Does Caffeine Decrease Neuroprotection/neurogenesis?

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Offline davekm

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Caffeine increases BDNF, and prevents stress induced decreases in BDNF.

However, chronic BDNF downregulates the TrkB receptor. - http://www.ncbi.nlm.nih.gov/pubmed/8752592

This is true of caffeine as well. -http://www.ncbi.nlm.nih.gov/pubmed/22841916

Does downregulation of TrkB stops BDNF from performing it's functions, like neuroprotection and neurogenesis?