Adenosine Deaminase

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Offline Donnah

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Adenosine Deaminase
« on: 14/09/2003 21:10:22 »
Can someone tell me about adenosine deaminase?  What is it what does it do, interactions, sources...that sort of thing.
« Last Edit: 31/05/2004 05:34:03 by NakedScientist »
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Offline Ians Daddy

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Re: Adenosine Deaminase
« Reply #1 on: 14/09/2003 23:23:40 »
Donnah,
I didn't read it in it's entirety, but it sounds serious. You don't know anyone with iot do you?

http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997%20Case%20Studies/CMarting.html

Hope that helps.
 

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Offline Donnah

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Re: Adenosine Deaminase
« Reply #2 on: 15/09/2003 02:50:30 »
No, just doing research...seems to be a key factor in failing immune systems.  T-cells initiate an immune response and are produced in bone marrow.  Bone marrow transplants seem to "fix" ADA (adenosine deaminase) deficiency to some degree but I haven't yet grasped the connection between T-cells and ADA.
« Last Edit: 15/09/2003 02:59:55 by Donnah »
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Offline bezoar

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Re: Adenosine Deaminase
« Reply #3 on: 15/09/2003 04:49:37 »
From what I gather from the article, The lack of ADA causes an increase in other chemicals which are toxic to the lypmphocytes or white blood cells.  Additionally, there is a breakdown in making and repairing DNA.  What is interesting is that I read they are trying to infuse ADA combined with PEG.  I saw tht they are trying this with interferon for treatment for hepatitis as well.  PEG, if I'm not mistaken, is antifreeze.  Somehow I think it results in higher levels of whatever chemical you combine it with and slower excretion.  All this stuff is way over my head.  We need the doctor!