs in an unpredictable amount of time, or it never occurs as it happened yesterday, it might hard to manage, how to make it happen approximately at a wanted time?
- Does regularly using a full complex of B vitamins as I do interfere with the effectiveness of niacin for preventing POIS symptoms?Many thanks!Andrea
I know I have dopamine depletion feelings after O. This, together with allergies and the fact I responded well to SSRI, probably places me in the category of undermethylators --> partially worked on this, but not systematically enough
I know I'm in need of chelating toxic elements (fluoride, arsenic) --> work in progress
I do hope I'm among the ones who can benefit from niacin. I can't try it right now, still down from previous O...
There may be something else other than cortisol. Cortisol is a known immune suppressor: the more cortisol you have, the less active your immune system is. http://en.wikipedia.org/wiki/CortisolSo I suspect something else is at play here.
I was on 5-htp daily to help the low mood after an O for a few years. But now I resolved it, 5-htp makes me very sedated, probably because excess 5-HT is converted to serotonin. Just be aware that 5-htp can be detrimental when you find a good regimen to recover from POIS
NADH 10mg + methyl-b9,b12 + Ginkgo
Here's my detox profile from genetic genie. (new test). It's based on my 23andme raw data.
Quote from: kurtosis on 11/03/2013 14:55:01Here's my detox profile from genetic genie. (new test). It's based on my 23andme raw data. What's a good resource to interpret these results?
Carnosine attenuates mast cell degranulation and histamine release induced by oxygen-glucose deprivation.