[GoingCrazy]

When it comes down to it, that's what I believe my POIS is.  A combination of histamine, prostaglandins and Leukotrienes working on my brain in response to orgasm.  That's probably why antihistamines make me feel better, but not 100% because there is still prostaglandins and leukotrienes that cause a reaction.  The only bad thing about taking medication to help it is they are used by your body in other processes, unrelated to POIS, and also used in the brain for other purposes.  We need to do some more research on these things. I'd like to find possible medication for all or seperate medications for each.

The only thing that confuses me is after I've been celibate for a while I kind of get irritable, but that can be due to lack of release correct?

And also, I'd like to comment on a possible remedy during POIS.  It is one a day vitacraves gummies + immunity support.  One possible reason it helps is because of its selenium content.  It definitely puts me into a better mood.

[kurtosis]

When it comes down to it, that's what I believe my POIS is.  A combination of histamine, prostaglandins and Leukotrienes working on my brain in response to orgasm.  That's probably why antihistamines make me feel better, but not 100% because there is still prostaglandins and leukotrienes that cause a reaction.  The only bad thing about taking medication to help it is they are used by your body in other processes, unrelated to POIS, and also used in the brain for other purposes.  We need to do some more research on these things. I'd like to find possible medication for all or seperate medications for each.

The only thing that confuses me is after I've been celibate for a while I kind of get irritable, but that can be due to lack of release correct?

And also, I'd like to comment on a possible remedy during POIS.  It is one a day vitacraves gummies + immunity support.  One possible reason it helps is because of its selenium content.  It definitely puts me into a better mood.

I'm getting the genetic testing done. I have to know for definite which genes are mutated so I can come up with a methylation treatment that works with me. There's so much stuff to factor in. COMT, HNMT, MTHFR, MTR, BHMT, DAO etc. I don't think there are silver bullets but I do believe that something like ketitofen may help. Prostaglandin and histamine are released from mast cells so a mast cell stabiliser seems a good starting point for any treatment.

It all depends whether the POIS is caused by an inability to restore homeostasis after an O which may be obvious from looking at genes controlling deactivation of histamine via methylation (for instance) OR whether we simply have too many mast cells (some form of mastocytosis). I don't know but I want to know as much about my own DNA to help answer the question!

Clarityn D worked for my worst POIS and I believe it's the combination of anti-histamine and pseudoephedrine that yielded those results.

[nomore2013]

i took claritin-d 3 times already, and every time it worked.

[nomore2013]

claritin-d, contains loratadine and pseudoephedrine. pseudoephedrine acts as a vasoconstrictor, which is weird, because i thought we were supposed to be looking for vasodillators like b3-niacin, niacinimide.

can you take pseudoephedrine and niacinimide at the same time?

[Prancer]

I had some temporary success with loratadine (claritin), but then my symptoms kicked in big time next day. I haven't tried claritin-d yet.
Pseudoephedrine acts like a stimulant, and I know that caffeinated soft drinks like colas seem to help me a lot. I want to give claritin-d a try.

Last month I abstained for about 2 weeks and seemed to feel somewhat better, but I'm still very inconclusive about whether abstaining for a long time actually clears my symptoms up, which bothers me. I remember hearing that some sufferers had to wait over a month or 2 before starting to feel normal again. I want to abstain while trying all these remedies for as long as possible (for months hopefully), and if I STILL have pois symptoms after all that, well then that would suck.  :\

[kurtosis]

I had some temporary success with loratadine (claritin), but then my symptoms kicked in big time next day. I haven't tried claritin-d yet.
Pseudoephedrine acts like a stimulant, and I know that caffeinated soft drinks like colas seem to help me a lot. I want to give claritin-d a try.

Last month I abstained for about 2 weeks and seemed to feel somewhat better, but I'm still very inconclusive about whether abstaining for a long time actually clears my symptoms up, which bothers me. I remember hearing that some sufferers had to wait over a month or 2 before starting to feel normal again. I want to abstain while trying all these remedies for as long as possible (for months hopefully), and if I STILL have pois symptoms after all that, well then that would suck.  :\

Clarityn D isn't a long term treatment I'm afraid. My doctor advised against me taking it much but I have chronic sinus problems that go with my POIS and it has a decongestant effect.

