[hurray]

Thank you also to jivetalk, silverandcol and Guthrie! Initial reports seem very promising indeed - I wish I could test niacin for myself, but it's not too easy to buy in my current location ...

All the reports so far seem positive with regards to reducing/eliminating POIS symptoms - perhaps we are on the verge of a breakthrough here  []

[demografx]

Very exciting developments!

Everyone reading this: please also heed victor.kons' cautionary remarks on the previous page.

Experiment with competent medical supervision only!

[demografx]

Thank you also to jivetalk, silverandcol and Guthrie! Initial reports seem very promising indeed - I wish I could test niacin for myself, but it's not too easy to buy in my current location ...

All the reports so far seem positive with regards to reducing/eliminating POIS symptoms - perhaps we are on the verge of a breakthrough here  []

On this first phase, if we have good success, (let's say 50% of us have 80% relief, or some similar indicator) we should look into why and how it is working. Because one thing is "breakthrough" in finding symptom relief, and another is "breakthrough" as in cure!

Only by identifying the whys and wherefors can we identify what type of breakthrough it is.

If it's not a cure, then, at some point in time it will come out and bite us. Perhaps continual use of XN / Niacin will damage our livers or we may drop investigation and research and find that it isn;t a cure or that it wears off with time or whatever.

So, yes, optimistic and enthiused, anxious, but extremely cautious.

Thanks everybody for the good and responsible (for the most part) testing!

EDIT: I accidentally deleted from iPhone so I reposted - demo

[Habibou]

Interesting things about Histamine on Wikipedia :

H3 histamine receptor = Found on central nervous system and to a lesser extent peripheral nervous system tissue    Decreased neurotransmitter release: histamine, acetylcholine, norepinephrine, serotonin.

Suppressive effects

While histamine has stimulatory effects upon neurons, it also has suppressive ones that protect against the susceptibility to convulsion, drug sensitization, denervation supersensitivity, ischemic lesions and stress.[9] It has also been suggested that histamine controls the mechanisms by which memories and learning are forgotten.

I personally take an H1 antihistamine which does not make anything on me, I should perhaps care of the H3 which has an important link with the brain ( memory/learning = cognitive)

[B_Daniel]

French doctor David Servan-Schreiber is dead today. He was fighting a brain cancer. He was was a defender of nutrition as additional therapy. On a video he gave me the solution of the effect of sugar and high glycemic index food on inflammation that I consider as the best explanation for my Pois improvement since 2008.

That's unfortunate.  I have always known that when I eat a large unhealthy meal, or even something as simple as drink a soda with high fructose corn syrup, my brain fog becomes "horrifically" severe for 30mins - 3 hours.  Not like a big meal sleepiness, but like my brain just stops functioning at all.  Sometimes a stimulant like coffee can help reduce how bad it gets during those periods.  B_Jim, if you have more info on the inflammation link, I'd love to read it. 

This "inflammation" is another large puzzle piece that we need to ultimately hand over to our NORD selected researcher to aid him/her in understanding WHAT pois is and HOW is manifests its symptoms.   

[B_Daniel]

...I'll try B3 100mg this week.

Hey namesake! - I have so far bought nicotinamide ("niacinamide") and also Inositol Hexanicotinate - which are both niacin variations that do not provide the flush.  The right stuff to get is niacin (also known as vitamin B3, nicotinic acid and vitamin PP).  You likely already know this, just wanted to make doubly sure that no one else does what I did!

[demografx]

...I'll try B3 100mg this week.

Hey namesake!

 [] [] []

[hurray]

On this first phase, if we have good success, (let's say 50% of us have 80% relief, or some similar indicator) we should look into why and how it is working. Because one thing is "breakthrough" in finding symptom relief, and another is "breakthrough" as in cure!

The early indications are that Dr Waldinger was right on the money - his method of treating an allergic reaction to semen is textbook medical science:

http://en.wikipedia.org/wiki/Allergen_immunotherapy

My uninformed guess would be that the niacin is depleting the body's supply of histamine, so that the POIS allergic reaction ends up being far less severe. I'm not knowledgable enough to understand the exact mechanism by which niacin might prevent POIS, but the link between histamines and allergic reactions is very strong - it seems very likely that niacin's interaction with histamines is the key to why niacin "works".

I don't think that niacin will end up being regarded as a cure, but it could well turn out to be the best short-term solution for dealing with day-to-day POIS. If it can work long-term without causing liver damage (as determined by regular blood tests), then it would be pretty amazing.

Dr Waldinger's semen desensitisation may well be the long-term cure, but only time can tell how effective it will be years from now. In the meantime, if niacin holds up, it could be the closest we have come so far to ridding ourselves of POIS.

[demografx]

We started a POIS Research Fund to boost our final and fatal attack on The POIS Monster! Explained here:
http://poiscenter.com/forums/index.php?topic=125.0


We raised $2,150 in just the first 2 weeks, with much more pledged!


But we need $33,500. Please give today so we can get rid of POIS once and for all!
Go to the POIS Fund donation site and Let's Make It Happen, Everybody!
http://rarediseases.org/about/support/research-donations

[jivetalk]

Niacin Pills Report #4:

Okay Guys for this little experiment, I tried to do something which would normally have had me in VERY VERY POIS, cowering in a corner somewhere, shutting myself away from the world - completely unmotivated, lethargic, full of brain Fog and likely depressed. I have tried to O twice in two days - both times using Niacin (Nicotinic Acid Pills).

Monday Night:
Dosage: 3 x 100mg Nicotinic Acid Pills about 40 Minutes prior to O.

Straight after O, absoloutely no Brain Fog which is my main symptom straight after O. Was able to sleep fine - It seems that the Niacin Side Effects that I initially had are starting to wear off.

