[Starsky]

Ok, i couldnt sleep all night because I have a theory
In my opinion the main problem is histamine, we are realising too much of it while ejaculation. The problem is free histamine will try to bind to receptors: H1, H2, H3, H4. Thats why we have so many pseudoallergy rections to dust etc. Histamine receptors are in brain too so we will get some cognitive problems. A cure for pois would be blocking the release of histamine, i think the best way desensitization, but i think TRT therapy, niacin, XN are working because they are somehow blocking the release of histamine. Fenugreek, ranitidine and others are just partially a cure because they are blocking the receptors so we could get less symptoms but the problem will be still there. Guys what do you think about that?

Has someone an idea what happens with histamine in REM phase in sleep? I think when i sleep longer i will have more aches.

Something about Relora:

The complete mechanism of action for Relora® is unknown.
However, there is a significant body of research on some of
the compounds in this product that is consistent with Next Pharmaceutical’s research and the indications for which Relora®
has demonstrated significant benefit. As with most natural products that are rich with more than one active compound, it is likely that these benefits may be due to more than a simple additive effect
from the compounds that have been studied. The following is a discussion of the known pharmacological properties of Relora®. Clinical studies in China and Japan suggest that the oriental herbal medicine saiboku-to relieves anxiety-related disorders such as anxiety neurosis.2,6 It has been demonstrated that the anxiolytic effect of saiboku-to is due to the presence of the two key compounds in Relora® – magnolol and honokiol.7 These compounds have also been shown to have an inhibitory effect on histamine release from rat mast cells.8 Benzodiazepines, including diazepam, bind to GABAA receptors. Diazepam enhances the anxiolytic effect of saiboku-to (due to magnolol and honokiol) and flumazenil, a GABAA antagonist diminishes this anxiolytic effect.9
This suggests that the compounds in Relora® might exert their anxiolytic effect by acting as GABAA receptor agonists. More recent research shows that the compounds in Relora® act by a different mechanism, possibly via an indirect cholinergic activity such as inhibition of histaminergic neurons linked to cholinergic neurons.8

Niacin helps reaching orgasm

Niacin (also known as vitamin B3) is important for the manufacture of the sex and adrenal hormones; however, along with its primary prosexual effects, shortly after ingestion, niacin can produce sensations of intense warmth accompanied by a tingly itch throughout the body lasting up to 20 minutes. It may also produce a reddish cast to the skin, which is especially pronounced in the extremities. This response is called the “Niacin Flush.”
A thoroughbred stallion that was unable to reach orgasm. When the animal was given niacin, the stallion was quickly restored to full form.

This red, itching warmth caused by niacin use is well known and is harmless. The flush is healthy and indicates that niacin is helping improve blood flow and circulation. Reaction from the Niacin Flush actually mimics an individual’s natural sexual response. This natural sex flush, which has been documented by Masters and Johnson, is caused by a large histamine release; in fact, a niacin flush is caused by the same histamine release as the natural sex flush, with one important difference: Because niacin instigates a larger-than-normal histamine release, the results of using niacin are often more dramatic.

While the large organs of the body all have blood supplied from large arteries, a great deal of the human body, particularly the parts near the skin, get their only supply of blood from small capillaries. Niacin causes these small capillaries to expand, allowing them the ability to possibly carry 2 or 3 blood cells at the same time. This is a tremendous increase in blood flow.
Niacin’s Orgasmic Benefits

Niacin may also be helpful for individuals experiencing difficulty achieving orgasm. The ability to experience an orgasm is related to adequate histamine release, which is an essential factor in the male orgasmic experience. Researchers Pearson and Shaw give a fascinating account of a thoroughbred stallion that was unable to reach orgasm. When the animal was given niacin, the stallion was quickly restored to full form.

[Starsky]

 
Stop histamine release naturally

Releif from rhinitis, hay fever, asthma, hives and more...

Stop histamine release naturally

By: Dr Parham Donyai LL.B(Hons), Dip. LP, MCSR, ITEC

 

What is a histamine problem?

Are you one of the millions of people suffering from excess or unnecessary release of histamine? Do you even know what this is?

If you have any sort of allergy, you are in the above group. In fact, you may be in the group even if you don't know it. If you have eczema, rhinitis (constant runny nose), hay fever, asthma, hives, nasal congestion, itchy eyes, skin eruptions and many other problems, your body may be releasing excess histamine.

