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LD50is the way that pharmacologists measure lethality. It's the amount of a toxin that must be given in order to cause death in 50% of the animals it was given to. Tetrodotoxin, botulinum toxin and ricin all have LD50values around 1 ng/kg (depending on exact form of the toxin, route of adminstration and species). Tetrodotoxin is associated with Fugu poisoning (Fugu is pufferfish sushi) and zombies. See the movie and/or book called the Serpent and the Rainbow for a popular treatment of the story, or Wade Davis's books & article for more serious information. Botulinum toxin is found in improperly made or sealed canned goods. Ricin is man-made. And I'd like to take a moment to point out that I am a neuropharmacologist, not a bad sushi chef, homecanner or terrorist.
also, there are various radioactive "poisons" that cause death over a few days and require just a few molecules to be in the body, they were used to kill that one russian guy not to long ago.
In that case (Polonium 210) the radioactivity is in the form of alpha particles (helium nuclei) which are stopped completely from a fraction of millimeter of matter. Inside a human body, however, alpha particles react with some organic substances forming very toxic compounds.
you would think that being buried 6 feet under ground would provide adequate insulation.... isnt it like 3 feet of earth or 10 feet of water is enough to protect you from the radiation of a nuclear bomb?