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yep - tht'as my info!And it is only at the 4th and 5th didit.But SOMEWHERE I read about those silicone injections, which basically prevent further growth of the tissue and later state of contracture, and the clawlike deformity!No info on that, "thedoc"I am definitely in the "beginning" state and would like to just not GET to the "claws"!(Probably would preventing me from riding my mororcycle and I REALLY had to commit suicide!!!)How about this:"It has been proved that in laboratory cultures the 5-FU barely reduces collagen reduction in <b>normal</b> fibroblasts, but produces a drastic reduction in the <b>altered fibroblasts</b>, as happens in <u>Dupuytren's disease</u>, acting on the gene controlling the amount of protein or the messenger. It also seems to counteract the capacity of growth factor TGF-1 to stimulate collagen production"More???Sandy in Montana