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Quote from: demografx on 13/02/2011 00:04:45Quote from: hurray on 12/02/2011 13:56:32My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.Should be interesting!Silodosin side effects:http://www.drugs.com/sfx/silodosin-side-effects.htmlIt reports retrograde ejaculation as a side effect in 28%. Would that mean that it only produces spermless semen in 28% of those who use it?
Quote from: hurray on 12/02/2011 13:56:32My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.Should be interesting!Silodosin side effects:http://www.drugs.com/sfx/silodosin-side-effects.html
My supply of Silodosin (stops semen emmissions) has arrived. Will take for a few days and then see what happens.Should be interesting!
Sorry Demo, I'd like to see hurray's semen too!
Well that disturbs me Daveman altering the blood flow to the brain had a direct effect on my pois symptoms???Symptoms of low thyroid function include:Fatigue, exhaustion, feeling run down, sluggish, lethargicDepression, restlessness, moods swings, feelings of sadness, feelings of worthlessnessLoss of interest in normal daily activitiesPoor concentration, poor memoryAches and painsFrequent infectionsSlow pulse and/or low blood pressureDizziness, vertigo, and/or light-headedness with or without headachesCommon symptoms and signs of hyperthyroidism-Palpitations-Heat intolerance-Nervousness-Insomnia-Breathlessness-Increased bowel movements-Light or absent menstrual periods-Fatigue-Fast heart rate-Trembling hands-Weight loss-Muscle weakness-Warm moist skin-Hair loss-Staring gaze Ok so pop quiz lol I dont know about you but my pois symptoms include every single thing on both of these lists how is it possible to have the symptoms of two thyroid diseases that are polar opposites of eachother? what would could cause the thyroid function to swing back and forth like that?
With regard to the question of 'retrograde ejaculation', here is a more recent article:http://www.europeanurology.com/article/S1569-9056%2810%2900053-9/fulltextIt says:QuoteRetrograde ejaculation does not appear to be particularly bothersome. Whereas >20% of patients reported this adverse effect, only 3.9% discontinued treatment because of it. Furthermore, this effect is fully and promptly reversible within a few days after discontinuation of treatment [8]. The most likely explanation for the difference between the occurrence rate and discontinuation rate is that patients with lower urinary tract symptoms (LUTS) often suffer from initial sexual dysfunction, including diminished ejaculation, independent of any subsequent treatment [16]. This effect was historically called retrograde ejaculation, because it was believed that failure to ejaculate was the result of smooth muscle relaxation in the prostate, urethra, and bladder neck leading to abnormal urethral flow, as is the case after transurethral resection of the prostate. However, recent studies have shown that the mechanism is rather a loss of seminal emission resulting from relaxation of the vas deferens [17], and [18]. Thus, the correct term for the observed effect is anejaculation. An unresolved issue is whether anejaculation has an impact on the quality of orgasm. According to a preliminary randomised, double-blind crossover study in 15 healthy volunteers, orgasm is preserved regardless of ejaculatory dysfunction [19].So it does seem that it is not actually 'retrograde ejaculation.'
Retrograde ejaculation does not appear to be particularly bothersome. Whereas >20% of patients reported this adverse effect, only 3.9% discontinued treatment because of it. Furthermore, this effect is fully and promptly reversible within a few days after discontinuation of treatment [8]. The most likely explanation for the difference between the occurrence rate and discontinuation rate is that patients with lower urinary tract symptoms (LUTS) often suffer from initial sexual dysfunction, including diminished ejaculation, independent of any subsequent treatment [16]. This effect was historically called retrograde ejaculation, because it was believed that failure to ejaculate was the result of smooth muscle relaxation in the prostate, urethra, and bladder neck leading to abnormal urethral flow, as is the case after transurethral resection of the prostate. However, recent studies have shown that the mechanism is rather a loss of seminal emission resulting from relaxation of the vas deferens [17], and [18]. Thus, the correct term for the observed effect is anejaculation. An unresolved issue is whether anejaculation has an impact on the quality of orgasm. According to a preliminary randomised, double-blind crossover study in 15 healthy volunteers, orgasm is preserved regardless of ejaculatory dysfunction [19].
Thanks for the info, Demo, Guthrie and Daveman. I am feeling a little light-headed on the Silodosin, but nothing too dramatic. It's a shame it's only men who seem to be interested in my semen []I'm taking the recommended 8mg per day - will have more news in a day or 2.
It's a shame it's only men who seem to be interested in my semen []
Quote from: hurray on 13/02/2011 11:48:21Thanks for the info, Demo, Guthrie and Daveman. I am feeling a little light-headed on the Silodosin, but nothing too dramatic. It's a shame it's only men who seem to be interested in my semen []I'm taking the recommended 8mg per day - will have more news in a day or 2.Hurray, can I ask how you were able to obtain the Silodosin? Did you have to have a doctor prescribe it for you?
OK, I've given my Silodosin (in my case a generic version called Silodyx) a test!First, the semen - there wasn't any! So it's certainly doing its job there. There was no pre-cum (Cowper Glands fluid) either. I didn't spend more than 10 minutes or so on the "experiment", so it's possible that pre-cum may have arrived later. It wasn't retrograde ejaculation, no semen appeared in my urine later on, so in my case it was genuine anejaculation. The orgasm itself was a bit odd - the feeling within my brain was of far less intensity than a normal O, although the muscles "downstairs" were contracting as per normal during the O.It's been several hours since my O, and there hasn't been any brain fog - which is great news for me! However, I am not going to celebrate too soon - maybe 1 in 5 of my Os are relatively trouble free, so I'll keep testing it and hopefully it will keep working for me.It's not an ideal solution - in my case, there was no discomfort at orgasm, but not much pleasure either. Will keep you up to date on my progress.
