[B_Daniel]

....Meanwhile, elevated testosterone can suppress oxytocin and vasopressin..."

As Demo showed before, the testosterone patches speed up his recovery, this might of had something to do with it's relationship to oxytocin and vasopressin.

Hey Scott, thanks for posting!  So testosterone and oxytocin ARE correlated.  However, if testosterone (good at reducing POIS) goes up when oxytocin goes down (bad for us), then it appears as if their relationship is the INVERSE of what we'd expect to see.

I found over a period of time researching oxytocin, prolactin, dopamine, and serotonin, that although they share a strong relationship with our symptoms, they just can't be at the core of our problems.  There are just too many discrepancies that I found.  Like, for instance, caffeine makes me feel better on POIS days.  But caffeine raises prolactin levels, not reduces them.  One other big tell all for me is that I've tried every anti-depressant out there.  The anti-depressants specifically adjust my dopamine and serotonin levels - But that didn't make me feel any better... although garlic did.  I know garlic didn't just boost my serotonin more dramatically then ________ (fill in anti-depressant name here). 

I don't know.  Those are my thoughts on that.  Not to say I couldn't be completely wrong though.

And about the hypoglycemic stuff, I wouldn't doubt AT ALL that the pois gives me low blood sugar.  There is definitely a relationship btwn the two.  Just look at B_Jim's healthy diet - it's a diet that prevents hypoglycemia (i believe), and it dually helps reduce his pois symptoms.  Once again though, that might be a component of our symptoms, but i just have trouble believing that that could be a root cause of it all.  Because if that were the case then a sandwich and a nap would cure me  []

[demografx]

IF YOU DID NOT RECEIVE THIS IN YOUR EMAIL RECENTLY, KINDLY LET ME OR DAVEMAN KNOW. THANX!!

[EDS]

I tried the Niacin test before my most recent "O".
I have to say that it seems to help! I is not 100%, but I would rate it at around 50%... possibly more.
I took 250mg 1 hr before "O" and about 1 hr after a large evening meal. I did not feel the "flush" so I did not know if it would help and was wondering if I had the right form of Niacin. I could not find a bottle that listed Nicotinic Acid - only Niacin as the active ingredient. But the label did have the "flush" warning so I assumed it was the right stuff.

I got up the next morning and felt okay (although my worst day is usually day 2) and ate a small breakfast (cereal). Soon after eating I took another 250mg tablet. Nothing happened for about an hour so I thought for sure I had the wrong form of Niacin. Then it hit... hard. The "flush" was very intense, starting at the top of my head and working down to my toes. This is not a good feeling! My skin turned very red and my blood pressure went up - not to a dangerous level, but elevated above my normal BP for morning. I had to get in the pool to help offset the intense heat for about 20 minutes. It took about an hour for the symptoms to subside. I know the hot flush is suppose to be normal, but it was not a good experience  [!] (this is about the color I was too).

The great news is... I had one of the best second and third days from "O" than I've had in a long time  []. I understand that the "flush" is less intense each time you take Niacin. I don't fully understand why it did not "flush" the first time, unless it was the large meal prior, which caused a very slow ingestion rate of the Niacin.

So do we really have to feel the flush or does it still help if you take it after a large meal? Or, is the one in the am where I felt the intense flush the one that helped the most? More experimentation  []. 

At any rate, I will definitely try Niacin the next time and hope for the same good results and less burning.

Keep up the good work all and let's get OUR NORD fund FULLY funded!!!!

[daveman]

From what we've been learning, it seems the flush is helpful, if not required. And I was JUST reading on Niacin, they recommend taking it on a full stomach to reduce the effect of the flush.

The flush doesn't need to be as strong as it was with your second dose. If you can try a lower dose, maybe half, it would be a good starting point, and take it before food intake.

Victor indicates that the flush should be present and then just pass before the "O".

[daveman]

For those who did not receive the last newsletter, you can read it at http://poiscenter.com/newsletters/NL-2.htm

I will be posting them there as they also go out by mail. this way if we find anything of value that we can pass on to others, they will be available on the WEB.

[Laura_L]

I'm a journalist interested in doing a story on POIS for a major men's magazine. For it, I'm looking for a few men who would be willing to go on the record and talk about their experience with the disease. (You can remain anonymous, if you'd like.) If you're interested in being interviewed or have questions about the story, please email me at laura.leu@gmail.com

[apostate801]

Is Niacin to be taken only when you know you'll orgasm?  If you're already POISed, will taking it alleviate the symptoms?  If you take it regularly and O 6 hours after your last dosage will that help? 

