[Animus]

My mother made a donation of 200$ and my father one of 300$ for a total of 500$ for NORD research 
Message for everypeople willing to donate : benefit from the SPONSOR so that we convert our pledges into real research and the 33.500 $ is reached this month !

this is so nice Habibou. many thanks!

[CertainlyPOIS]

To all of you out here - I am speechless...and in shock.

For over 10 years I have been trying to find OTHERS who are having the same "issues" I have been having immediately after ejaculation...that then last for up to 3 days....usually 2.5 days (two full nights of sleep) on average before I can safely re-emerge to society.  I just 10 minutes ago, through a fluke, came upon this site: https://sites.google.com/site/poiswebsite/home AND FREAKED OUT.

I am a POIS sufferer (there's a name for it!) and have been looking for others for years....I am in shock - sorry if I may babble a bit here.  Here is the letter I just wrote to Dr. Waldinger:

----
Dear Doctor Waldinger,
All I CAN SAY IS O MY GOD …..for over 10 years I have been suffering from POIS…at times frantically trying to find others on the internet who have this issue – to no avail.  I am 37, male, 135lbs over all generally healthy.

I have never met ANYONE else who has this issue…and then…right now….2 minutes ago I came upon the Google POIS site which led me to you.  I am so incredibly happy I can't put effective words to it.

For years I have described what is happening to just a few of my closest friends and all of them are like I have never ever heard of that and know of no one else who does.  It appears though I AM NOT ALONE!!!! 

I have this infliction.  After orgasm…I AM EXTREMELY irritable and despicably tense (including muscle tension curling) and it lasts usually 2.5 days almost to a T.   I usually try to immediately go to sleep as I am convinced it has to do with my pituitary and that something in me needs to reset – the faster I am to sleep and in REM sleep creating GH the better.  I am terrified of any non-sexual intercourse ejaculation because of this – though I have found if I am having sex with a women…(no condom) I believe potentially this BALANCES me somehow lessening the effects due to her chemical interactions – though this maybe just in my mind - but that has tended to be the case.

I have taken GABA for years immediately after ejaculation and this often lessens the effects and am terrified of unintended masturbatory/dream related ejaculation due to all of this.

TO say I am flabbergasted to have found this site and community is an understatement.

That I have a community I can talk with about this makes me happy.

Please send me any questionnaire you need.
----END OF EMAIL----

Continuing on...I have found GABA works very very well for me in SPEEDING up my recovery time and I swear by it.  5-HTP also helps but not as much as GABA - I have taken 5-HTP for over 20 year for sleep - but GABA soothes my intense crankiness - if I take enough GABA I can often bounce back incredibly fast sometimes allowing me to get through the day without intense flashes anger/anxiety/tension.  FYI...I switched from GABA to PICAMILON about 1 year ago (Picamilon is GABA bonded with NIACIN) and I believe the Picamalon is effectively allot better than GABA alone as it does not make you sleepy like GABA alone does.  I am convinced this inflection has to do with my pituitary and related nervous system as deep sleep seems to be the only thing that allows me to fully restore myself...but at least two sleep cycles of such is required...making me think the large GH pulse you get from REM sleep helps to restore the balance. 

Note I have symptoms that are EXACTLY POIS...I could jump through hoops right now. I try my hardest to not go to any social function after as I have no ability to socialize normally.  I try to avoid all people for 2 to 3 days... ...friends who have known me for years will be like..."why are you so irritated"....and I have never had the gall to tell them cuz they would not understand...this has gone on for so many years now many know me to be moody....when I know its actually cause of what has been going on!!!!!

I would love to Skype with anyone who also has this just to talk to someone else.....who can be like..."..ya dude...i know what ur talking about..."

I am in shock....I am not alone.........

 is nice you have finally found this website.  You are among people that understand how you feel.   
As of late we have transition to our own website called poiscenter.com, it is also a forum. Come over there and register with the name you are using for this site. There, the conversation is still going and you can find out about other methods people are using to alleviate their symptoms.   One of those methods involve flush niacin which pretty much cures some 100%, you will be interested in that thread.
It is no surprise you just found this site eventhough it is almost five years old. It took months of searching the internet to find it.

welcome again.

[Copperred]

Dear All,
To say the least I am relieved I am not the only person on earth with this issue - for a while I truly believed this was the case.