Excess release of histamine is a nightmare. In different people, it causes different problems. The release of histamine can be triggered by certain agents such as dust, pollen, foods or environments.

Traditionally, there is very little you can do but to take an anti-histamine. Sounds easy, right? Yes apart from the fact that many anti-histamines can give quite bad side effects such as drowsiness or blurred vision. They are not a "cure" to the problem and merely just "mask" the symptoms.


What causes excess histamine release?

Excess histamine is caused by different things in different people. Sometimes it is easy to pinpoint the cause and many times it is almost impossible such as in hives (urticaria).

House dust mite, pollen, traffic pollution, wheat, dairy products, heat or perfumes can all cause histamine release. This is not an exhaustive list and there are many other things that can cause your body to release extra histamine. The result (which you can see or feel) can be anything from sneezing, runny nose, red eyes to a skin outbreak.

A toxic body is much more likely to be prone to excess histamine release than a healthy non toxic one. For example, if you eat too much rubbish (cakes, cookies, sweets, artificial foods, fatty foods, alcohol) or too much red meat (as an example) your body will be busy trying to digest and detoxify, thereby exhausting its resources and not being able to deal with other things (pollen for example).

Toxicity exhausts the adrenals and your adrenals are one of the main glands of your body and an important one in fighting "inflammatory" problems, such as histamine release.


Here's how to beat stop histamine release naturally...

It is very possible for you to change the way you live and eat slightly better to have a body more geared up to stopping histamine release.

Imagine, no more blocked or runny nose; no more hives breakouts just when you don't need it.

You need to stick to the advice below and not stray. The release of histamine can be triggered by the slightest stimuli. Stick to the advice below for at least 3 months to give your body a chance to recover and rest. You will see results way before that.

* First things first. Cut down protein intake, especially animal proteins. Try and cut it to around 10% of your daily calorie intake. Excess protein is a drain on your body's resources. You need to cut it down so your body starts resting and not be in a constant over-active state.
* Try and cut out all dairy, wheat and gluten products. Most stores these days sell dairy free and gluten free products. Dairy, wheat and gluten can contribute HUGELY to histamine release.
*  First thing upon waking up, drink a full glass of clean water with some lime or lemon juice squeezed in. This is great for a gentle liver cleanse.
*  Drink lots of water at regular intervals during the day. Your body releases histamine in order to stop water loss. If you give your body adequate amounts of water, less histamine will be released. This is very important. Many people who suffer from histamine problems are not drinking enough water.
* Cut out ALL artificial sweeteners. This means those found in diet drinks, many foods (low fat/no fat) and chewing gums.
* There is no doubt that an organic vegetarian diet is very good for those who have a histamine problem. A diet high in Quercetin and  flavonoids such as citrus fruits, berries, onions, parsley, legumes, green tea, and red wine is especially good.
* Omega-3 fatty acids, found in fish, flax, hemp, borage and evening primrose oils are especially good as they decrease inflammation.
* A diet high in garlic and onion is very beneficial also (please say sorry to your partners!)
*  Foods high in vitamin C and Bromelain are very good. Vitamin C is a natural anti-histamine. Eat oranges, tangerines, fruit juices and pineapple.

Monitor your body. Buy a diary and mark in there when you get an attack. You will soon see a pattern and will be able to find out the offending foods/environments/triggers. You can then try and eliminate them.


…and here's an instant remedy to stop histamine release fast

You didn't think I would leave you without some form of "instant help", did you?
Go to your local health shop and get yourself some tablets of:
*  Quercetin (take say 1000 mg a day)
*  Bromelain (500mg a day)
* Nettle extract (500mg a day)
*  Vitamin C (1000 mg a day)

This may all sound difficult to get but don't worry help is at hand. Help comes from food supplements companies that have already thought about this and have started manufacturing all in one tablets with the above.

Start taking the combination pill above and change your diet and you WILL see great results in just days.

If you have any allergy experiences which you wish to share, you can email in to this site.

Good luck!