Pseudoephedrine is a stimulant which encourages the body to produce adrenaline / epinephrine. This reduces the level of histamine, similar to the way getting an epi-pen injection counteracts a severe allergic reaction.
You're basically shocking your system out of the POIS state. Yeah, it works but, as I said, I can't see this being a long term solution but it does feel a lot better than POIS

Good to know it works though, especially if you have an NE before an important meeting or exam. For some people the natural mast cell stabiliser Quercetin might work great. It's a mild COMT inhibitor however, so if someone had a COMT issue (one or 2 mutations of the COMT gene) then it would inhibit and already slow catecholamine clearing mechanism. This would be really bad to combine with something like a dopamine or norepinephrine reuptake inhibitor. It may cause mania. DO NOT DO IT.

If you're not taking that kind of anti-depressant then you could give it a go. The other option it ketotifen. It might be a h1 antihistamine but it's the mast cell stabilisation you want most.
http://en.wikipedia.org/wiki/Ketotifen
Again, this is something your doctors could prescribe.
Like I've said, I think most of the symptoms are caused by inflammation mediated by mast cell release. Most of it histamine. You can clear histamine by increasing methylation (which may actually improve the POIS sufferers quality of life in every way if they have a specific methylation genetic problem) or improving mast cell stability via quercetin, ketotifen, cromolyn etc.

It all depends on genetics, the other drugs or supplements the person is taking, severity of POIS etc.

[GoingCrazy]

I had some temporary success with loratadine (claritin), but then my symptoms kicked in big time next day. I haven't tried claritin-d yet.
Pseudoephedrine acts like a stimulant, and I know that caffeinated soft drinks like colas seem to help me a lot. I want to give claritin-d a try.

Last month I abstained for about 2 weeks and seemed to feel somewhat better, but I'm still very inconclusive about whether abstaining for a long time actually clears my symptoms up, which bothers me. I remember hearing that some sufferers had to wait over a month or 2 before starting to feel normal again. I want to abstain while trying all these remedies for as long as possible (for months hopefully), and if I STILL have pois symptoms after all that, well then that would suck.  :\

I think the time I feel the best is the time furthest from my last "O" and that I still don't feel sexually frustrated. 

[GoingCrazy]

claritin-d, contains loratadine and pseudoephedrine. pseudoephedrine acts as a vasoconstrictor, which is weird, because i thought we were supposed to be looking for vasodillators like b3-niacin, niacinimide.

can you take pseudoephedrine and niacinimide at the same time?

I'm not so sure about the vasodilating/vasoconstricting effect, but more on its effect on histamine and other inflammatories.

[GoingCrazy]

Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

[John21 (OP)]

Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

I have had insomnia for many years, maybe around 12 years now. It is sleep maintenance insomnia where I wake in the middle of the night and sometimes have difficulty getting back to sleep. Stress is a definite contributor, if not the sole reason. What form of insomnia do you have GC?

[kurtosis]

Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

Yeah, I can still sleep but I find I can sleep through most things. My biggest problem with sleeping is the amount of mucous I produce which sometimes makes me snore so loudly I wake myself up. Quercetin reduced this in the past. Sometimes if I eat 2 apples, it has a similar effect and I think that's because there's quercetin in them.
Interesting open journal article on quercetin here. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033805

Had 2 O's yesterday and feel pretty good. I didn't take anything after them. I just woke up, had my NADH and some fish oil (stuff gives me no fishy burps and no stomach pain unlike some products).
I've a bit of a cold which seems like an actual cold as opposed to POIS but apart from that, pretty good.

[JACKMAN]

i read something today about mens virility today, and it said how not ejacualting when you should be, when you should be reaching climax is shocking your system and messing up your nervous system which in can turn make you impotent or far less virile. so i experienced that recently with a woman, and it hasnt happened before to me, so im guessing i should just go through with it and it would help in the future or is my POIS due to me not always climaxing when i should of done, and my body inturn reacting like this when i do climax. it all could be complete nonsense.

[Prancer]

And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

For me, I don't have any problem staying asleep, but I go to bed very late, like 1 or 2 am. I'm usually very tired in the morning because of the late bedtime but I believe mainly because of pois.

[Coreman]

HI, Im back after 24 days of BROMOCRIPTINE treatment.

PRANCER was right: it's too early to break out the champagne...

I am getting a little better, but not to the level I expected.


MY AGENDA:
Firstly, I'm seeing the specialist in 2 days who may prescribe CLOMIFENE CITRATE this time.

"CLOMIFENE CITRATE has been found very effective in the treatment of secondary male hypogonadism in many cases.[3] This has shown to be a much more attractive option than testosterone replacement therapy (TRT)" -  Wikipedia.


Secondly, I'm waiting for an MRI test to face the fact if  I  have
a PROLACTINOMA tumor. (A prolactinoma is a noncancerous pituitary tumor that produces a hormone called prolactin)

I'll  report back on the result of the MRI test and progress!

