[underwater]

Michael--
Thank you very much for such a comprehensive explanation.

[girlwind]

Hi all,

I report back now after several months of no symptoms of POIS that I have fully cured my POIS by reimbalancing my hormone  and neurotransmitter levels.No more depression, mood swings, headaches/mirgraines/foggy brain/muscle and joints pain, exhaustion, inflammation of the eyes, stomach bloating, indigestion, diaheera, stomach pain & cold,flu like symptoms after an orgasm.

THANKS MICHAEL for your posting! I also want to thank you publicly for getting me on the right track with
all the hormone balancing info that you provided for me, and your input on my test results back a few months ago.
It wasvery helpful in initiating by interest in this subject of the endocrine hormones, and in giving me direction on
how to proceed.

MANY PEOPLE ON THIS FORUM have been waiting for your return with your very positive end results, so I'm
hoping they will take advantage of the situation to ask you all the questions they need and want to ask.

[underwater]

Michael8028----
Thanks again. I have a follow up question regarding gaba. You indicate you took it sublingually. Could you tell me if you still take it? If so, what is your dosage?
What time of day do you take it? Do you take it daily? Do you take it alone, or with any other drugs/supplements? What is the brand? How long have you been taking it?

Regarding 5htp, how did you come to choose orange juice as the preferred method for ingesting 5htp? How does orange juice broken down in the stomach and intestines assist 5htp in reaching appropriate receptors in the brain? Do you still take it? What is your dose? What is your brand? Do you take it alone? How long have you been taking it?

I very much appreciate your contributions & looking forward to your answers-------

[mister_z]

some of you mention an impressive variety of hormonal tests; myself i had to argue endless to have my doctor finally give up and have me get a free testosterone test.. how does one actually gets his/her M.D to agree to specific tests? i am due to redo the testosterone once again to be sure and eventually take testosterone pills... (i am well below normal, which is strange i always thought id be in the high end of normal range)
but id like to get some other tests done, like prolactin for instance; even electrolytes i cant get my doc to agree to ! if only i had the possibility to write my own prescriptions i bet all my health problems would be sorted by now (i do my research very carefuly and even out of plain scientific curiosity)... instead i have to beg (almost) to get anything decent out of my doc.. (and all docs are the same where i live)
i wanted to ask you guys also, i dunno if it has been mentioned here, if anyone has tried tyrosine (at high dose)/phenylalanine, lysine or glutamine (at high dose too)
i have been testing glutamine (perhaps at not high enough a dose, literature mentions very high doses around 10g), also tyrosine, which in itself has given a little general boost, as in, feeling less out of it. (of course thats what i expected since it boosts dopamine)

[girlwind]

some of you mention an impressive variety of hormonal tests; myself i had to argue endless to have my doctor finally give up and have me get a free testosterone
test.. how does one actually gets his/her M.D to agree to specific tests?

but id like to get some other tests done, like prolactin for instance; even electrolytes i cant get my doc to agree to ! if only i had the possibility to write my own prescriptions i bet all my health problems would be sorted by now (i do my research very carefuly and even out of plain scientific curiosity)... instead i have to beg (almost) to get anything decent out of my doc..  (and all docs are the same where i live)

MISTER Z--You are in luck and your wish has come true. There really is a place where YOU can order your own blood tests.
and here it is. 

 https://www.mymedlab.com/tests.php

[Michael8028]

Michael8028----
Thanks again. I have a follow up question regarding gaba. You indicate you took it sublingually. Could you tell me if you still take it? If so, what is your dosage?
What time of day do you take it? Do you take it daily? Do you take it alone, or with any other drugs/supplements? What is the brand? How long have you been taking it?

Regarding 5htp, how did you come to choose orange juice as the preferred method for ingesting 5htp? How does orange juice broken down in the stomach and intestines assist 5htp in reaching appropriate receptors in the brain? Do you still take it? What is your dose? What is your brand? Do you take it alone? How long have you been taking it?

I very much appreciate your contributions & looking forward to your answers-------

Hi underwater,

You are very welcome and Iam glad my post was helpful to you.

When i first took Gaba supplements it was in the form of powder or capsules. I had to take high doses just to feel the calming effect and raise the gaba levels slightly. 1-2 grams was common daily.

Iam not sure if the gaba supplements in powder or pills were of bad quality or maybe it just wasnt crossing the blood brain barrier but shortly changing to Source naturals Gaba calm sublingual even at 2 tabs(gaba amount 125mg a tab) a day it was enough and Gaba levels reached the optimal level.

I take 1 tab in the morning usually and 1 tab again whenever I feel I require it, can be anytime.Yes i still continue to use the Source Naturals Gaba Calm. I plan to reduce it to 1 tab a day in the next month and if all is well to stop it completely within 2 months.



Well I had been taking 5htp up to 600mg a day  from pills to capsules and I definetly felt some effects in helping my anxiety, nervousness and mood post orgasm but it was costly at such a high dose and had a feeling the 5htp wasn't assimilated properly or that it wasn't crossing the blood brain barrier.

During my daily research I came across a poster on the mesomorphosis forum who had low serotonin levels and was taking 300/400mg of 5htp a day.

