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Quote from: Vincent M on 10/02/2013 17:45:02Correction to my post about my b-vitamin trial. I had actually been taking the b-complex 7 days before I started ALC and for 24 days total. I think that was a bit too long to be taking that much once a night since it seemed I was starting to get odd tiny pain flashes in my joints that I previously didn't have. The past 2 days I stopped taking it and this sensation disappeared but my POIS symptoms still are generally improved.That's odd. You seem to be well within safe levels of b6. Just check again how much you're taking? Methyl-b12 can cause some nerve tingling but that may not be a bad thing in all circumstances as methylcobalamin / methyl-b12 is often used to treat diabetic neuropathy (nerve damage). It seems that neuropathy itself resembles a tingling sensation (initially) while the repair of nerves that were damaged may also trigger an initial "tingling" sensation. Here's a paper http://www.sciencedirect.com/science/article/pii/0022510X94902909QuoteUltra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. Tetsuya Watanabe, Ryuji Kaji , Nobuyuki Oka, William Bara and Jun Kimura Department of Neurology, Kyoto University Hospital, Shogoin, Sakyoku, Kyoto 606-01, Journal of Neurological Sciences, Vol 122, Issue 2, April 1994, Pages 140–143
Correction to my post about my b-vitamin trial. I had actually been taking the b-complex 7 days before I started ALC and for 24 days total. I think that was a bit too long to be taking that much once a night since it seemed I was starting to get odd tiny pain flashes in my joints that I previously didn't have. The past 2 days I stopped taking it and this sensation disappeared but my POIS symptoms still are generally improved.
Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. Tetsuya Watanabe, Ryuji Kaji , Nobuyuki Oka, William Bara and Jun Kimura Department of Neurology, Kyoto University Hospital, Shogoin, Sakyoku, Kyoto 606-01, Journal of Neurological Sciences, Vol 122, Issue 2, April 1994, Pages 140–143
http://curezone.com/forums/am.asp?i=1687495 here is an interesting article revealing properties of B3/niacin to fight candida.
What are some systemic symptoms of candida overgrowth? Symptoms that can be caused by yeast (but may also have other causes) are: • Chronic fatigue, or fatigue in mid-afternoon or after meals • Food cravings, especially for sweets • Depression, brain fog, poor concentration, irritability • Hyperactivity and learning disabilities in children • Loss of sexual desire, dry vaginal area • A reaction or aversion to perfumes, dust, cut grass, tobacco smoke • Allergies or hypersensitivity to foods, chemicals, molds, pollen, perfume, tobacco smoke • Immune impairment, autoimmune disorders • Headaches, stiff neck and back, joint pains • Alternating constipation and diarrhea, or either one • Bladder infections, vaginitis • Sunlight sensitivity, light hurts eyes • An overall feeling of not being well • Bloat and gas. Yeast produces gas and thus bloat, like the gas bubbles that cause the rising of bread.
My current daily supplement routine.upon wake-up: Now-brand NADH 10mg (rocket fuel indeed). no eating for 25-30 mins.after breakfast: Fish oil, Ginkgo 120mg, Vitamine D 2000IU, Methyl-Guardx1 capsule Wellbutrin 100mg SR (being taking this for a year before I discovered the POIS thread)after lunch: Ginkgo 60mg, Vitamin C, Multi-vitaminbefore sleep: Now-brand Arginine+Ornithine 500/250mg x 2 (to reduce ammonia) Loratadine 10mg, ZMA(1 capsule only: 10mg zinc, 5mg Pryidoxine HCL, 150mg Mg), p5p 50mg.additional Ginkgo, VC and 1 Methyl-Guard after orgasmI would say this routine eliminated 90% of the cognitive symptoms.
Wow. good to know that other people are getting the same relief. You have symptoms which are quite similar to mine and you seem to be taking similar supplements. I actually simplified my routine a lot which now consists of- a fish oil with olive oil and lemon oil. This has none of the rancid taste of some fish oils. - a multivitamin with active b vitamins, coq10 and other antioxidants. I get about 400 mcg of methylfolate / day and about 500mcg of both adenosylcobalamin and methylcobalamin. (as I've posted before, I have a theory that methylation defects can cause inflammatory disease and active b vitamins particularly folate and b12 can help reduce or reverse these symptoms)- blueberry extract with pterostilbene. Sometimes I actually just eat blueberries (old fashioned) but they appear to help reduce cognitive symptoms. I couldn't tell you whether it's the methylated b vitamins, the anthocyanins or the pterstilbene in blueberries that works. Maybe it's all these but blueberries definitely seem to help. I'm reaching for the NADH less these days but, yes, I found it useful in reducing fatigue. I believe the improvement we're noticing from NADH is increased energy and increased glutathione production. I also worry about fluctuating homocysteine levels that may contribute to the dull headache that some of us get. Just some thoughts. I realise that none of this is conclusive.
what is test name for gene thing?
I'm reaching for the NADH less these days but, yes, I found it useful in reducing fatigue. I believe the improvement we're noticing from NADH is increased energy and increased glutathione production. I also worry about fluctuating homocysteine levels that may contribute to the dull headache that some of us get. Just some thoughts. I realise that none of this is conclusive.
Quote from: kurtosis on 18/02/2013 12:18:04I'm reaching for the NADH less these days but, yes, I found it useful in reducing fatigue. I believe the improvement we're noticing from NADH is increased energy and increased glutathione production. I also worry about fluctuating homocysteine levels that may contribute to the dull headache that some of us get. Just some thoughts. I realise that none of this is conclusive.I notice that you are 1298C +/- and I am 1298C+/+. my current understanding is that 1298C+ leads to low BH4, which in turn reduces L-DOPA and 5-HTP production in the brain. NADH recycles BH2->BH4, thereby increasing DA, 5-HT, NE and E levels..You think glutathion pathway is more influential?BTW fluctuating homocysteine levels is induced by NADH intake?Thanks again!