[jivetalk]

Is Niacin to be taken only when you know you'll orgasm?  If you're already POISed, will taking it alleviate the symptoms?  If you take it regularly and O 6 hours after your last dosage will that help? 

Is Niacin to be taken only when you know you'll orgasm?  If you're already POISed, will taking it alleviate the symptoms?  If you take it regularly and O 6 hours after your last dosage will that help? 

Hi Apostate,

These are some very good questions. From my experience taking Niacin whilst in POIS does little to alleviate symptoms. As far as taking it regularly, I don't think this will help - All this seems to do is increase your resistance to Niacin making it harder to get a 'flush' when you need it.

The way to use Niacin that seems most effective is to take a dosage of Niacin (I have been taking 300mg) about 45 minutes-60minutes prior to orgasm. You should feel a 'Flush' and let it pass before you O. The Amount of time before the flush, and duration Flush seems to vary depending on how much food is in your stomach.

We are very much in the early stages of testing Niacin, but my results and some others on here have been very promising. Please remember to talk to your health professional before taking Niacin - Yes it is readily available and just a Vitamin Supplement but it can interfere with other medicines and can damage the liver.

If you do try Niacin - Please post your results here, Good or Bad - This will certainly contribute to this groups further understanding.

JT.

[jivetalk]

I tried the Niacin test before my most recent "O".
I have to say that it seems to help! I is not 100%, but I would rate it at around 50%... possibly more.
I took 250mg 1 hr before "O" and about 1 hr after a large evening meal. I did not feel the "flush" so I did not know if it would help and was wondering if I had the right form of Niacin. I could not find a bottle that listed Nicotinic Acid - only Niacin as the active ingredient. But the label did have the "flush" warning so I assumed it was the right stuff.

I got up the next morning and felt okay (although my worst day is usually day 2) and ate a small breakfast (cereal). Soon after eating I took another 250mg tablet. Nothing happened for about an hour so I thought for sure I had the wrong form of Niacin. Then it hit... hard. The "flush" was very intense, starting at the top of my head and working down to my toes. This is not a good feeling! My skin turned very red and my blood pressure went up - not to a dangerous level, but elevated above my normal BP for morning. I had to get in the pool to help offset the intense heat for about 20 minutes. It took about an hour for the symptoms to subside. I know the hot flush is suppose to be normal, but it was not a good experience  [!] (this is about the color I was too).

The great news is... I had one of the best second and third days from "O" than I've had in a long time  []. I understand that the "flush" is less intense each time you take Niacin. I don't fully understand why it did not "flush" the first time, unless it was the large meal prior, which caused a very slow ingestion rate of the Niacin.

So do we really have to feel the flush or does it still help if you take it after a large meal? Or, is the one in the am where I felt the intense flush the one that helped the most? More experimentation  []. 

At any rate, I will definitely try Niacin the next time and hope for the same good results and less burning.

Keep up the good work all and let's get OUR NORD fund FULLY funded!!!!

Thanks for the Report EDS. Great to hear you got some reasonable results first try around. In my experiments I think I seem to get better results based on 'timing', I need to make sure I've had the flush (even if it is minor) before O. But you are right - If I've had a big dinner or something I get very very minor flush or sometimes even none at all.....I just wait about 60 minutes, and by then its usually okay.

Please keep letting us know how you go.

JT

[daveman]

Is Niacin to be taken only when you know you'll orgasm?  If you're already POISed, will taking it alleviate the symptoms?  If you take it regularly and O 6 hours after your last dosage will that help? 

Apostate801,

There's lot's of information on our other forum of the Niacin experiments at:
http://poiscenter.com/forums/index.php?topic=174.0

Basically it is best taken about an hour before "O". A dosages of somewhere around 150 to 300 mg (experiment beforehand with the smaller dose to see how you react to the flush).
Taken after the "O", has much less effect.
Taking it regularly seems to reduce the effectivity, as it seems to desensitize rather than strengthen the effect.

[daveman]

FYI

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[victor.kons]

Hi All,

I continue experiments with Niacin Acid tablets. Seems the effect is stable for me, e.g. no POIS symptoms if tablets are taken 1 hour before "O" in dosage of 150 mg. I've tried this trick 3 times so far, and every time - no POIS.