[demografx]

Research Fund Total: $2,485.00


Please read about it at:
http://poiscenter.com/forums/index.php?PHPSESSID=97a0a767229bfcd7b6822ec05c6c0160&topic=125.0

Then help yourself! by donating here:
http://www.rarediseases.org/about/support/research-donations/fg_base_view_p3


Thank you very, very much, everyone!!

Ooops, did you just hear it go DINNNGGGG!


Now it's Research Fund Total: $2,585.00

[Green]

^^

The figure is actually higher

[demografx]

Green, because of the wonderful pledges?

[demografx]

"Your Semen Could Be Your Worst Enemy"  [] (now I've heard it all!)  []
http://tribune.com.ng/index.php/your-health/25050-your-semen-could-be-your-worst-enemy

[demografx]

POIS Donor Database System (PDDS)

You may have just noticed an email appeal in your inbox from us.

This is the culmination - AND beginning - of a database marketing system that has been months in the making, and has finally been LAUNCHED!

The database includes 326 known POIS sufferers, going back as far as 2007, to the beginnings of this forum. But it also includes survey respondents from Counterpoints' research survey, and members from the other forum at www.POISCenter.com .

Apart from my modest contribution, let's all give a big, warm congratulations to The PDDS Team:

daveman

Martin88

rock27

nordnurse (a/k/a Stefanie from NORD)

This is a major event for us, as we now have a database system in place as sophisticated as any MAJOR fundraiser I've ever worked with, such as Amnesty International, CARE, and March of DIMES.

This is an ongoing effort and will include donor campaigns, newsletters, and much more, so stay tuned!

[demografx]

Research Fund Total: $2,685.00


Please read about it at:
http://poiscenter.com/forums/index.php?PHPSESSID=97a0a767229bfcd7b6822ec05c6c0160&topic=125.0

Then help yourself! by donating here:
http://www.rarediseases.org/about/support/research-donations/fg_base_view_p3


Thank you very, very much, everyone!!

[Stef]

Hello All,

There is one note of major clarification needed regarding the post by Demografx about the email appeal.

Demo wrote, "Apart from my modest contribution, let's all give a big, warm congratulations to The PDDS Team..."

FYI, there was nothing MODEST about Demo's contibution. not even slightly modest about his contribution.  He was full steam ahead on this -- totally involved and a major driving force!

That's Demografx -- never wishing to take the limelight and always boosting up the others.

We won't let him get away with it!!! []

[Starsky]

Another part of my histamine theory which corelates with Demografx case:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665824/

[Habibou]

I think every potential cure as a huge link with histamine release as a neurotransmitter anyways. Testosterone, Vitamine PP (niacin B3), diet, sunlight...I guess Now we have to find which one is the most efficient to balance it.

[demografx]

Habibou, very interesting, until your post directly above mine here, I didn't see the connection between the various treatment theories and histamine release > neurotransmitter performance.

Thank you for the concise explanation!

[demografx]

Hello All,

There is one note of major clarification needed regarding the post by Demografx about the email appeal.

Demo wrote, "Apart from my modest contribution, let's all give a big, warm congratulations to The PDDS Team..."

FYI, there was nothing MODEST about Demo's contibution. not even slightly modest about his contribution.  He was full steam ahead on this -- totally involved and a major driving force!

That's Demografx -- never wishing to take the limelight and always boosting up the others.

We won't let him get away with it!!! []

<blushing>            Thank you, Stefanie!

[Habibou]

You are welcome demo !  []
Histamine are 2 things  =  neurotransmitters (for the brain cells) / the histamine stocked in every other cells of the body which detects the allergen.

The release implies (among many others)=
 
- important release of adrenaline/noradrenaline (mine were very high 2 hours after the O)
- tachycardia
- the contraction of respiratory ducts (which could explain the narrow throat, the lack of   oxygen into the cells which could create muscle pain (myalgia)but also lack of oxygen in the brain cells which could create brain fog if it lasts too long time.
- the contraction of digestive ducts (which could explain the diarrhoea)and nausea, gastric reflux, belly pain.

Perhaps, the "allergic reaction due to the fact the semen stays inside the body implies a release (during a long time) of histamine, which implies the disorders above" but also "the long lasting release of noradrenaline (which is the case in my blood tests) which creates a mental exhaustion in the first place (same as brain fog).

