21
New Theories / Re: Post Orgasmic Illness Syndrome (POIS)
« on: 22/02/2013 01:25:40 »Nightingale,
I am not completely out of the woods yet.. The recipe is quite complex, so if I forget one or two ingredient, I sometimes still get some POIS symptoms, but for 12-18 hrs only, as opposed to 4-5 days before.
Your COMT, VDR and MAO A profile is almost completely opposite from mine. so I guess your are more of the over-methylation type. Maybe taking Niacin before and after an O will help to mop up extra methyl and lessen the crash?
I do think there are several sub-types of POIS. maybe there is a over-methylation type, where too much dopamine was generated. Dopamine response curve is U-shaped. too much DA does degrade cognitive and may also causes dopamine receptor to down-regulate, and causes a hang-over for 4-5 days after..
Dopamine is an especially interesting part of this for me. I have yet to find someone else to responds this way when they have 2 O's in a close timespan, especialy under 2 hours: The second O is harder to achieve, but it's intensity is FAR greater, both in POIS symptoms AND in pleasure. I'm sure you know dopamine surges for an O. It's like taking a illicit drug that leaves me senseless. I often will lie there in what feels like a semi-coma. It can be hard to move my self, as it's like I'm half-paralyzed. It seems similar to what sufferers of cataplexy (sleep paralysis) experience, but I'm able to move with sustained effort. Some mornings after when I was depressed and O'd more then once a day, it would take me 15 minutes longer to get out of bed because of the paralysis state. I wonder how much histamine was surging through my system at those times...
I'm having Phe, ammonia, Heavy metals, and maybe sulfur levels tested this weekend. I'm especially curious about ammonia, since after eating meat lately I'm getting this wave of brainfog and loss of concentration.
I have such days of low-functioning, I can't even learn how to make the next choice in my treatment. I would love to complete my IT degree and finish my bachelors some day soon!
EDIT: I wonder, too, if my having to take 1.5g of niacin to achieve a flush now has something to do with an excess of methyl? My first times trying niacin didn't require nearly as much, but early on I noticed I needed about 200mg to get a real flush were most were needing 100-150mg. It quickly climbed to where I had to buy 500mg niacin tablets. Actually, my flush isn't very strong anymore and I'm getting less reduction in symptoms, I might bump it up to 2g soon.