[Ninjagasm]

that s great it is working for you for the moment Nathan !
Do you know if the 150 patients of PCH or POIS got totally cured with the flunarizine dihydrochloride?

I will start the same treatment in 3 days for over 3 months, under the supervisiory control of my GP.

I apologize for being a lazy bastard, but can you guys please summarize exactly what this calcium supplement or what ever it is your talking about? Thank youuuu!

[Ninjagasm]

and whats the logic behind using it??

[CertainlyPOIS]

I have a confusion about whether I have POIS or Post Coital headche and for my condition doctor told that it is a Post Coital headche illness.  So, please explain me whether my problem is a POIS by seeing the following symtoms.  By Calcium Channel blocker, my POIS has clearing now, so I want to discuss with doctor on POIS vs Post Coital headche illness. 

When I am in POIS, I have the following symtoms,

a) Brain fog, low concentration, low memory, Fatigue, burning in head, confusion
b) Depression
c) Burning eyes,
d) feeling imbalance in head
e) Abnormal breathing
f) High Anxiery
g) Difficult to have eye contact
h) Stammerting at the great extent
i) Imbalance in sleep and excessive dreaming
j) Emotional imbalance
h) Very rare occasion I also had throat infection.
and I don't get any flu and physical symtoms.
These symtoms will be there for atleast one months and very difficult to remove when attacked.  Upto last 2 months, my symtoms as explained above.  Please clarifiy to me.

you have pois. Do you even get any headaches after orgasm.
you can crosscheck your symptoms with dr waldingers symptoms list and you will see your symptoms match alot of the symptoms.

[kurtosis]

and whats the logic behind using it??

Pretty much the exact opposite of a calcium supplement. Indeed, I think some people have gotten confused and started taking extra calcium which would make things worse. 
Calcium channel blockers are described here
http://en.wikipedia.org/wiki/Calcium_channel_blocker
They are used to reduce blood pressure, prevent epileptic seizures or to reduce frequency or severity of migraines. I don't know whether they're safe to use long term but the argument is that POIS symptoms (and this sounds reasonable to me) are actually similar to post coital headache.

Nathan is using this http://en.wikipedia.org/wiki/Flunarizine
Which is both an anti-histamine and a cerebrovascular dilator, i.e. it relaxes blood vessels in your brain See http://dpic.org/sites/default/files/pdf/DIR_CCBs.pdf

[B_Daniel]

fyi: I've been using DAOsin for a couple weeks and it hasn't helped my digestion issues at all.

[GoingCrazy]

Kurtosis, can you take claritin-D and still fall asleep after?  I know you mentioned the pseudoephedrine as a stimulant.  I guess I haven't tried that either, I tried the claritin 24 hour, and like Prancer said you sometimes feel it the next day.  Do you get the same reaction of feeling POIS the next day?



And... on a last note... Does anybody experience sleeping problems like I do?  I would like to know if it is related to POIS or not, or maybe it's just me being anxious because of this condition.

I have had insomnia for many years, maybe around 12 years now. It is sleep maintenance insomnia where I wake in the middle of the night and sometimes have difficulty getting back to sleep. Stress is a definite contributor, if not the sole reason. What form of insomnia do you have GC?

Usually when I sleep, it's like I cannot "relax", sort of my brain doesn't shut off, and I can't get into the mood of calmness/relaxation.  Sometimes I'll wake up in the middle of the night sweating and nervous, so it almost seems like a symptom of anxiety, but I don't know if POIS is the cause or something else.

But recently I've been sleeping well just by taking vitamin C in the morning (Ester C), I think its reaction with histamine is causing me to sleep better throughout the night even though I take it in the morning.

[GoingCrazy]

I'm a new user so I apologize if somebody said this already...
Okay so I used to expierence severe to mild brain fog and intense fatigue everytime I orgasmed. I started taking a Vitamin B-100 Complex 100mg for the fatigue before I orgasmed and two tablets of Lecithin 120 mg for the brain fog before and after orgasm. Been "cured" ever since. Once again we are all different and react to different medication/supplements. Hope this helped

Do you have any other symptoms besides brain fog?

