[Arthur]

Arthur asked the Naked Scientists:

Love your show. I'd like to ask what is an itch and what causes it.

Arthur in Jersey
(the USA kind)

What do you think?

[Karen W.]

I am no expert but would hazard to guess that perhaps drying skin that is shedding is a top reason for some itching.. others may be allergic reactions to foods chemicals that cause irritations on our skin.. eczema type conditions etc.. Some people have a nervous habit of scratching etc... I also itch when I am overly warm.. which brings on more a heat rash...
Overall I believe that shedding of our drying dying outer layer of skin probably is just a normal itch.. sunburns and drying skin feel the same itchiness as the skin peels away.. which I see as the shrinking of that skin and I think it is that shrinkage we feel as an itch as it actually dries causing the itch..just guesses as I say.. perhaps someone in dermatology field could shed some skin light on this!

[paul.fr]

Scientists find why scratching relieves an itch
Nerves transmit signal to the brain in monkeys; may aid in new treatments

updated 10:43 a.m. ET April 6, 2009

NEW YORK - Scratch an itch and you get ... aaaaaah. Now scientists have watched spinal nerves transmit that relief signal to the brain in monkeys, a possible step toward finding new treatments for persistent itching in people.

More than 50 conditions can cause serious itching, including AIDS, Hodgkin's disease and the side effects of chronic pain treatment, said Glenn J. Giesler, Jr., a neuroscientist at the University of Minnesota in Minneapolis. Some terminal cancer patients even cut back on pain medication just to reduce the itch, he said.

Scratching can lead to serious skin damage and infections in people with chronic itch, he said. So scientists want to find ways for such people to relieve their distress "without tearing up their skin," he said.

While medications can relieve some kinds of itch, other cases resist current treatments.

Nobody knows just how scratching relieves itch. But the federally funded monkey study, reported Monday on the Web site of the journal Nature Neuroscience by Giesler and colleagues, takes a step in unraveling the mystery.

The scientists focused on a kind of spinal nerve that transmits the "itch" signal to the brain. These nerves reach into the brain from near the bottom of the rib cage.

The researchers sedated long-tailed macaques for the experiment and placed recording electrodes on their spinal nerves. They injected a chemical into the skin of a leg to produce itching. The nerves fired electrical signals in response.

Then the researchers scratched the leg with a hand-held metal device that simulates three monkey fingers. The firing rate dropped — the apparent signature of the "relief" signal.

In contrast, when researchers scratched the leg without causing an itch first, the firing rate jumped. So the nerves somehow "know" to react much differently if there's an itch to be relieved than if there isn't.

"It's like there's a little brain" in the spinal cord, Giesler said. "We really want to understand that, because then we think we'll understand how to relieve itch."

Maybe scientists can identify signals that tell these nerves to provide the relief response, and then try to mimic that action with drugs or some kind of stimulator, he said.

Dr. Gil Yosipovitch of the Wake Forest University Baptist Medical Center in Winston-Salem, N.C., who didn't participate in the study, said in an e-mail that his own work shows that particular brain circuits also play a role in how scratching quells itch.

He called the new study "very important" and said it opens further research on the nervous system and itching.

http://www.msnbc.msn.com/id/30069529/

[Karen W.]

Cool Post Paul.. That is very interesting.. I assume the monkeys were alright...

Information is really good.

They should have asked me to be the guinea pig! I itch constantly... but I have learned to cope with it!

[Chemistry4me]

Remember this thread?

[Karen W.]

Yep I do remember.. LOL