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New Theories / Re: Post Orgasmic Illness Syndrome (POIS)
« on: 04/06/2013 16:16:19 »I know, but I am in remission, zero diarrhea and little pain, that is, until I ejaculate. POIS triggers the diarrhea.
More likely some consequence of orgasm triggers your IBD ... http://en.wikipedia.org/wiki/Occam%27s_razor
I just found out that that pharmacological agonists of 5-hydroxytryptamine2A (5-HT2A)serotonin receptors can block the pro-inflammatory effects of Tumor Necrosis Factor (TNF) on smooth muscle vascular cells.5-HT2A receptor is involved in cognition. TNF is supposed to promote inflammatory reactions in Crohns disease. This is interesting because serotonin appears to be pro-inflammatory, as a number of studies have shown depletion of serotonin within the CNS acts to reduce animal models of inflammation such as adjuvant-induced arthritis. However it suppresses multiple responses to TNF. Testing to find TNF active have failed, but I never had orgasms before testing. My Crohn diagnostic is not 100% accurate because of lack of acces to the small intestine, and gluten free diet helped me more than drugs, but any complex protein is not recommended for any IBD because it can cause issues on a damaged intestinal lining. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861806/
Another indicator of low serotonin is that orgasms make me VERY hungry, serotonin activates some neurons and melanocortin-4 receptors, or MC4Rs, to curb appetite and at the same time blocks other neurons that normally act to increase appetite. High Acetylcholine seems like the path I should take , it is a serotonin antagonist, in a damaged intestine, I suppose Acetylcholine binds to receptors in the intestine and induces that dreaded diarrhea, causes brain fog, joint pain, etc. The problem I face are the high costs of testing anything were I live.