I find it rather stunning/serendipitous having been 10+ years in the woods alone - I too stumbled upon niacin-related treatment on my own - HOWEVER I stumbled into niacin AS A RESULT OF GABA in the form of PICAMILON. GABA has always been at the center of my POIS treatment and niacin second - and when the two are bonded (as they are in Picamilon) you get a very special effect you will not get on either of them alone.

Deeper explanation:

My primary treatment for POIS has for years been to take GABA immediately after O - usually 1000 to 2000mg.  I have been doing this for years and it helps allot (100% recovery much faster than without), however, GABA alone will make you sleepy/drowsy immediately and I quickly go take a nap - which I believe the immediate REM sleep and related natural growth-hormone (GH) pulse that follows likely plays a supportive role in helping "reset" my system.  Due to a close friend in the neurological sciences, however, I learned about Picamilon and immediately switched over to it about 2 years ago upon finding the results much better without the immediate need for sleep caused by GABA alone.

Picamilon, as a substance, is focused on the GABA...not on the niacin. The niacin has been bonded to the GABA to act as a DELIVERY MECHANISM for the GABA....assisting the GABA cross the blood brain barrier faster and in a more concentrated form. Taking the two substances separately is NOT the same thing. Picamilon is about getting GABA to the brain - not about taking niacin.

Wikipedia entry on Picamilon: newbielink:http://en.wikipedia.org/wiki/Picamilon [nonactive]

Info on Picamilon:  newbielink:http://www.calmclinic.com/anxiety/drugs/picamilon [nonactive]

To purchase high-grade Picamilon: newbielink:http://www.biologicsnutra.com/productdetails.asp?productid=460 [nonactive]

Enhancing Orgasm with GABA:

Orgasm release is controlled by the body?s levels of gamma-aminobutyric acid (GABA). GABA (synthesized from glutamine and inositol) is considered to be one of the most important inhibitory neurotransmitters in the central nervous system. GABA helps inhibit excitatory neurotransmitters that can cause anxiety if the system is overstimulated. This is important, since chronic anxiety can lead to loss of sexual interest and sexual dysfunction.

GABA is responsible for regulating sexual tone and plays an important role in brain hypothalamic/pituitary function.21 Therapeutic drugs that increase the available amount of GABA typically have relaxing, anti-anxiety, and mood-soothing effects.22 Conversely, when GABA becomes depleted, it is difficult to relax and let go of fear and negative feelings. Hence, orgasm becomes difficult. GABA-enhancing compounds could help increase dopamine levels, which may enhance sexual satisfaction.

-----

I hope this is of help to some of you.  I have never tried niacin alone - but may just as a comparative test and report back here.  On the whole I will continue to stick with Picamilon (and GABA alone when Picamilon is not available) as it has been working for me for years without fail.

Again really glad to know I am not alone!

Cheers! 

[POIS-SUFFERER]

Picamilon, does this create a flush.... I really hate the Niacin flush!

Thanks!

[Copperred]

I have never experienced a flush...but it may well still create one if taken in high enough dosages.  I usually take 100 to 200mg of Picamilon immediately after O and then every 4 to 6 hours until I am safely out of the woods.

It may well create a flush if taken at much higher dosages...but I have never experienced one.

[mat780]

Copperred, WELCOME!!!

I'm the webmaster of the site you found us in first, so I'm happy twice   

Please, take a look at the New POIS Forum, where you can find the most up to date data and discussions:
http://www.poiscenter.com/forums/index.php [nofollow]

Please, introduce yourself there too, so the rest of us know about your case.

You can also take a look at our POIS YouTube Channel, where you can find at least two documentaries, where POIS is mentioned. One is from The Learning Channel and the other from ABC Australia.
http://www.youtube.com/user/POISchannel [nofollow]

Kind Regards,
Mat

[observercenter]

Hi folks,

I'm speaking here as a moderator.  We do appreciate the good this thread has done for those suffering with POIS and the value of this forum for collecting and sharing information about POIS. 

However, we do not currently allow users to engage in fund raising via the forum.  Posts soliciting donations on this forum will be removed.  I know that poiscenter.com does allow donations, and you are free to refer members to that site so long as you are not asking for donations your referral post. 

