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the water potential in a healthy host cell is different from the water potential of the infested cell.
Quote from: puppypower on 01/03/2020 17:20:01the water potential in a healthy host cell is different from the water potential of the infested cell.Do you have evidence for that claim?
When the water is saturated, in terms of interaction with other things, the activity is 0.
It disorientates the viral sensory systems as the virus DNA sleeps.
So, that's a "no" then.Quote from: puppypower on 02/03/2020 22:09:01When the water is saturated, in terms of interaction with other things, the activity is 0.So, because, the water is saturated with collagen- a fairly common and low solubility protein, the activity of water in any human is zero.Or you are wrong.Quote from: puppypower on 02/03/2020 22:09:01 It disorientates the viral sensory systems as the virus DNA sleeps.I'm reminded of a quote I saw on the web: "don't anthropomorphise the electrons; it annoys them."The idea of sleeping DNA and viruses with sensory systems is bizarre. A virus has no brain and no nerves.
If there is enough collagen to tie up all the aqueous hydrogen bonding the answer is yes. But there is not that much collagen in living systems. Most of the water in living system is bonded to other water; still active.
Quote from: puppypower on 03/03/2020 22:02:39 If there is enough collagen to tie up all the aqueous hydrogen bonding the answer is yes. But there is not that much collagen in living systems. Most of the water in living system is bonded to other water; still active.There is clearly enough to saturate it.Because, if the water in your body wasn't saturated with collagen then collagen would dissolve into it from, for example, blood vessel walls.It's also pretty much saturated with calcium phosphate.And your use of "sensory" is somewhere between unorthodox and wrong.It's like describing velcro as sensory.There is literally no "sense" involved.
The Corona Virus is a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses ranges from approximately 27 to 34 kilo bases, the largest among known RNA viruses. Helical symmetry is somewhat unusual for a positive sense single strand RNA. It is much more common for negative sense single strand RNA.
In terms of the water-oil analogy this spiky configuration tell me the spikes are more on the water side of the water-oil equilibrium. If they had been more reduced or on the oil side of equilibrium, they would be more balled up, instead of extended in terms of linear surface area
Quote from: puppypower on 05/03/2020 11:53:22 In terms of the water-oil analogy this spiky configuration tell me the spikes are more on the water side of the water-oil equilibrium. If they had been more reduced or on the oil side of equilibrium, they would be more balled up, instead of extended in terms of linear surface areaDid it occur to you that they might just be stiff?
The Phosphate groups are chaotropic which is similar to the impact of potassium. These will disrupt the cooperative hydrogen bonding on the spikes and diminish their activation energy affect needed for entry. It will make it harder of the virus to enter cells.
Quote from: puppypower on 09/04/2020 12:59:41The Phosphate groups are chaotropic which is similar to the impact of potassium. These will disrupt the cooperative hydrogen bonding on the spikes and diminish their activation energy affect needed for entry. It will make it harder of the virus to enter cells. Great news.I will continue to drink cola which will provide a lot more phosphate than chloroquine pills ever would.Did it not occur to you that you are focussing on utterly the wrong thing?BTW, the mechanism of action of chloroquine is already known. Has been for years.https://www.ncbi.nlm.nih.gov/pubmed/8361993And there's a credible mechanism for it working in the case of coronavirus.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/Whereas your bizarre view is that the stuff miraculously holds onto the phosphate ions in solution, but then magically gives them up inside the virus where they do something- which is odd because viruses already contain lots of phosphate.
You must have misunderstood. The phosphate groups impact the surface of the corona virus.
Phosphate is chaotropic and will disrupt the aqueous cooperative hydrogen bonding on the virus surface,
The net affect is the bulk circulating water of the body is shifted more toward the oil side of the water-oil equation.
The fact that virus impact the elderly, more than the young, implies that the young, in general, are more on the water side of the equilibrium.