[Ninjagasm]

Do you have any other symptoms besides brain fog?
[/quote]

Intense fatigue, headache, very irritable, mentally unstable in general, insomnia, feeling of intense heat, my pain tolerance goes down, if i go to the gym the amount of weight I can lift goes down about 25 pounds, anxiety

[Kingkong]

Hi everybody, I have good news. I've tried flunarizine (sibelium) as Nathan. I'M taking 10 mg each days since november 19th. On december 5th I had an O for the first time since two month. I had a normal night of 8 hours. The nightmares were very light. When I wook up the 6th, it was difficult but not as usually when I'm having an O. I was tired the 6th at work. I`m working in an office. Yesterday the 6th, I had a second O. I went to bed at 20 o'clock because I was very tired and I wake up at 6 this morning. So I sleep 10 hour last night. I would say that all my symptoms were gone by 10 o'clock this morning. Yesterday, I could felt a physical fatigue but about 50% mental fatigue that I have usually. Yesterday, I could felt my ganglion a bit but today absolutly nothing. IT's a lot more efficient than NIACIN. Today I had no irritability at all and no mental problem. It's a very big succes for me. I'M must say that the first 10 day that I began to take Sibelium, I was sleeping 10 hour a day and I was tired. But now it's OK. My doctor told me that by 8 weeks of taking Sibelium, I will be very hungry and could take 10-20 pounds. I will have to control myself not to eat too much. I'm continuing to take flunarizine and I 'll give more news later. I'm 53 yers old and I never felt good like that since 14 year the after I had an O. As I wrote on november 20th on this site, I'm taking citalopram for many years. Maybe i't for that reason that I was so tired de first 10 days of taking flunarizine.

[CertainlyPOIS]

Hi everybody, I have good news. I've tried flunarizine (sibelium) as Nathan. I'M taking 10 mg each days since november 19th. On december 5th I had an O for the first time since two month. I had a normal night of 8 hours. The nightmares were very light. When I wook up the 6th, it was difficult but not as usually when I'm having an O. I was tired the 6th at work. I`m working in an office. Yesterday the 6th, I had a second O. I went to bed at 20 o'clock because I was very tired and I wake up at 6 this morning. So I sleep 10 hour last night. I would say that all my symptoms were gone by 10 o'clock this morning. Yesterday, I could felt a physical fatigue but about 50% mental fatigue that I have usually. Yesterday, I could felt my ganglion a bit but today absolutly nothing. IT's a lot more efficient than NIACIN. Today I had no irritability at all and no mental problem. It's a very big succes for me. I'M must say that the first 10 day that I began to take Sibelium, I was sleeping 10 hour a day and I was tired. But now it's OK. My doctor told me that by 8 weeks of taking Sibelium, I will be very hungry and could take 10-20 pounds. I will have to control myself not to eat too much. I'm continuing to take flunarizine and I 'll give more news later. I'm 53 yers old and I never felt good like that since 14 year the after I had an O. As I wrote on november 20th on this site, I'm taking citalopram for many years. Maybe i't for that reason that I was so tired de first 10 days of taking flunarizine.

I looked it up and that is one of the side effects of sibelium.
Also do you have any physical symptoms like fatigue,and fluelike symptoms.

Not saying this because of flunarizine success with some. But my first true O with another person produce the most most worst worst headache ever. I dont know how to explain it " the pain level felt like i busted a vein in my head and that pain lasted all day i couldnt get out of bed."
The only problem is, it only happened that time and never since.  And i did not notice any pois symptoms untill about three months from that day.

[CertainlyPOIS]

according to this it looks like calcium channel blocker act differently in the body.
And Flunarizine and nimodipine are the only ones who pretty much just affect the brain.
http://dpic.org/sites/default/files/pdf/DIR_CCBs.pdf

if you trying this you should probabbly stick to just flunarizine.

