The Naked Scientists
  • Login
  • Register
  • Podcasts
      • The Naked Scientists
      • eLife
      • Naked Genetics
      • Naked Astronomy
      • In short
      • Naked Neuroscience
      • Ask! The Naked Scientists
      • Question of the Week
      • Archive
      • Video
      • SUBSCRIBE to our Podcasts
  • Articles
      • Science News
      • Features
      • Interviews
      • Answers to Science Questions
  • Get Naked
      • Donate
      • Do an Experiment
      • Science Forum
      • Ask a Question
  • About
      • Meet the team
      • Our Sponsors
      • Site Map
      • Contact us

User menu

  • Login
  • Register
  • Home
  • Help
  • Search
  • Tags
  • Recent Topics
  • Login
  • Register
  1. Naked Science Forum
  2. Life Sciences
  3. Physiology & Medicine
  4. COVID-19
  5. Are vaccine trials logging t-cell immunity?
« previous next »
  • Print
Pages: [1]   Go Down

Are vaccine trials logging t-cell immunity?

  • 1 Replies
  • 1899 Views
  • 0 Tags

0 Members and 1 Guest are viewing this topic.

Offline set fair (OP)

  • Sr. Member
  • ****
  • 467
  • Activity:
    0.5%
  • Thanked: 19 times
  • Naked Science Forum Newbie
Are vaccine trials logging t-cell immunity?
« on: 02/10/2020 21:53:20 »
We read about vaccines resulting in x% of trial particpants producing antibodies. What about specific T cells?
Logged
 



Offline evan_au

  • Global Moderator
  • Naked Science Forum GOD!
  • ********
  • 11033
  • Activity:
    8%
  • Thanked: 1486 times
Re: Are vaccine trials logging t-cell immunity?
« Reply #1 on: 14/10/2020 09:21:09 »
It's not easy to count the number of T-Cells which react to SARS-CoV2 (or any other specific target).

Your body has many different strains of T-cells, each targeting a different pathogen to which you have been exposed in th epast (or against which you have been vaccinated). Sometimes different strains of T-cells could be targeting different aspects of the same pathogen. There could be hundreds or even thousands of T-Cell strains.

The challenge here is to identify and count the individual T-cells which respond to the coronavirus (out of many T-Cells in a blood sample). This is not easy, as they T-Cells must interact with other cell types (eg dendritic cells) to activate the T-Cells.
- This T-Cell selection process is not easy - just look at the prices being charged for monoclonal antibody treatments

While some of these T-Cells circulate in the bloodstream (and are thus easy to collect), other T-Cells hide in lymph nodes or in particular tissues, and so can only be collected by a biopsy (much more intrusive).

See: https://en.wikipedia.org/wiki/T_cell#Cytotoxic_CD8+_T_cells
Logged
 



  • Print
Pages: [1]   Go Up
« previous next »
Tags:
 
There was an error while thanking
Thanking...
  • SMF 2.0.15 | SMF © 2017, Simple Machines
    Privacy Policy
    SMFAds for Free Forums
  • Naked Science Forum ©

Page created in 0.448 seconds with 33 queries.

  • Podcasts
  • Articles
  • Get Naked
  • About
  • Contact us
  • Advertise
  • Privacy Policy
  • Subscribe to newsletter
  • We love feedback

Follow us

cambridge_logo_footer.png

©The Naked Scientists® 2000–2017 | The Naked Scientists® and Naked Science® are registered trademarks created by Dr Chris Smith. Information presented on this website is the opinion of the individual contributors and does not reflect the general views of the administrators, editors, moderators, sponsors, Cambridge University or the public at large.