[Dor Ant (OP)]

I recently moved my attention to the GnRH pulsatility and still cannot make a clear picture in my mind about the basis of this pulsatility. Could anibody explain to me what are the newest clues about this internal clock. Also for the dual effect of E2 on GnRH pulse, is it mostly due to affection of GnRH-receptors or somehow directly on GnRH production by the GnRH neurons. Thanks!


_{Mod edit - formatted the subject as a question.  Please try to do this to help keep the forum tidy and easy to navigate - thanks!}