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Quote from: CCconfucius on 17/02/2011 19:19:59Those of us with just type iv reactions like myself will probally not react to a skinprick test because skinprick test is most efficient for type 1 allergies that involve breakouts and similar symptoms. Inorder to stimulate those cytokines that create iv reactions we gonna have to get doctors to get that semen to cytokines through intradermal injections. intradermal injections is the closest in similarity to what happens in the body when we do the big O. Because urethera is not on the skin it is inside the body.I totally agree with you !I guess I also have mostly the IV allergic reaction... and my first skin test (which wasn't an intradermal injection) was negative.We talked about it earlier but " inject semence directly into the IV type reaction" looks like "intralymphatic administration" (remind: about 2/4 months to cure from a tough allergy, compared to the long time of hyposensitization therapy)I talked about in a mail with Dr Prof Waldinger, and he said it could be hazardous, but he would contact me later to talk seriously about it. I talked about it with my allergist, she didn't answer yet...
Those of us with just type iv reactions like myself will probally not react to a skinprick test because skinprick test is most efficient for type 1 allergies that involve breakouts and similar symptoms. Inorder to stimulate those cytokines that create iv reactions we gonna have to get doctors to get that semen to cytokines through intradermal injections. intradermal injections is the closest in similarity to what happens in the body when we do the big O. Because urethera is not on the skin it is inside the body.
I think instead of going to private doctors we should all start contacting the head of allergy departments in university hospitals around our location to see who is willing to help
I reread dr waldingers paper and saw a pragraph that explains why probably a lot of us wont react to even Intra-dermal skinprik test. So pois = type 1 and typeIv reaction type1 = Ige accumulationstypeiv = T cell mediated disorders which means white blood cells going nuts and and it is antibody independent. Exact quote " The combined finding of local redness of the skin followed by a flu-like reaction, points to a combination of of TypeI and Iv hypersensitivity initiated by ejaculation. Morever , IC - intra dermal, inoculations of an allergen relates to specific IgE - mediated local reaction of the skin, whereas a flu - like syndrome resembles an acute phase response and is mediated by activated T-lymphocytes in contact with monocytes/macrophages to secrete acute phase peptides". So if you mostly get type IV reactions you might not get skin reaction. Might be why 29/33 reacted to skinprik test. Which leads me to conclude in addtion to skin test there should be a test related to T-lymphocytes activity after orgasm. Bjim said we should incorporate the other types of reaction type I - Vwe can do that by running test that includes all of them. Type I igeType II igm or igGtype III igGtype Iv T - lymphocytestype V - antibodies.
Quote from: CCconfucius on 19/02/2011 01:04:10I reread dr waldingers paper and saw a pragraph that explains why probably a lot of us wont react to even Intra-dermal skinprik test. So pois = type 1 and typeIv reaction type1 = Ige accumulationstypeiv = T cell mediated disorders which means white blood cells going nuts and and it is antibody independent. Exact quote " The combined finding of local redness of the skin followed by a flu-like reaction, points to a combination of of TypeI and Iv hypersensitivity initiated by ejaculation. Morever , IC - intra dermal, inoculations of an allergen relates to specific IgE - mediated local reaction of the skin, whereas a flu - like syndrome resembles an acute phase response and is mediated by activated T-lymphocytes in contact with monocytes/macrophages to secrete acute phase peptides". So if you mostly get type IV reactions you might not get skin reaction. Might be why 29/33 reacted to skinprik test. Which leads me to conclude in addtion to skin test there should be a test related to T-lymphocytes activity after orgasm. Bjim said we should incorporate the other types of reaction type I - Vwe can do that by running test that includes all of them. Type I igeType II igm or igGtype III igGtype Iv T - lymphocytestype V - antibodies. I already did an IGE test. It was too low. Normally allergic people have a high level of IGE. That's what I heard.
Quote from: demografx on 18/02/2011 05:42:27On February 18, 2007 John21courageously and eloquently posted here as the very first POIS-posterat a place which has now blossomed from that lone voice in the wildernessto a Worldwide Resource and Network for POIS sufferers! Thank you, John, who is still with us and active today! Everyone, Demo likes to give me credit for asking a question, but we all know who is really deserving of praise for the work done here. There are more than one, but Demo plays a pivotal role, and I thank him for what he does. When I asked the question I was experiencing POIS and had read online about Waldinger's patients, who had post orgasm "flu like symptoms", and I think that encouraged me. It dawned on me that there could be others out there, and now here we are. Thanks to every person who contributes in whatever capacity they can. Our numbers have increased since the release of Waldinger's reports. As POIS gets more recognized over time, who knows how many lives may be helped by your efforts. Happy anniversary!
On February 18, 2007 John21courageously and eloquently posted here as the very first POIS-posterat a place which has now blossomed from that lone voice in the wildernessto a Worldwide Resource and Network for POIS sufferers! Thank you, John, who is still with us and active today!
The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even during the Type IV reaction IgE could return to normal. (barring other allergies).
Quote from: CCconfucius on 19/02/2011 00:47:46I think instead of going to private doctors we should all start contacting the head of allergy departments in university hospitals around our location to see who is willing to helpAnd if we had a way to pay Dr. Waldinger to speak to them on our behalf, we might make a lot more progress, safely and efficiently. Also he could benifit some form his efforts.I'm sure his input could facilitate any interaction tremendously, and everybody wins.
Quote from: daveman on 19/02/2011 17:39:11The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even during the Type IV reaction IgE could return to normal. (barring other allergies).Or may be even about like 12 hours after. According to paper type IV reaction occcurs 12- 14 hours. I looked at my old test, which am sure i took 2-3 days after a big O,but still in pois. my ige,igg,igm,iga and lymphocyte subset panel all came out normal. I am guessing it is all normal because the allergic reaction is transient so days later all the immune cell activity has stopped but the body still has to recover from all the activity. Habibou how quickly did you do test.