The semen stays inside the body could explain the long lasting release of histamine (which creates a lack of it after some time) explains why a simple "antihistamine" isn't enough. This creates a neurotransmitters disorder (unbalance) and the cognitive symptoms so.
This matches and seems clear with my own case!

Histamine is linked with many others neurotransmitters,

[victor.kons]

You are welcome demo !  []
Histamine are 2 things  =  neurotransmitters (for the brain cells) / the histamine stocked in every other cells of the body which detects the allergen.

The release implies (among many others)=
 
- important release of adrenaline/noradrenaline (mine were very high 2 hours after the O)
- tachycardia
- the contraction of respiratory ducts (which could explain the narrow throat, the lack of   oxygen into the cells which could create muscle pain (myalgia)but also lack of oxygen in the brain cells which could create brain fog if it lasts too long time.
- the contraction of digestive ducts (which could explain the diarrhoea)and nausea, gastric reflux, belly pain.

Perhaps, the "allergic reaction due to the fact the semen stays inside the body implies a release (during a long time) of histamine, which implies the disorders above" but also "the long lasting release of noradrenaline (which is the case in my blood tests) which creates a mental exhaustion in the first place (same as brain fog).

The semen stays inside the body could explain the long lasting release of histamine (which creates a lack of it after some time) explains why a simple "antihistamine" isn't enough. This creates a neurotransmitters disorder (unbalance) and the cognitive symptoms so.
This matches and seems clear with my own case!

Histamine is linked with many others neurotransmitters,

Wow, thank you Habibou, this idea looks very very truthful to me. This hypothesis explains everything, every my symptom.
If everything is correct then it is really the big dose of Nicotine acid that helps me when I inject XN. And when I will try to do injection of Nictotine acid tomorrow I should have the same relief as with XN.

If you contemplate doing something like this, please consult a qualified medical professional before attempting this on yourself!

Victor

[Habibou]

Thank you Victor! I just try to understand...
Look the additional consequences of histamine in the body : (from a french website + google translation)

-increases the power and frequency of the heartbeat (for the release of adrenaline)
-contributes to the onset of vomiting
-regulates the sleep-wake
-cuts appetite
-helps regulate body temperature, blood pressure and pain sensation
-contributes to the production of gastric acid and the functioning of the gastrointestinal  tract
-regulates the hormonal balance
-is a brain neurotransmitter

Also, I found the "histamine intolerance" on this website which appears mainly after :

-physical effort (i get that)
-sudden emotional stress (i get that)
-hormonal fluctuations (my comment :Orgasms make an hormonal fluctuation): Women often develop allergic reactions before the start of menstruation
-Infectious Diseases
-certain medications

High level histamine foods :

-alcoholic beverages (especially red wine, certain types of beer, sake) (my comment:could explain we feel very bad after little alcohol !, we perhaps have normal bad alcohol feeling + histamine intolerance
-Junkfood
-cheese (long uncured)
-sausage: sausage raw, salami, sausage
-meat: pork liver and beef (very high), Parma ham, gendarmes, Bündnerfleisch, bacon (histamine increases with maturation)
-coffee

How does the doctor he diagnosed an intolerance to histamine?
 The collection of detailed medical history (history) is the first step. The physician can help a diary kept by the patient about his diet and its disorders (where when? How?).
 
 In most cases, the doctor recommends an elimination diet(could explain why some arrives to lowerate POIS symptoms by diet?). This is for the patient to follow a diet low in histamine for about four weeks. In people with an intolerance to histamine proven, improvement of symptoms is so rapid. For a definitive diagnosis, the doctor performs a controlled oral challenge test.
 
 The following laboratory tests are performed in the diagnosis of histamine intolerance:

 measuring the level of vitamin B6
 measuring the activity of diaminoxydase
 histamine release test (stimulation test)
 measuring the level of histamine in the blood

The administration of vitamin C and vitamin B6 supplements appear to improve symptoms.
 Cromoglicic acid decreases the rate of histamine in the body and slows the release of histamine.

Last thing : The risk is particularly high in people suffering from inflammatory bowel disease or food allergy cross. Very few people suffer from a congenital deficiency of the enzyme.
 