Tuesday Morning:
Woke up the next morning, was again absolutely amazed that I was NOT lethargic, and had Zero Brain Fog. It really is a DIFFERENT feeling waking up the next morning - expecting POIS but having NONE. Throughout the day, I maybe had 5-10% of Brain Fog - but it's hard to tell if this was due to brain fog or something else/stress/headache etc...

Tuesday Night:
Dosage: 3 x 100mg Nicotinic Acid Pills about 40 Minutes prior to O.

Same Scenario as previous night - No problems sleeping or overheating at all.

Wednesday Morning:
I woke up this morning, really really expecting POIS - some of Lethargy or brain fog at least. To my great suprise I had absotley NOTHING. It is currently about 3.21pm here - and I have had absolutely Zero symptoms all Day. I feel absolutely fantastic today - This is probably a combination of it being a Sunny day here AND the fact I have no POIS today, and are very excited by this little experiment.


Notes:
- I am VERY VERY excited by this test, I wanted to do something that would have for SURE put me in POIS previously.
- I did this test to prove to myself that this is NOT a PLACEBO effect.
- I made SURE that I took the Pills at least 30 mins Prior to O, and that I felt the FLUSH effect completely - and let it pass before O. I feel this is a critical component.
- I think that if you do not do the above, the damage would have already been done if you O - and these pills would only have little effect (although they still will have some).
- I will try to reduce my dosage soon, but at this stage am reluctant, as I am getting such good results.
- Please Keep posting our Results - GOOD or BAD.


If you will now excuse me, I am going to make some 'I LOVE B3' Tshirts to wear around. I think some of you here also made some promises about putting up posters of a certain Guy and his CAT  []

[victor.kons]

EXCELLENT results, thank you SO MUCH, I'm very glad for you jivetalk!

Victor

[horizon]

Yesterday took 2 x 500mg Niacin (on day 2) at 10pm.
Woke up at 3am with bad sunburn type effect, skin pain. Then woke in morning 7am feeling like I had 2/3 beers the night before.
Its not for me,
its the harshest food supplement ever. I think even smaller doses will be bad for my liver over time.

Pills, sunburn, hangover...like a night out in Ibiza without the fun.

[victor.kons]

Yesterday took 2 x 500mg Niacin (on day 2) at 10pm.
Woke up at 3am with bad sunburn type effect, skin pain. Then woke in morning 7am feeling like I had 2/3 beers the night before.

Sounds like a VERY BIG dose. I had feeling like that even from 100mg niacin acid tablet. You had dose 10 times bigger than me.

Thats why I like injections of XN, because I need pretty small dose and have no reaction neither from liver nor from stomach.

Its not for me,
its the harshest food supplement ever. I think even smaller doses will be bad for my liver over time.

Pills, sunburn, hangover...like a night out in Ibiza without the fun.

Not for me either, not a long time solution. XN injections is a long time solution for me.

Warning! Don't try self-injections without consulting from your doctor, you might cause permanent injury to yourself.

Victor

[horizon]

Sounds like a VERY BIG dose. I had feeling like that even from 100mg niacin acid tablet. You had dose 10 times bigger than me.

lol, yeah i was abit complacent because it was only food supplement.

[jivetalk]

Sounds like a VERY BIG dose. I had feeling like that even from 100mg niacin acid tablet. You had dose 10 times bigger than me.

lol, yeah i was abit complacent because it was only food supplement.

Hahaha...Horizon. I would encourage you to try a smaller dose - BEFORE Orgasm. Please do not dismiss Niacin because I feel you have not given it a fair chance.
Please consult with your doctor too though.

I feel that taking Niacin AFTER the event will do very little. I think Victor will also attest to that.

I think if you O without Niacin, DAMAGE is done. Therefore Taking Niacin afterwards will do little. By Taking Niacin prior - It somehow PREVENTS Damage, which means you do not get affected by POIS or at least get affected a lot less.

Note:  Please also ensure that it is Nicotinic Acid you are Taking - Also NOT Slow Release.

[jivetalk]

EXCELLENT results, thank you SO MUCH, I'm very glad for you jivetalk!

Victor

Thank YOU Victor. I must say, if it wasn't for you who came onto these forums and encouraged us to look at Niacin and Niacin Derivatives like XN - I would not have found this solution. So Thank YOU Victor - Very Very Much.

[victor.kons]

Sounds like a VERY BIG dose. I had feeling like that even from 100mg niacin acid tablet. You had dose 10 times bigger than me.

lol, yeah i was abit complacent because it was only food supplement.

Hahaha...Horizon. I would encourage you to try a smaller dose - BEFORE Orgasm. Please do not dismiss Niacin because I feel you have not given it a fair chance.
Please consult with your doctor too though.

I feel that taking Niacin AFTER the event will do very little. I think Victor will also attest to that.

I think if you O without Niacin, DAMAGE is done. Therefore Taking Niacin afterwards will do little. By Taking Niacin prior - It somehow PREVENTS Damage, which means you do not get affected by POIS or at least get affected a lot less.

Yes, I completely agree with Jivetalk, - taking Niacin afterwards is doing little. Niacin should be taken prior to orgasm to prevent POIS symptoms.

Victor

[Habibou]

Here is the pharmacokinetics of an oral pill and the optimal effect in the body :
(it can fluctuate, regarding the pills, but this is an average) Our next step is to know it for the Niacin/XN. If someone has it already?  []

[Starsky]

Victor.cons Do you know some russian trusted online pharmacies?

[victor.kons]

Victor.cons Do you know some russian trusted online pharmacies?

Sorry, I don't know such pharmacies.

Victor