Cheers,

COREMAN.




Citation:
-----------------------

That sounds like some pretty good news Coreman. Although it's early, I'm already getting excited! Please keep us up to date on any new developments. Thanks a lot and good luck!
 - Prancer

PS: Let's give it the 2-week rule that B_Daniel suggested (wait couple weeks and see if you are still cured or feeling much better) before we really break out the champagne!

-------------------------
You're right, Prancer. Thanks! I'll give it a 2 weeks' go!
Coreman.

-------------------------
Dear Demografx and Others!
I’ve been having a BREAKTHROUGH  !!!
(Me: a member for 5 years, suffering from POIS for 10 years.)

To put it short, I’m diagnosed with Hyperprolactinaemia, taking pills and getting way better! 
http://en.wikipedia.org/wiki/Hyperprolactinaemia [nofollow]

The results of my lab tests:
(performed after a release):
Total Testo: 4,2 seriously under the range of 8,6 – 26
Prolactine:   1646 (!!) seriously over the range of 86-324

Taking Bromocriptine for 5 days, and feeling much better !!!

I met an Endocrinologist with profound knowledge.
->an adenoma tumour (so called prolactinoma) is suspected.
-> I am enlisted for an MRI test to check whether I really have prolactinoma.
Cheers!! I’m over the moon now!

Coreman."
----------------------------

[Ninjagasm]

I'm a new user so I apologize if somebody said this already...
Okay so I used to expierence severe to mild brain fog and intense fatigue everytime I orgasmed. I started taking a Vitamin B-100 Complex 100mg for the fatigue before I orgasmed and two tablets of Lecithin 120 mg for the brain fog before and after orgasm. Been "cured" ever since. Once again we are all different and react to different medication/supplements. Hope this helped

[Ninjagasm]

Oh and I'm pretty sure the key is to have a orgasm atleast 3-5 times a week or your body will never get used to the POIS. I used to be scared to orgasm because of the symptoms so I would only have one once a week. Its only been 3 days but so far so good.

[Prancer]

I'm a new user so I apologize if somebody said this already...
Okay so I used to expierence severe to mild brain fog and intense fatigue everytime I orgasmed. I started taking a Vitamin B-100 Complex 100mg for the fatigue before I orgasmed and two tablets of Lecithin 120 mg for the brain fog before and after orgasm. Been "cured" ever since. Once again we are all different and react to different medication/supplements. Hope this helped

Welcome ninjagasm, and thank you for sharing what's helped you! I'm happy to hear you are feeling better.

I bought a lecithin supplement after hearing your success story. You're right that we're all different so I'm not getting overly excited, but I'm still highly optimistic with every new supplement I try. (By the way, I now officially have amassed A LOT of different supplements. Those that don't know I have pois think that I've become a dr. oz aficionado.) I don't mind experimenting with new supplements because one day I might try the perfect one!

On another matter, for those that get pois or feel worse after a hot shower, I think I found something that helps me and might help you too. Basically I just switched my hair dryer from one that uses mainly HEAT with little air flow to dry hair to one that uses a lot of air flow and not as much heat. I have found that this has helped not only to save time by drying my hair faster, but also to eliminate most of the symptoms I felt. In my case, it might have actually been the heat from the hair dryer against my scalp that was causing most of the symptoms. So yeah, just wanted to throw that out in case someone was having a similar problem. K, bye for now!

[kurtosis]

Peopple with urticaria sometimes use a hot shower to release histamine. It feels better after a while. It all depends on the length of the shower.
See http://en.wikipedia.org/wiki/Urticaria

and more specifically http://en.wikipedia.org/wiki/Cholinergic_urticaria
I think POIS is similar to this but without the hives. I've had some rosacea but my body certainly doesn't become covered in hives. Anyway, the connection between the 2 is mast cell release of histamine etc.

[nathan123]

Just an update,

Its been after one month and one week after starting Calcium channel blocker. 

Now my intensity and frequency of the pois is reduced by great extent.  I can say approximately 60 to 70% of intensity of my POIS is reduced. 

Another interesting fact from my last 3 weeks is I will get symptoms now when I have orgasm.  I had even tried daily 4 o .  But no symtoms.  But if in case I go to bed at late night say 12 or 1, POIS symoms back but,intensity of pois is very low and will be cured in just 2 days. 

[Habibou]

that s great it is working for you for the moment Nathan !
Do you know if the 150 patients of PCH or POIS got totally cured with the flunarizine dihydrochloride?

I will start the same treatment in 3 days for over 3 months, under the supervisiory control of my GP.