Quote from: daveman on 19/02/2011 01:06:32Quote from: CCconfucius on 19/02/2011 00:47:46I think instead of going to private doctors we should all start contacting the head of allergy departments in university hospitals around our location to see who is willing to helpAnd if we had a way to pay Dr. Waldinger to speak to them on our behalf, we might make a lot more progress, safely and efficiently. Also he could benifit some form his efforts.I'm sure his input could facilitate any interaction tremendously, and everybody wins.Yeah that will be great he will have answers for their conclusions we dont have. But he is too busy for something like that to happen even if it was possible for us to raise enough money.
Quote from: CCconfucius on 19/02/2011 20:27:59Quote from: daveman on 19/02/2011 17:39:11The content % of IgE would have to be read on day 1 to 3 I imagine. Out of POIS it should return to normal, and even during the Type IV reaction IgE could return to normal. (barring other allergies).Or may be even about like 12 hours after. According to paper type IV reaction occcurs 12- 14 hours. I looked at my old test, which am sure i took 2-3 days after a big O,but still in pois. my ige,igg,igm,iga and lymphocyte subset panel all came out normal. I am guessing it is all normal because the allergic reaction is transient so days later all the immune cell activity has stopped but the body still has to recover from all the activity. Habibou how quickly did you do test. I made those tests 2 hours after an O
Hi Habibou,Yes, more news on the Silodosin.The first times I tried it (daily 8mg doses followed by O), it successfully stopped ejaculation but had the unpleasant side-effect of making me feel sleepy all the time. Not POIS sleepy, just plain "I want a nap" sleepy, no brain fog.I stopped taking the daily doses of Silodosin to see if it would work "on demand" (only taking the Silodosin before Os). My first experiment with this was last night, when I took half the recommended dose of Silodosin (1 4mg capsule) to see if it would be sufficient. Sadly, it wasn't - although the amount of semen ejaculated was far less than normal.I will try another "on demand" test next weekend, this time taking the full 8mg dosage. I hope this will be successful, as I don't want to take alpha blockers every day.
Maximum plasma concentrations for silodosin were reached on average 2.6 hours after dosing.
Silodosin is readily absorbed from the gut, and peak plasma concentration (Cmax) and area under the curve (AUC) for plasma concentration versus time increase linearly with dose [7]. Absolute bioavailability amounts to approximately 32% [8]. Food blunts Cmax and delays time to Cmax by about 1 h without affecting the AUC. This feature has been exploited by recommending the administration of silodosin with food, ideally during breakfast in the morning, to avoid plasma concentration peaks that could potentially be associated with adverse effects [7], [8], and [9].
Quite right - thank you Guthrie []one thing worth mentioning is that many (most?) members of the forum report having problems only after ejaculation - in their cases, sexual activity without ejaculation doesn't lead to them having POIS symptoms.
Quote from: hurray on 22/02/2011 07:50:35Quite right - thank you Guthrie []one thing worth mentioning is that many (most?) members of the forum report having problems only after ejaculation - in their cases, sexual activity without ejaculation doesn't lead to them having POIS symptoms.It's quite different for me, arousal causes POIS symptoms maybe ~ 20-30% that are short lived, but masturbation without ejaculation still leaves me in a dire state, and to get back to a state of normality would take longer than ejaculating. Also NE's ususally leaves me in a better state, rarely any POIS symptoms, strange.
DEAR ALL,PLZ READ CAREFULLY : Honestly speaking,,,,,and after tons & tons of research; consultations ; research; readings & trial & errors : iv personally & with respect to all opinions reached to that conclusion : For the general population (except listed exceptions below) POIS is nothing more than neurotransmitters brain deficiency related to excessive & prolonged stress & leading to Chronic fatigue syndrome like symptoms due to depletion of the body's key precursors & nutrients. Causes : Prolonged stress/ depression; poor nutrition; single/excessive sex; lack of exercise; pollution; anxiety; traumas & others.,,,Exceptions : People suffering from preliminary disorders such as : Autoimmune; adrenal exhaustion; hormonal imbalance; STDs * others,,,,,,Usually those suffering from any single or combined of any of the above will suffer additional symptoms like allergies; fever; anorexia; pain and depending on each and every case ( Remember each and everyone is very different while the human body itself is very complex---> That is why there can't be a universal cure for everyone,,,,because each case needs to be tackled; diagnosed & treated differently and that is exactly why we have so many different cases & claimed cures on this forum,,,because every tested/ cured member is different!) Treatment cure for the general population : Gradually replenish serotonin & other neurotransmitter deficiency using natural MAOIS; exercise; sun baths; healthy nutrition; stress reduction ; relaxation techniques& others,,,,,Use of homeopathy & herbal medicine to re-balance the system & reach homeostasis during exhaustion & recovery phases. Conclusion: To me & thx God after lots of suffering & hard work POIS is a closed case now! Though I still suffer from undesired symptoms from time to time ; Iam 100% aware of what it is going on with my system & specifically inside my brain . In addition I fully understand the thirst of POIS sufferers like me to learn & know more & get into the nifty tiny details,,,,but trust me the problem AND solution for the general population,,,,is much much MUCH simpler than it seems,,,,,Sometimes we drawn into the details & forget the big picture,,,,,,and that has in my opinion has been the case for POIS ,,,and again with my deepest respect to all researchers; specialists; active members; & moderators of this forum,,,,,get well everyone. Regards,