41
Physiology & Medicine / Can tumours be destroyed by blocking cancer cell glycolysis?
« on: 23/02/2015 03:35:50 »
Perhaps it is possible to destroy a predominant enzyme within a tumor cell via magnetic resonance.
Targeting and destroying by resonance the Pyruvate Kinase M2 enzyme would stop glycolysis in cancer cells and thus destroy them. Normal cell mitochondria respiration's glycolysis pre-step uses Pyruvate Kinase M1 and should not be affected due to the M1 enzyme having a different physical structure from the M2 enzyme and thus a different resonant frequency. It may be possible to kill the tumors in typical MRI slices using a MRI concept type of machine; not necessarily resonating hydrogen, but resonating whatever is required in the M2 target enzyme to break it apart.
The machine's superconducting magnetic coil and gradient coil would both surround only the tumor area and have a variable physical size outside the body.
Assisting explanation:
http://www.howequipmentworks.com/mri_basics/#hydrogen_nuclei
This would provide a gradient of increased resonant frequencies, generating typical MRI slices of the tumor. This gradient of increased resonant frequencies would protect any other Pyruvate Kinase M2 enzymes outside the MRI slices (if present, but unlikely, in the area) since they would have a lower resonant frequency. These gradient resonant frequencies could now be overdriven by a RF coil causing a percentage of these Pyruvate Kinase M2 enzymes to break apart. Then the process would be repeated for a specific dose to the patient until the tumor is destroyed.
Targeting and destroying by resonance the Pyruvate Kinase M2 enzyme would stop glycolysis in cancer cells and thus destroy them. Normal cell mitochondria respiration's glycolysis pre-step uses Pyruvate Kinase M1 and should not be affected due to the M1 enzyme having a different physical structure from the M2 enzyme and thus a different resonant frequency. It may be possible to kill the tumors in typical MRI slices using a MRI concept type of machine; not necessarily resonating hydrogen, but resonating whatever is required in the M2 target enzyme to break it apart.
The machine's superconducting magnetic coil and gradient coil would both surround only the tumor area and have a variable physical size outside the body.
Assisting explanation:
http://www.howequipmentworks.com/mri_basics/#hydrogen_nuclei
This would provide a gradient of increased resonant frequencies, generating typical MRI slices of the tumor. This gradient of increased resonant frequencies would protect any other Pyruvate Kinase M2 enzymes outside the MRI slices (if present, but unlikely, in the area) since they would have a lower resonant frequency. These gradient resonant frequencies could now be overdriven by a RF coil causing a percentage of these Pyruvate Kinase M2 enzymes to break apart. Then the process would be repeated for a specific dose to the patient until the tumor is destroyed.