2 days - I meant to wait the full three days, but my curiosity got the better of me.I want to use it for a few weeks before I really get enthusiastic about its use as a possible means of stopping the POIS allergic reaction. But it's all looking good so far []Wikipedia reckons that it has a half-life of only 13 hours, so I don't think it's necessarily the sort of drug that you need to take every day. It's possible that it may work "on demand", as in you only need to take it before orgasm. If you were using it to prevent conception, naturally you would take a daily dose to avoid any lifelong "mishaps" []
hurray- Just wanted to let you know I'll be looking forward to your updates on the silodosin. Sounds like this thing could be exactly what we need.
Sorry, I wasn't trying to skirt any laws--I was just asking whether it is a prescription-only drug. I guess the answer is 'yes'!
hurray do you know what happens to build up of sperm that doesnt come out.
ANNOUNCEMENT OF PROF. DR. MARCEL D. WALDINGER January 17, 2011Dear Members of this POIS Forum, For reasons of confidentiality regarding the publication of our article and in order to get the required attention of the media, it has been necessary to maintain strict silence the last few months on the results of our research. Before explaining our results, I would like to compliment Demografx for his understanding of how things are going when an important scientific publication is at hand. And I also would like to compliment and congratulate Demografx for his impressive accomplishment to have developed this website and making it to a success. No doubt, that probably all of you, will agree with that.Today, I publish two articles on POIS in the Journal of Sexual Medicine. The first article is about the characteristics of POIS and our hypothesis. The second article is about its treatment.After 8 years of research, we have found that the various complaints of POIS are due to an immunological reaction of a man to his own semen. Interestingly, as long as the semen is stored in the testis there is no problem. However, as soon as the seminal fluid is released towards and into the urethra the various complaints will occur within a few minutes, and in the majority of our population of men within 30 minutes after ejaculation. But there are also men in whom the complaints start after a few hours.Briefly, POIS actually appears to be a systemic immune reaction that occurs only at the moment that semen is ejaculated towards or through the urethra. In order to get hard evidence for this, we have performed a skinprick test with a man’s own (but very diluted) semen in his forearm. In more than the majority of men this has resulted in a positive allergic skin reaction and vague complaints of POIS.But by saying this, I have to warn all of you. Don’t do this by yourself as a sort of experiment with your own body without medical expertise. Own semen injection may lead to serious allergic reactions and even a (anaphylactic) shock, e.g. acute severe and life-threatening lowering of blood pressure, urging for acute medical aid. Skinprick testing is only safe in hands of a medical professional and with adequate equipment in case that an emergency may happen. The best approach is that a physician performs a skinprick tests with diluted semen in a well-equipped hospital.The procedure and the results of this skinprick test is described in the first article. After we had found this cause, we decided to treat POIS by hyposensitization treatment. Injections of diluted toxins is well known in allergy clinics and known as “hyposensitization”. In fact, treatment of POIS follows a similar procedure but instead of a diluted pollen extract we use diluted semen of the man himself.This treatment consists of regular (weekly) injections in the skin of your own very diluted semen for a few years. By doing this the body looses its immune reaction against the semen. And yes, you have read this well, this treatment lasts a few years. It requires a lot of patience of both the patient and doctor to complete the whole injection program. In the second article, we have described two men who were the first to have undergone this treatment. After a few years, this treatment resulted in a significant diminishment of their complaints. Currently, we also treat other men by hyposensitization but the results of these men are not finalized yet.In summary, our research has shown that POIS is caused by an immunological reaction to a man’s own semen, that a skinprick test with a man’s own semen confirms this diagnosis, and that hyposensitization treatment diminishes the frequency and intensity of the complaints.Still, we have a lot of questions about all sort of details. This is normal in science. The results of good research always raise new questions.In recent years, I have formed a dedicated team of researchers on POIS in the Netherlands. Probably, there is no other research group in the world, that is so much focused on POIS as our team. We continue our research as I would like to find out whether it is possible to cure POIS by medication. This is not easy, as such research costs a lot of money. Sofar, we have financed our research by our own private money, as there are no institutions that share a serious interest in POIS research. But with the publication of the current key papers on the POIS issue, showing that POIS is a real medical disorder, the odds may rise that financiers become reassured to invest in POIS research. On the short term, I would like to investigate the characteristics of POIS around the globe since I believe that POIS is a worldwide post-ejaculatory disorder. For that purpose, I would like to send a questionnaire to all of you, and to talk to each of you personally by telephone to discuss your complaints. This will take time and patience from all of us. As most of you are probably interested to read our publication, I propose the following: If (each of) you will send me an e-mail, stating that you have read this message on the Forum, and that you are willing to fill in a questionnaire, I will send you the copies of both articles by return through email. At a later date, I will send you the questionnaire which, after having filled in, you should send me back by e-mail.My e-mail address is : prof.dr.waldinger.pois@gmail.comYou can also look at my website: www.pois-info.com or www.post-orgasmic-illness-syndrome.comWith best regards, Prof. Dr. Marcel D. Waldinger