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Endocannabinoid mediated signaling may facilitate endogenous remyelination. Hence, intracellular THC delivery can probably affect MS pathogenesis.
... MS is rare in the equatorial regions ...
Orkney islands have highest rate of multiple sclerosis in the world – studyOne in every 170 women in the islands has the degenerative neurological disease – and the incidence rate is rising
Readers should bear in mind that remyelination does occur, to some degree, without treatment. Some people with MS experience astonishing near-complete spontaneous-recoveries because of natural remyelination.
... can endocannabinoid mediated signaling affect endogenous remyelination...
Based on previous laboratory studies suggesting that certain types of cannabinoids may protect the nervous system, Dr. John Zajicek (Plymouth University Peninsula Schools of Medicine and Dentistry) and colleagues in the United Kingdom conducted a three-year clinical trial (CUPID) to test whether dronabinol (a synthetic Cannabis/marijuana derivative) slows progression in people with primary-progressive or secondary-progressive MS. The results of the trial, published in 2013 in Lancet Neurology showed that dronabinoal was unable to demonstrate a positive effect on disease progression.
Before discussing the subject any further, can you you provide any actual hard evidence that MS sufferers who use cannabis have slower progression of the disease ?.