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New Theories / Re: Post Orgasmic Illness Syndrome (POIS)
« on: 19/07/2013 02:14:12 »
I was planning on taking vitamin E to reduce prolactin but what is its effect on acetycholine levels, receptors and synthesis?
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I am not cured, ejaculating at daytime leaves me sleepy, fatigued, and some brain fog for the rest of the day. Time for mineral ratio change, I shall introduce taurine to the mix next, also the process of testing is taking a long time. Despite the HUGE improvement of my symptoms, the fatigue still ruins my freedom Testosterone increased to 5.12 ng/mL but it is still damn low. Free testosterone 20.21 pG/mL .
somebody loses weight after ejaculation?Yes, I loose weight when POIS strikes.
c Yours kima
The immune system participates in the regulation of ACTH production via interleukins (IL)-1, IL-6, tumor necrosis factor (TNF)-alpha and interferons alpha and gamma, which affect the axis at all levels i.e. hypothalamus, pituitary, and adrenal cortex. If TNF-a cytokine binds in alot of ACTH receptors, in times of stress the adrenals cannot produce enough cortisol since ACTH receptors are blocked, even if there is enough CRH produced by hypothalamus and ACTH from pituitary gland after secks. This is a domino effect, excess acetycholine activates mast cells to release pro inflammatory histamines through cholinergic receptors and low testosterone along with suppressed testosterone due to prolactin, estrogen,etc. cause an unregulated inflammatory response. Nutrition is also important and an anti acetycholine regimen mineral consumption plus providing hormonal building blocks can help too. The fact that prednisone and Androstenedione reduce my symptoms greatly is no coincidence.The though part is proving my theory, how can I prove this and is there something else is the question.
TNFa in particular is predominant in Crohn's disease, which I happen to suffer from. The adrenal glands are end-organs that are merely responding to what they are told to do. If they are not producing enough cortisol, perhaps it is not the adrenal glands that are "fatigued" and dysfunctional, but rather other elements of your physiology that needs addressing.
Same as Kurtosis, I dont think anyone has myasthenia gravis here at the clinical form of it. And also I think we are talking only about one case of POIS here, with low acetylcholine and low DHT.I know that MG is not POIS. But I am looking for ways to explain a upper right back and sometimes arm pain that is so far not related to inflammation, nor tears, nor pinched nerves (I have been suffering 3 years of it regardless of POIS), POIS and Crohn's disease. Maybe its vasculitis but I still can't find indications of it.
One time I was taking too much zinc, and my progesterone went way up and my DHT went way down.
My estrogen was down my dht was down , and my progesterone up.
So at the same time I was thinking and experimenting with acetylcholine , myastenia gravis manganese and acetylcholine connection with DHT.
I took 2 pills of saw palmetto, in 15 minutes I had POIS without even sex.
So I poisoned myself on purpose .AHAHA Since saw palmetto lowered my low DHT
then I took 50 mg of manganese. POIS was gone within 1 hour completely
I am wondering how many people got POIS from Finasterid.
Since in low DHT layout , that is exactly what that is
I dont recommend anyone screwing with your neurotransmitters, niacin raises acetylcholine , lowers thyroid hormones and progesterone.
You need to get balanced, only that way you can help yourself...You need to chelate free copper, since that interferes with manganese and zinc.
To do all that, you need to lock your metabolism in the middle, it is very hard to do. Since no matter what you are taking you will go from side to side, and you will get POIS in both sides.
Allergy is not the only thing that can cause histamine release from mast cells, examples are opioids and acetycholine. There is a presence of cholinergic muscarinic receptors on mast cells, but there is not many info available about that. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1279398/I just got my tests back from the doctor. Was a blood test and result is I dont have IgE antibodies against sperm and doctor concluding can not be allergy.
What a disappointment, in a way.
I want to recall an important point.
There are 2 ways (at least) to explain allergic symptoms in Pois.
First is allergy to sperm. But IgE are the mediators for type I allergy only.
Second is histamine release after orgasm.
