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You would have to say that statistically, flying is a lot safer than driving, for long journeys (and bus is very good, too).See: http://en.wikipedia.org/wiki/Aviation_safety#Statistics [nofollow]
It has recently been suggested that global warming will lead to atmospheric changes that will increase the amount of clear air turbulence at the level at which most jets cruise. This will potentially increase fuel costs, increase inspection and maintenance costs, and shorten anticipated plane lifetimes; this, in turn, will cause ticket prices to rise.
... Worst case scenario, you can take sedatives to reduce your anxiety or to sleep through the flight.