[B_Daniel]

Pseudoephedrine is a stimulant which encourages the body to produce adrenaline / epinephrine. This reduces the level of histamine, similar to the way getting an epi-pen injection counteracts a severe allergic reaction.
You're basically shocking your system out of the POIS state. Yeah, it works but, as I said, I can't see this being a long term solution but it does feel a lot better than POIS

Reallly good point Kurtosis! For the last month, it's become increasingly obvious to me that POIS is, at its heart, a histamine problem. As confirmation of this, ive found that foods high in histamine make me feel worse, and supplements that break down histamine, like Sam-E, make me feel a lot better!!

The only part of this theory that was still bugging me though was understanding why caffeine and ritilin make me feel better. What does that have to do with too much histamine? 

As u so precisely explain above, adrenaline clears histamine instantly, giving us relief. And then as u also wrote in another post, this explains why we get worn out so easily, mentally and physically. All day every day we have a high level of adrenaline in order to fight the high histamine.  Consequently, we have adrenal fatigue from using too much adrenaline all the time!  it makes so much sense!

I found a website a guy wrote about his problems breaking down histamine. Youll see how eerily familiar it sounds to pois.  It also explores this link with adrenaline (also know  as epinephrine).

Clip from guy's blog:
Adrenaline (Epinephrine) is the only chemical that can quickly eliminate histamine in a person. So called "antihistamines" like Benadryl only work to block some of your body's histamine receptors relieving some histamine related symptoms, they do not remove histamine. If you do go into anaphylactic shock where your organs essentially shut down, it is essential that you are injected with adrenaline immediately to counteract the dangerously high histamine level and prevent death. My histamine level was very high but not dangerous. My body tried in vain to reduce this high level of histamine to a normal level, by releasing abnormally large quantities of adrenaline into my blood stream. This created nervous energy and sometimes even panic attacks if the spikes were large enough. The body normally has a certain amount of adrenaline that increases and decreases slightly to balance your body's histamine level. In its attempt to reduce my histamine level, my body would essentially use up all my adrenaline (as shown by my blood test). This would leave me feeling anywhere from moderately tired to frighteningly exhausted. Its probably difficult to imagine being so drained of energy that it would actually scare you, but it happened to me frequently. My high histamine level also caused my Meniere's like symptoms, as well as difficulty thinking, focusing, and remembering things.

[kurtosis]

This would leave me feeling anywhere from moderately tired to frighteningly exhausted. Its probably difficult to imagine being so drained of energy that it would actually scare you, but it happened to me frequently

And epinephrine is made from norepinephrine and that's made from dopamine so the effort reduces available dopamine, possibly leading to lower metabolites of dopamine in the urine (e.g. DOPAC).

That's what I think anyway but I'm going to hold out until I see the genetic tests before making a decision about how best to deal with this. If there's no obvious methylation problem that could be affecting breakdown of histamine then possibilities include too many mast cells or mast cell instability (so a mast cell stabiliser may be the answer) or another possibility is, genuinely, a parasitic infection of some sort which may lead to increased histamine levels, impaired digestion and other problems that could account for POIS.

[Prancer]

If someone were to use an epinephrine auto injector (like EpiPen), would this instantly clear his pois symptoms? I'm just wondering & not recommending that anyone try this by the way.

[CertainlyPOIS]

If someone were to use an epinephrine auto injector (like EpiPen), would this instantly clear his pois symptoms? I'm just wondering & not recommending that anyone try this by the way.

Counterpoint tried this and it didnt work for him.