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For the first time I have a new symptoms in Pois Day 1, blurred vision.
It seems linked to general fatigue and visual fatigue. It was a tiring week for me.
At wake, my long distance view is blurred. The symptom is slowly decreasing after some hours.
The vascularity of my intestines was normal after a colonoscopy study. Also, the most probable cause of my Crohns was heavy antibacterial medication when I was six years old after a Vesicoureteral reflux surgery( because Secondary vesicoureteral reflux is due to a urinary tract malfunction, often caused by infection.) promoting bad bacteria proliferation and a violent immune response or that I have Celiac disease excacerbated by Nsaids. I used to have asthma though, around that age too, vasculitis can cause that. I have no pysical direct indications of vasculitis, and I can't afford testing vasculitis.... I need now to fix the hormonal disaster Crohn caused. Reducind estrogen to bring down DHT and up Testosterone to healthy levels is the first step (I am a 18 year old with low testosterone, I already tested myself).
If you really have low testosterone, that too, like Crohn's, is possible via small-vessel vasculitis , ( rather than a consequence of Crohn's ) ... http://www.ncbi.nlm.nih.gov/pubmed/18609261( fake an illness?)
Faking anything is just going to muddy the waters and damage your relationship with your healthcare providers and health insurance, faking is a very bad idea.
Indeed, a CT scan was made to explain if I had a flare up (immune system attack causing inflammation, etc.). Maybe malabsorbtion of nutrients was the POIS problem all along. This could have caused Now I need to find a way to justify the medical plan to cover further testing ( fake an illness?). I need now to fix the hormonal disaster Crohn caused. Reducind estrogen to bring down DHT and up Testosterone to healthy levels is the first step (I am a 18 year old with low testosterone, I already tested myself). Then find the mineral dosing appropriate to reduce acetycholine and increase GABA, wich requires testing. Not very sure about the testing required for finding out how to balance neurotransmitters though.I have some recent tests here done for testing looking for a way to explain weight loss ...
You previously said you have Crohn's , weight loss is typical in that disease because of malabsorption, and/or reluctance to eat because it causes pain ...Quote from: wikipedia.orgCrohn's disease may manifest as weight loss, usually related to decreased food intake, since individuals with intestinal symptoms from Crohn's disease often feel better when they do not eat and might lose their appetite. People with extensive small intestine disease may also have malabsorption of carbohydrates or lipids, which can further exacerbate weight losshttp://en.wikipedia.org/wiki/Crohns_disease#Systemic
Denied,High DHT apparently fits in with the rest of the puzzle. DHT is the one that does most to promote erections, especially spontaneous ones and those experienced during REM sleep and wet dreams. I was looking for an answer to that, you indeed have helped me. I was suspecting high acetycholine for quite some time, but could not find a way to explain every single reason, how it worked and how to fix it naturally. Now I think I know what to do.
If you carefully read this forum you would know that I posted different programs for different POIS cases , it looks like you are taking one of my postings. I hope it matches your body chemistry. Manganese raises acetylcholine, which raises DHT. Manganese raises sodium level. Zinc chelates manganese. To take manganese and zinc you need certain ratio. The most important ratio in your cell is NA/K . So if you know where you are on that ratio, then you can take minerals.
They are 2 cases, low acetycholine high testosterone , low DHT ----POIS is caused by low DHT. Try to give low DHT person saw palmetto..you will go right into POIS.
secondly, there is high acetylcholine , low testosterone high DHT high estrogen ---symptoms are caused by low testosterone.
Good luck ,
I hope it helps
It is good that someone is using manganese for a change.
DENIED,
Just do the testing and stop guessing. There is a program that I suggested which contains everything that you mentioned for POIS. And some people are on it and feeling better, but for everybody there is their own program., since POIS is not the same thing for everyone. Estrogen dominance is not the only your reason .
POIS is too much or too low acetylcholine.. High thyroid high dopamine high progesterone low acetylcholine, low thyroid low dopamine low progesterone high acetylcholine.