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If the seeds had no nutritional value the plant wouldn't need to protect them with poison.
However grape seeds are packed with high level of antioxidants, or OPC (Oligomeric proanthocyanidins ), which can bring down the level of blood pressure, protecting cell from free radicals and many more. But I just couldn't find information on guava seeds which can be comparable to grape seeds. 
In one small study, individuals taking both vitamin C and grape seed extract experienced increased blood pressure. While the increases were not dramatic, individuals with high blood pressure may want to check blood pressure more often if both grape seed extract and vitamin C are taken together. If blood pressure rises, either vitamin C or grape seed extract or both may need to be stopped.
Grape seed extract may possibly increase the time blood needs to clot.