Warning! Taking Niacin in high doses might cause damage to your liver, please consult with your doctor first

Victor

[demografx]

FYI

 [ Invalid Attachment ]

"Is it my breath???"

[demografx]

C'mon...someone give $5...it'll still be progress!
http://www.rarediseases.org/about/support/research-donations/fg_base_view_p3

[demografx]

I'm a journalist interested in doing a story on
POIS for a major men's magazine. For it, I'm looking for a few men who would be willing to go on the record and talk about their experience with the disease. (You can remain anonymous, if you'd like.) If you're interested in being interviewed or have questions about the story, please email me at laura.leu@gmail.com

Thank you, Laura, and welcome to The POIS Forums!

[ophicus1213]

I have been taking Niacin for over a year now and have been benefiting greatly from it.  I have extended into the higher doses above three grams per day.  If anyone is interested I would suggest looking into a disorder called B3 dependency.  I will be attaching some quality articles I have found about the potential for Niacin to be used in clinical settings to treat anxiety. 

http://www.orthomolecular.org/library/jom/2004/pdf/2004-v19n02-p104.pdf [nofollow]

http://orthomolecular.org/library/jom/2005/pdf/2005-v20n03-p167.pdf [nofollow]

[demografx]

ophicus1213, thank you very much for your encouraging reporting!

demo

[victor.kons]

I have been taking Niacin for over a year now and have been benefiting greatly from it.  I have extended into the higher doses above three grams per day.  If anyone is interested I would suggest looking into a disorder called B3 dependency.  I will be attaching some quality articles I have found about the potential for Niacin to be used in clinical settings to treat anxiety. 

http://www.orthomolecular.org/library/jom/2004/pdf/2004-v19n02-p104.pdf

http://orthomolecular.org/library/jom/2005/pdf/2005-v20n03-p167.pdf

Thank you ophicus1213, the papers are very interesting.

Btw, I noticed that jumping to high doses of Niacin Acid from the start is not good and it can cause negative response from liver and heart. But if you continue smoothly increasing dose, the body somehow adapts to it and there is no any discomfort even from the doses that caused terrible effects at the start.

Victor

[demografx]

Just posted at Men's Health UK
(posted by MHUK forum member "poisissue")

Subject: Post Orgasmic Illness Syndrome

I have been suffering from this condition for a few years now.

The conditions symptons first start after an orgasm from having sex or masturbation. The symptons that last for 1-2 days (in my case) will usually include, lack of concentration/focus (Brain Fog),lethargy, headache, mylagia (muscle pain/weakness), anxiety, irratability, low ebb, etc.
Just thought i'd put it out on here to see if there are any other unfortunate sufferers on here and to make aware that i recently typed this problem into a search engine online, found a forum for it, and was surprised how many other victims there were of this rubbish condition. Because there has so far not been a great deal of awareness or publicity aimed at this condition, only very limited research has been made into it, which in turn has not led to validated treatment medication.
Guys on the forum i found, were trying out different types of medicines, practices pre and post orgasm to try and find a cure. Basically experimenting stuff for themselves, then posting their results. It would be good if anyone on here could give any results of their own experiences etc, or guys out there who thought they were the only ones with this condition can be made aware that they are far from alone.


I hope this can lead to better things and appreciate all comments (Good of course, not crass) put forward.

And just to inform all that the symptons i have are post having sex with my FEMALE partner, and that i am besides this condition, a generally fit healthy guy, with a normal stable mind, as are most of the other peeps on the forum i have been on.......

[daveman]

I have been taking Niacin for over a year now and have been benefiting greatly from it.  I have extended into the higher doses above three grams per day.  If anyone is interested I would suggest looking into a disorder called B3 dependency.  I will be attaching some quality articles I have found about the potential for Niacin to be used in clinical settings to treat anxiety. 

http://www.orthomolecular.org/library/jom/2004/pdf/2004-v19n02-p104.pdf

http://orthomolecular.org/library/jom/2005/pdf/2005-v20n03-p167.pdf

Thank you ophicus1213, the papers are very interesting.

Btw, I noticed that jumping to high doses of Niacin Acid from the start is not good and it can cause negative response from liver and heart. But if you continue smoothly increasing dose, the body somehow adapts to it and there is no any discomfort even from the doses that caused terrible effects at the start.

Victor

If it can work at 150-300 mg just before orgasm, why would you take it daily to raise the threshold and dose to such high values?

Taking it less often (as little as possible) avoids raising the dose to such levels.