[Kingkong]

Hi everybody, I have good news. I've tried flunarizine (sibelium) as Nathan. I'M taking 10 mg each days since november 19th. On december 5th I had an O for the first time since two month. I had a normal night of 8 hours. The nightmares were very light. When I wook up the 6th, it was difficult but not as usually when I'm having an O. I was tired the 6th at work. I`m working in an office. Yesterday the 6th, I had a second O. I went to bed at 20 o'clock because I was very tired and I wake up at 6 this morning. So I sleep 10 hour last night. I would say that all my symptoms were gone by 10 o'clock this morning. Yesterday, I could felt a physical fatigue but about 50% mental fatigue that I have usually. Yesterday, I could felt my ganglion a bit but today absolutly nothing. IT's a lot more efficient than NIACIN. Today I had no irritability at all and no mental problem. It's a very big succes for me. I'M must say that the first 10 day that I began to take Sibelium, I was sleeping 10 hour a day and I was tired. But now it's OK. My doctor told me that by 8 weeks of taking Sibelium, I will be very hungry and could take 10-20 pounds. I will have to control myself not to eat too much. I'm continuing to take flunarizine and I 'll give more news later. I'm 53 yers old and I never felt good like that since 14 year the after I had an O. As I wrote on november 20th on this site, I'm taking citalopram for many years. Maybe i't for that reason that I was so tired de first 10 days of taking flunarizine.

I looked it up and that is one of the side effects of sibelium.
Also do you have any physical symptoms like fatigue,and fluelike symptoms.

Not saying this because of flunarizine success with some. But my first true O with another person produce the most most worst worst headache ever. I dont know how to explain it " the pain level felt like i busted a vein in my head and that pain lasted all day i couldnt get out of bed."
The only problem is, it only happened that time and never since.  And i did not notice any pois symptoms untill about three months from that day.

Yes I was very tired the first 10 day that I took Sibelium. But gradualy, the fatigue and the fluelike symptom's diseapar. Flunarizine takes two months to reach full efficient. I'm trusting my doctor when he told me that was no contraindication to take this drugs. He his 64 years old and he prescribed flunarizine a lot for headache in the past. For him is a good drug even because he had no problem in the past whit his patient taking flunarizine.

[Kingkong]

i took claritin-d 3 times already, and every time it worked.

I've tried claritin during two week two month ago and I had no benifit using that. It gave me ligh headache only.

[B_Daniel]

If someone were to use an epinephrine auto injector (like EpiPen), would this instantly clear his pois symptoms? I'm just wondering & not recommending that anyone try this by the way.

Counterpoint tried this and it didnt work for him.

Did he?  Certainly, will you share with us the quote from the forum where he says he tried it??  I searched the forum for Epipen and saw Counterpoints say that he owned one, but didn't see him say that he had ever used it.  Unfortunately we can't ask him because somebody banned him.

I've never used an epipen, and they're dangerous to try when not absolutely necessary so don't be a hero, but I'm fairly confident we'd feel instantly better.  Anyone else have experience with an epipen??

[CertainlyPOIS]

How does the peanut alergy feel relative to POIS symptoms?

I have a severe (life threatening) allergy to peanuts, and it feels nothing like POIS.  The treatment (a shot of adrenaline) does not seem to have an effect on POIS symptoms.  (If it does it probably helps a little, but there isn't enough evidence for me to say).

However, this does not discredit Waldinger's hypothesis.  Auto-immune reactions (e.g. lupus) can be quite different from normal allergic reactions.

This is one of the places he said he tried ephipnephrine.

[B_Daniel]

How does the peanut alergy feel relative to POIS symptoms?

I have a severe (life threatening) allergy to peanuts, and it feels nothing like POIS.  The treatment (a shot of adrenaline) does not seem to have an effect on POIS symptoms.  (If it does it probably helps a little, but there isn't enough evidence for me to say).

However, this does not discredit Waldinger's hypothesis.  Auto-immune reactions (e.g. lupus) can be quite different from normal allergic reactions.

This is one of the places he said he tried ephipnephrine.

Not to completely discount his statement but keep in mind this is A) only 1 data point, and B) When he's used the epipen, he's also suffering from anaphylactic shock from his peanut allergy, which i'd imagine would obscure his view of the results.