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New Theories / Re: Post Orgasmic Illness Syndrome (POIS)
« on: 24/01/2014 02:14:05 »Hello Acronym
I appreciate your questions and recruitment, I have answer to all of them .
Starting with- infertile men, have high ASA counts, do not feel any symptoms of POIS is because they have imperfect blood-testis junction. So blood comes in contact with sperm cell,develop ASA and harm it. People with such problem get infertile. Also they develop High ASA count. They do not feel any cognitive problems we POISers feel because their sperm has 'not' entered bloodstream (Fight goes on in testis). So no vasoconstriction is ordered by the body, therefore they have no cerebral hypoxia.
People with high ASA can be either infertile or have POIS. Both POIS and infertility can cause to develop elevated ASA levels. People with High ASA and cerebral hypoxia should have POIS. I will search on for such people.
-->Niacin Before an O,
Niacin Helps before an O as, When one has took niacin before an O it orders Vasodialation, now After ejaculation body orders for vasoconstriction, So both the forces get equal and opposite and cancel each other. POISer feels normal As bloodflow remains normal. Vasodialating effects of niacin are for long time and it maintains normal bloodflow till POISer gets relieved from symptoms.
--> Taking Niacin After an O.
When body Is already vasoconstricted after an O, many narrow blood channels like that in brain get even more narrowed, Bloodflow to those channels has already decreased So that amount of niacin required in those channels to create it's vasodialating effects gets insufficient. Take it this way, Earlier (before an O) suppose 2mg of niacin entered a channel and created helpful effects , now due to vasoconstriction and narrow blood channel say like 0.25mg of niacin could enter that channel. Still some vasodoalation is there but it is not enough and we may feel cerebral hypoxia. And By channels I mean arteries to brain. So , taking niacin after an O, Both the forces are not equal, vasoconstriction is dominant. Therefore It is required that Niacin must be taken before an O. in order to elevate from POIS symptoms.
POIS from puberty is essentially 'plumbing problem' but for some people in their 40's that have developed POIS, Many factors may be involved that caused semen spill in them . It may be that their prostate has start the spill or seminal vesicle. tough question though, Place of Spill should be determined experimentally and spill site may differ from person-person.
MrVat7
I actually think that the vasoconstriction theory is very possible, and is likely to contribute to most of the cognitive symptoms. Why its plausible is that many actually feel pressure/headaches inside the head along with the cognitive symptoms, which imply a physical manifestation/obstruction that's contributing to the symptoms.
Although I have asked a friend, who is a med student, whether vasoconstriction can be the main cause, but he told me it's unlikely, as the vasoconstriction/cerebral hypoxia would cause stroke-like symptoms.
But I think this is clear - instead of just changes at the neurotransmitter and chemical level, there's also some physical changes to the brain during POIS.