Thank you for your understanding,
JP moderator

Thank you for your reminder JP, Habibou and me were only trying to catch everyone attention. Regards.

[Over it]

Hello,

I have been taking Lovan for about 12 weeks. That didn't help during POIS at all but did a little outside of POIS. I have been taking Doxycycline (an antibiotic) for 3 days and my POIS has decreased by 95%. I have had about 10 blood tests over the last 10 years and nothing abnormal was ever detected.

[Starsky]

Doxycycline has strong antiinflammatory properties/

[B_Daniel]

Hello,

I have been taking Doxycycline (an antibiotic) for 3 days and my POIS has decreased by 95%.

Hey Over It, can you keep us posted on the doxycycline, please?  You've only been at it for 3 days, which isn't a long enough test period to draw any conclusions, but it is a promising sign that it's working so far.

I've been trying to really focus on my POIS symptoms lately to try to connect some of the dots.  While I don't have much/any acne, one thing I've noticed is that my face is always more oily on days with POIS.  Doxycycline reduces acne, so is there a link here??  If there is it seems to be a stretch.

Another thing POIS reminds me of is that hangover feeling a few hours after smoking pot.  Anyone know chemically what the link could be between pois and smoking mj? (From all the posts of Kurtosis I've read, I know his answer to this will be definitely be acetaldehyde poisoning... which I suspect is the case here!)

[Omen 30]

Even I have noticed a better feeling with antibiotics,less brain fog.I think the good and bad bacterias in our gut are killed and because of that I get a clearer thinking,I am even having yoghurt on regular basis so that the ratio of good bacteria remains healthy in the gut

[kurtosis]

Hello,

I have been taking Doxycycline (an antibiotic) for 3 days and my POIS has decreased by 95%.

Hey Over It, can you keep us posted on the doxycycline, please?  You've only been at it for 3 days, which isn't a long enough test period to draw any conclusions, but it is a promising sign that it's working so far.

I've been trying to really focus on my POIS symptoms lately to try to connect some of the dots.  While I don't have much/any acne, one thing I've noticed is that my face is always more oily on days with POIS.  Doxycycline reduces acne, so is there a link here??  If there is it seems to be a stretch.

Another thing POIS reminds me of is that hangover feeling a few hours after smoking pot.  Anyone know chemically what the link could be between pois and smoking mj? (From all the posts of Kurtosis I've read, I know his answer to this will be definitely be acetaldehyde poisoning... which I suspect is the case here!)

Not just acetaldehyde, histamine. You're introducing a allergen into a body that may have too high histamine. It just makes it worse that it increases acetaldehyde load as your body tries to get rid of it. (as does histamine and some other neurotransmitters).

We can't get rid of acetaldehyde from our bodies and we can't avoid all allergens. All we can do is try to help our body reduce the levels of both histamine and acetaldehyde over time.

So increasing methylation and cellular ATP (see discussion on poiscenter, it would take me hours to describe it all here) seem a better idea than these elimination diets which are impossible to stick to. Actually I think most elimination diets are given to people who are simply overproducing histamine and they're misguided in that the foods ruled out often contain vital nutrients.

[B_Daniel]

I've been doing some research on mj this morning.  I can't find much information on histamine releases with use although I don't doubt that it's a factor.  Even in regards to the red eyes, supposedly that's not cause by histamines but by blood vessels dilating due to increased pressure and decreased bloodflow.  There's a lot more talk about weed's affect on cholinergic transmissions i.e. choline & acetylcholine.

"Choline is the precursor molecule for the neurotransmitter acetylcholine which is involved in many functions including memory and muscle control."  THC's effects on acetylcholine as a neural correlate of reduced cognitive function involve its regional effects on cholinergic transmission in brain regions relevant to learning, memory, etc. Weed has a way of dampening choline all over the place, resulting (at least partly) in the cognitive impairment following acute and chronic use."

I don't really know how this is relevant, but thought I'd throw it out there.

[Mer]

Please watch this TED Talk : The Great Porn Experiment: Gary Wilson at TEDxGlasgow

[kurtosis]

I've been doing some research on mj this morning.  I can't find much information on histamine releases with use although I don't doubt that it's a factor.  Even in regards to the red eyes, supposedly that's not cause by histamines but by blood vessels dilating due to increased pressure and decreased bloodflow.  There's a lot more talk about weed's affect on cholinergic transmissions i.e. choline & acetylcholine.