In his post he said dispite taking this high amount of 5htp his low serotonin levels only increased slightly and was no where near the optimal level. Later on his physician/MD had advised him to drink a glass of Orange juice on an empty stomach before taking 5htp to help the assimilation process and to avoid any proteins for 1 hour.

Well after 6 weeks of this strategy my serotonin levels rose to inside the optimal range. With the orange juice and empty stomach I only needed 300mg a day and now Iam currently taking 100-200mg a day but not everyday just whenever I feel the need.

I cant always go by urine neurotransmitter anaylsis so symptoms will have to do for now

Sorry I do not have the answer to your question of the how part but Iam sure there are studies on pubmed unless this was the posters physicians own theory?

I wouldnt advise anyone to just start supplementing gaba or 5htp as you could have optimal levels or even worse, high levels of gaba and serotonin.I would recommend a neurotransmitter urine anaylise to confirm these levels.

Hope this is helpful Underwater,

Michael

[Michael8028]

deloun,B_Jim, girlwind & CCconfucius.

Thank you for your kind words and I'am glad my post of my experiences has been helpful to you all.

It was my pleasure to help you in our pms, girlwind and CCconfucius.Iam very happy that you had faith in looking into the hormone side of things and wish you all the best of luck in treating and curing Pois.

[martin88]

Hi Deloun,
Your results are remarkably helpful, thank you for reporting. Were these tests asked by a naturopathic doctor ?

Hi martin88, you're welcome, it would be nice if it could be of any help to anyone here.
 
A little while ago I've done some research for a while to look for any substances that could be related to my POIS symptoms and that I could get tested with laboratory research. As a result I requested application forms for tests, at the European Laboratory of Nutrients (ELN) (1), a well regarded laboratory situated in the Netherlands, which has a connection to another well regarded laboratory in the USA, Vitamin Diagnostics. I filled in requests for many things that in my view and according to the research that I have done, could be related in any way to my POIS symptoms. After that I went to my local doctor and asked for a referral to a medical center in the Netherlands, Medisch Centrum (Medical Center) Rhijnauwen in Bunnik (2), who has a connection to the ELN. In this way all costs were covered by my basic health insurance in the Netherlands, except for one test, the Melisa test. For anyone who wants to get some things tested, I can recommend these two laboratories and for anyone who lives in or near the Netherlands I can recommend to do it via the Medisch Centrum Rhijnauwen (MCR) (2) to get a chance of getting the costs covered by insurance, but I recommend to always check the current state of possibilities to get it covered (I did it end of last year, so things could have changed this year) and to contact the MCR (2) about it, which I also did beforehand.

After the results were in, I've made appointments to two different orthomolecular doctors, Kim van Wetten at the MCR (2) and Robert Trossèl at the PMC Rotterdam (3), which I can both recommend and in my opinion it can never hurt to check with two different doctors.

(1) http://europeanlaboratory.com
(2) http://www.medischcentrumbunnik.nl
(3) http://www.preventiefmedischcentrum.nl

Thanks a lot for these precisions. Very good thing to have this paid by insurance ! Unfortunately I'm not in your country but other people will be able to take this path. The results of your tests will be helpful for all of us. With time we'll have more and more tests/treatments done and we'll be able to see what is relevant for pois.

To remove your mercury, not all dentists have the right equipment to do this. (Maybe you know this already..)  Take someone who is qualified and who have the required material (expensive). Otherwise you can do more harm than good. 

[martin88]

Thanks for this report Michael. Your experience and treatment is very complex (at least for me!).
How do you explain that a case of pois had higher testosterone while in POIS (maybe my case too) ?

When you say your estrogens were elevated do you know why ? (was it only the testosterone treatment or an other reason too)

Also I tried GABA pills and I felt very edgy and agitated with bad sleep as well. Did you experience such a thing? Maybe my GABA was too high.
 

[Michael8028]

You are very welcome Martin88,

Can you provide the levels and ranges for the testosterone test for on and off POIS symptoms
and any other hormones that were tested during this period?

I really could not explain if someone did have higher testosterone levels during POIS than when not
experiencing symptoms of POIS without a full hormone profile.It would not make logical sense if the person was experiencing symptoms of POIS and had higher testosterone levels than when not in POIS since most of us do experience lower energy, drive, libido etc when in POIS unless this case is unique.

It is a puzzle to me what caused my estrones and estriol to be elevated yet my Estradiol in relative to my E1 & E3 Estrogens were low.My estrogen metabolic pathways must have been backed up and the Estrone was unable to convert to Estradiol.

Testosterone replacement does not convert to
Estrone & Estriol but a certain amount does convert to Estradiol (E2) depending on the individual.

I do not recall a similar effect with Gaba but you could be right with present elevated Gaba levels.

Best to get everything tested to make sure.

[deloun]

[...]
To remove your mercury, not all dentists have the right equipment to do this. (Maybe you know this already..)  Take someone who is qualified and who have the required material (expensive). Otherwise you can do more harm than good. 

