How do nucleic acid polymerases distinguish between different bases?

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Offline NaCl

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So I understand that DNA polymerase has a small binding pocket helps it distinguish dNTP and riboNTP. What mechanism does the RNA polymerase use to distinguish riboNTP and dNTP, U and T? Any papers I can refer to?

« Last Edit: 24/11/2009 20:39:47 by chris »


Offline Nizzle

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I think the best thing to do is go to a second hand book store and buy a molecular biology handbook.

Here's a hint: It's not a mechanism that distinguishes U and T, it's morphology. And the morphology of a protein is influenced by... [;)]
« Last Edit: 17/11/2009 14:47:14 by Nizzle »
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