"Choline is the precursor molecule for the neurotransmitter acetylcholine which is involved in many functions including memory and muscle control."  THC's effects on acetylcholine as a neural correlate of reduced cognitive function involve its regional effects on cholinergic transmission in brain regions relevant to learning, memory, etc. Weed has a way of dampening choline all over the place, resulting (at least partly) in the cognitive impairment following acute and chronic use."

I don't really know how this is relevant, but thought I'd throw it out there.

Not the cannabis in particular, just smoking produces an allergic response.
If someone has high histamine levels then they're more likely to have some respiratory allergies. Smoking is one of the things which further increases histamine levels and leads to allergic response.
See paper at http://www.jacionline.org/article/S0091-6749(06)00942-0/abstract

[questforlife]

Ok, so this might sound a bit random.  But can someone give this is a go.  Its perfectly safe.
Buy some DMSO cream (its very cheap and perfectly safe for delivering nutrients through the skin)
Apply to the inside of the arm - i do mine in the middle on the other side of the elbow.
Take a capsule of amino acids supplement (find one that cover most of the amino acid range - i use kirkman Amino Support)
Apply the powder on top of the DMSO cream on your arm
Apply more DMSo on top and rub into the skin.

It can be a bit messy.  But if anyone is willing to try this please let me know how you get on.  Perhaps do this at the height of your POIS symptoms.  If this helps you i can explain my theory.  Ps sorry kurtosis for taking you off topic from above.

[Starsky]

DMSO without any adds doesnt work?

[kurtosis]

Ok, so this might sound a bit random.  But can someone give this is a go.  Its perfectly safe.
Buy some DMSO cream (its very cheap and perfectly safe for delivering nutrients through the skin)
Apply to the inside of the arm - i do mine in the middle on the other side of the elbow.
Take a capsule of amino acids supplement (find one that cover most of the amino acid range - i use kirkman Amino Support)
Apply the powder on top of the DMSO cream on your arm
Apply more DMSo on top and rub into the skin.

It can be a bit messy.  But if anyone is willing to try this please let me know how you get on.  Perhaps do this at the height of your POIS symptoms.  If this helps you i can explain my theory.  Ps sorry kurtosis for taking you off topic from above.

Nah, that's cool.
I've used MSM as well as methionine by itself. MSM is similar to DMSO.
http://en.wikipedia.org/wiki/Methylsulfonylmethane

There's a big discussion on histamine and methylation over on poiscenter.com.
The discussion is about whether POIS may have aspects of mitochondria dysfunction (including extreme fatigue) and high histamine producing persistent and chronic inflammation.

I find the ability of methionine (and other methyl group providers) to help overcome POIS depends on how energetic I feel. I think this is because the body requires a methionine source and ATP (a byproduct of glycosis) to make SAMe. But yeah, in principle DMSO might reduce inflammation and lessen POIS symptoms by helping to reduce histamine levels, among other things. 

I've now switched to SAMe as it gives results faster and I'm taking it every day rather than just O days.

For best effect, take some b vitamins, especially b3 (niacin/niacinamide) and b6 as these are crucial in the 2nd stage of a lot of methylation reactions including for neurotransmitters like histamine, dopamine etc.

[nathan123]

Hi,

My Testerone results came and it is normal..  And presently I am taking herbal life and POIS is not occuring.  But I came to know that Herbal life which is very rich in protein is dangerous for Liver and Kidney if taken for long time.  Hence as per suggestion of my doctor I required to stop Herbal life diet from tomorrow onwards.  Don't know hos POIS will behave from next orgasm. 

Pl guide whether high protein intake is harm for kidney and liver. 

[questforlife]

Hi Kurtosis, the theory is based around using DMSO as a method of transporting nutrients through the skin.  In my experience it can work as well as IV and there is alot of medical trails documented  on the web that confirm this.  I personally think amino acid deficiency play a huge role in the issues we are facing.  Why that deficiency occurs in the first place is another matter.  But I was interested to know if any one could try this transdermal method of Amino acid supplementation to see if it provides relief to POIS symptoms.  It helps me quite significantly and if it helps others then there could be something there worth delving deeper into.  So I guess its just an experiment if anyone if willing to try.  Its safe and relatively inexpensive.