 An excess of histamine can be caused by foods that are themselves rich in histamine or the "histamine release" that induce secretion of histamine by body cells. This results in allergic disorders. (personal case : I have many food intolerances)
sorry for the long post ! []

[demografx]

Habibou, very interesting, until your post directly above mine here, I didn't see the connection between the various treatment theories and histamine release > neurotransmitter performance.

Thank you for the concise explanation!

Thanks for expanding on the topic!

[Habibou]

I would have felt guilty if i kept it for myself  [] ...!

[Starsky]

Found on the internet:

Your ability to orgasm (in both men and women) is GREATLY influenced by your body's "blood histamine level"? Oh and by the way...the release of histamine into the blood is also what happens when your body responds to some kind of allergen. SNEEZING therefore can be a bodily response to histamine being released in the body!

I use to share in my college Human Sexuality classes this interesting sexual tidbit from the book Nutrition and Vitamin Therapy written by Dr. Michael Lesser M.D. the father of Orthomolecular Medicine.

"In a study of 28 men, Dr. Carl Pfeiffer found the men's speed of ejaculation was correlated with their blood histamine; the HIGHER the HISTAMINE level the QUICKER the EJACULATION. MEN TOO LOW IN HISTAMINE however cannot attain ejaculation...though erection is no problem."

Similarly, A WOMAN LOW IN HISTAMINE may be UNABLE to achieve orgasm and may be considered frigid. Conversely, men who ejaculate prematurely AND women capable of repeated or sustained orgasm MAY have elevated blood histamine levels!

FYI: Cells containing histamine are concentrated in the head [glans] of the p e n i s. One would infer there is also a concentration of cells containing histamine in the c l i t o r i s since the c l i t o r i s sexually...is the female version of a penis that has been testosterone deprived.

A premature male ejaculator may want to consider taking calcium and the amino acid methionine which lowers histamine...an hour prior to intercourse...or they could take an over the counter ANTI-histamine which also lowers histamine but has some side effects (ie: drowsiness) that calcium and methionine don't have.

An aside thought here: Ladies if you have noticed your ability to orgasm during allergy season becomes more difficult...the cause MAY be the over-the-c0unter antihistamines you take to stop your allergic reactions to allergens. One lady I dated...realized after I told her the need for histamine in order to orgasm...the reason why she could not orgasm during allergy season. The anti-histamines she was taking for her allergies were blocking her ability to orgasm...by blocking her body's histamine release!

Females who are not reaching orgasm due to insufficient histamine levels might want to consider taking the B-vitamins folic acid and niacin which elevate histamine. Make sure you take NIACIN and NOT THE NON-FLUSH niacin cousin "niacinamide" since you will not evoke a histamine release from niacinamide.

For those adventurous souls seeking a NEW and UNIQUE sexual experience...try taking 250-500 MG of niacin a half hour before becoming sexually active. Almost anyone taking a strong dose of NIACIN for the first time will respond with a "VERY STRONG" histamine release that usually includes hot itchy sensations in "various parts" of the body. The histamine flushing will eventually wear off in an hour or so but the hot itchy sensations you experience during the flushing COULD add something "sexually hot" to your lovemaking experience.

There are times when I sneeze while I am in the process of being turned on...however I am a discriminating sneezer in the sense that not just any type of sexual behavior or sex talk evokes a sneeze. Only "certain behaviors" or "certain words" spoken in a "specific context" that evoke "specific ideas" are capable of evoking a sneeze from me.

[jivetalk]

Okay Guys, so here is the first Niacin Pills Report:

I have been taking Niacin (Niacinic Acid) Pills 100mg twice a day since Monday. First time O was last night, but I took 300 mg of Niacin prior to O to ensure that I got the Niacin Flush.

So How am I feeling today?

Well...I feel that my POIS day 1 isn't as bad as it normally is, but its no where near 100% gone either, I would say POIS intensity is 60-70%. However it is very hard to say if this was due to Niacin, it could be a placebo effect, or it could be just the POIS itself. Sometimes my POIS intensity isn't as bad as other times, it just depends on the day.

I am finding that taking niacin is increasing my blood flow, I think I can feel it. The Flush that I get from Niacin isn't really that strong either, it is more of just a mild tingling sensation.

I will just have to keep experimenting. Am very interested in the results of Victor's injectible Niacin Experiment, and any one else's experiences with Niacin. I don't think anyone else has reported back on Niacin as yet...