Thank you for reminding me for this, I have also received your PM about it.
I have thought about making an appointment with a dentist that is specialized in removing mercury amalgam fillings, but in the end I have chosen to make the appointment with my own dentist, for the beginning of march. But I have asked him to take extra precautions to limit the risks involved regarding the mercury. I have asked him to make use of the Scania Dental Clean Up (1), which is some kind of vacuum cleaning device that should be placed around the tooth, and a rubber dam (cofferdam). I have also asked him to clean any residues of amalgam, that are left over after the fillings have been removed. I hope that this is enough, what do you think, do you have any other suggestions?

(1) http://www.xs4all.nl/~stgvisie/AMALGAM/NL/cleanup.htm

[Michael8028]

I dont know if this has been mentioned before but it is to do with chemical imbalance :

Undermethylation and OverMethylation

My Histamine levels came back constantly near the bottom range which could indicate OverMethylation and
High Histamine levels could indicate Undermethylation.

I knew I was in the side of OverMethylation due to the symptoms I had at the time like :

High anxiety, nervousness
Social isolation
Academic underachievement
Dry eyes
Depression and despair
Food and chemical sensitivities
Low libido
Heavy body hair
Restless legs
Learning disabilities
Upper body or head pain
Panic attacks
Paranoia
Increased dopamine

Most of these symptoms were increased after an orgasm.

It is very rare to be Overmethylation as most people are Undermethylation.

Here are the symptoms for Undermethylation:

Allergies
Headaches
Competitiveness
Excess saliva
Obsessive-compulsive
Perfectionism
Easy tears
High libido
Addictive tendencies

More details here :

http://www.alternativementalhealth.com/articles/walshMP.htm

&

http://anabolicminds.com/forum/male-anti-aging/114485-undermethylation-overmethylation.html

[deloun]

I have also supplemented with GABA recently, but it wasn't very effective. But I haven't taken it with orange juice. Maybe there has to be enough vitamin C available for it to be effective?

I have taken magnesiumtaurate recently though, which was more effective at reducing the tension. Laboratory tests also showed a deficiency of taurine in my urine and a low value in my blood.

[deloun]

I dont know if this has been mentioned before but it is to do with chemical imbalance :

Undermethylation and OverMethylation

My Histamine levels came back constantly near the bottom range which could indicate OverMethylation and
High Histamine levels could indicate Undermethylation.

I knew I was in the side of OverMethylation due to the symptoms I had at the time like :

High anxiety, nervousness
Social isolation
Academic underachievement
Dry eyes
Depression and despair
Food and chemical sensitivities
Low libido
Heavy body hair
Restless legs
Learning disabilities
Upper body or head pain
Panic attacks
Paranoia
Increased dopamine

Most of these symptoms were increased after an orgasm.

It is very rare to be Overmethylation as most people are Undermethylation.

Here are the symptoms for Undermethylation:

Allergies
Headaches
Competitiveness
Excess saliva
Obsessive-compulsive
Perfectionism
Easy tears
High libido
Addictive tendencies

More details here :

http://www.alternativementalhealth.com/articles/walshMP.htm

&

http://anabolicminds.com/forum/male-anti-aging/114485-undermethylation-overmethylation.html

I have also recently mentioned poor methylation a few posts back, I've also been thinking about it, and according to my laboratory test results a orthomolecular doctor diagnosed poor methylation among other things.

I have bookmarked some other interesting stuff somewhere of the Pfeiffer Treatment Center about methylation and other interesting stuff, let me see if I can find it...

[deloun]

Hm, they have changed the website and I can't find it anymore at the moment.

[Michael8028]

Hi Deloun,


Not a worry, Iam sure it will pop back up sometime.

Good thing your doc tested you and confirmed undermethylation.
I wonder what your doc's treatment is for your undermethylation?

[deloun]

I have uploaded the laboratory test results regarding mercury to picasaweb. Any comments and questions are welcome, also if you've had similar tests / results I would be interested to know.

You have to enlarge them for a better view, by clicking the magnifying glass in the upper right corner, I also recommend to disable the sidebar to the right to get a better view, by clicking the arrow in the upper left corner of the sidebar.

You can find the test results here.

Edit: I removed the suggestion to make specific comments at the results at picasaweb, because it didn't seem very useful after all. But instead all comments can better just be posted here on the forum regarding the results.

[deloun]

Hi Deloun,


Not a worry, Iam sure it will pop back up sometime.

Good thing your doc tested you and confirmed undermethylation.
I wonder what your doc's treatment is for your undermethylation?

Hi michael,

Well, she has prescribed a lot of supplements, but not a specific methylation donor as far as I know, though probably other things are among the prescribed supplements that can support better methylation. I haven't taken the prescribed supplements yet though.

[deloun]

I have tried SAMe (s-adenosyl-methionine) recently though, which is considered a methylation donor, but it wasn't very effective. According to my experience I began searching through scientific research online and found results that showed that SAMe itself isn't very effective in raising SAMe levels in the brain and central nervous system. Besides that the results showed that methionine, which is a direct precursor to SAMe, was much more effective in increasing the SAMe levels in those areas. Methionine is also considered an effective methylation donor in general. So I'm considering to try to supplement methionine.

[deloun]

My laboratory test results also show a deficiency of methionine by the way.