Post Orgasmic Illness Syndrome (POIS)

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Offline Bizzy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #500 on: 09/05/2008 01:11:16 »
After full ejaculation or orgasm a signal is sent from the testicles to the hypothalamus for the release of GnRH. The GnRH hormone travels from the hypothalamus to the pituitary and stimulates gonadotropin release. Gonadotropins travel to the testicles and stimulate testosterone production. This system is known as the HPG axis ( hypothalmic-pituitary-gonadal axis ).
Maybe in POIS, after ejaculation, rather than the HPG axis, the HPA axis gets activated. The HPA axis ( hypothalmic-pituitary-adrenal axis ) is responsible for releasing stress hormones including cortisol. This would mean that the end result after ejaculation would be more stress rather than more testosterone.

Research needs to be done as to why this axis crossover occurs.
Do you see how the adrenals are downstream from the true source of the problem, which is the hypothalamus ?
« Last Edit: 09/05/2008 12:16:28 by Bizzy »

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Offline solution

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #501 on: 10/05/2008 06:45:55 »
Brain DHEA levels were significantly decreased by vitamin E deficiency in rats.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #502 on: 10/05/2008 18:16:02 »
After full ejaculation or orgasm a signal is sent from the testicles to the hypothalamus for the release of GnRH. The GnRH hormone travels from the hypothalamus to the pituitary and stimulates gonadotropin release. Gonadotropins travel to the testicles and stimulate testosterone production. This system is known as the HPG axis ( hypothalmic-pituitary-gonadal axis ).
Maybe in POIS, after ejaculation, rather than the HPG axis, the HPA axis gets activated. The HPA axis ( hypothalmic-pituitary-adrenal axis ) is responsible for releasing stress hormones including cortisol. This would mean that the end result after ejaculation would be more stress rather than more testosterone.

Research needs to be done as to why this axis crossover occurs.
Do you see how the adrenals are downstream from the true source of the problem, which is the hypothalamus ?


Bizzy, this is excellent. Now, do you have any suggestions as to how we can take this to the next step? Recruit a research scientist for this Forum? Thank you!

ps - I wouldn't wish POIS on a poor rat [;D]
« Last Edit: 10/05/2008 18:26:11 by demografx »

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Offline msl

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #503 on: 11/05/2008 09:19:32 »
Hi guys, Thank you very much for replies, they mean a lot. Its reassuring to know there are people out there who understand. I had another nocturnal emission last night :/ but as you can see.. Im still here...

I do not know if this has already been posted but i found this article:
newbielink:http://www.reuniting.info/science/sex_and_addiction [nonactive]
particularly go down to sex's hidden hangover

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Offline John21

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #504 on: 11/05/2008 11:50:58 »
... sex outside of love (oxytocin) is dangerous.

This glove fits perfectly on the hand of Christian theology.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #505 on: 12/05/2008 21:13:42 »
TO RAPIDGAMING

Welcome back!

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #506 on: 12/05/2008 21:25:28 »

Demografx feels much better with dopaminergic Levitra.


B_JIM,

I don't know if you saw my previous question. I'm sorry if I missed your reply.

(1) I asked if you can please explain what you mean by "dopaminergic Levitra"

(2) And you also referred to Levitra in another post as a "stimulant".

Would you kindly explain?

Thank you!
« Last Edit: 12/05/2008 21:27:26 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #507 on: 12/05/2008 21:30:29 »
Hi guys, Thank you very much for replies, they mean a lot. Its reassuring to know there are people out there who understand. I had another nocturnal emission last night :/ but as you can see.. Im still here...

I do not know if this has already been posted but i found this article:
http://www.reuniting.info/science/sex_and_addiction
particularly go down to sex's hidden hangover

RAPIDGAMING,

Very interesting article! I think it agrees with B_JIM's theories.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #508 on: 12/05/2008 21:36:46 »
QUESTION TO ALL

Does anyone else feel this way: For me, POIS symptoms feel like NOTHING ELSE I experience, either when I'm sick or well. They are unique. The drain of energy is different. My fingertips feeling drained are so unusual, there is nothing else like that feeling in my life. How does everyone else feel with POIS symptoms? Are they similar to any other symptoms in your life? Please let me know.

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Offline Bizzy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #509 on: 13/05/2008 01:00:34 »
Demografx, I agree the symptoms are very unique. There is a huge lack of physical and mental energy. Severe depression is the most significant illness I experience. I wonder if this is true for others ?

Demografx, you asked me above what the next step should be. I think a letter should be sent to the head of research endocrinology directed at several universities. Within the letter outline a discription of the illness and call it POIS. Make a reference to this forum with its URL.
« Last Edit: 13/05/2008 01:24:02 by Bizzy »

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Offline hk1979

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #510 on: 13/05/2008 19:31:05 »
my POIS is similar to things I do that deplete my adrenaline, like playing soccer or rugby for more than 2 hours, I get very tired and sometimes nauseas, dehydrated. if anyone plays tennis or squash or does very physical extreme sport for more than 3 hours, tell us if your feelin the day afterwards is similar to POIS. I guess if you are fit, then your POIS is also not as bad as the days when you were unfit? With fit I mean trained to endure long physical activity, and good lung pump to muscular and nervous system.

A good indication may be: does POIS make your legs and arms stiff. Like you feel you cannot stretch them easily?

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Offline msl

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #511 on: 14/05/2008 09:21:42 »
My POIS symptoms are unique, different to when I have done lots of sport. Mine include

Mental Fog, Can't concentrate or think logically, work things out or recall necessary things.
Severe Depression
a little physical fatigue and headache
Large pupils

Actually to mention on that stretching thing i did find it harder to stretch in a pois cycle, and I used to do lots of  hard stretching. I also have pretty bad OCD

And guess what, i had another wet dream last night! and I have an A2 Module tomorrow! Doesn't it just make you glad to feel alive..

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #512 on: 14/05/2008 19:15:54 »
Demografx, I agree the symptoms are very unique. There is a huge lack of physical and mental energy. Severe depression is the most significant illness I experience. I wonder if this is true for others ?

Demografx, you asked me above what the next step should be. I think a letter should be sent to the head of research endocrinology directed at several universities. Within the letter outline a discription of the illness and call it POIS. Make a reference to this forum with its URL.

This is an excellent idea, Bizzy! I can help research the universities' email addresses, but would anyone here be willing to step forward and draft a letter? I don't feel that my writing is scientific enough.

HELLO FELLOW POIS SUFFERERS! **ANY VOLUNTEERS?**

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #513 on: 14/05/2008 19:30:59 »
TO B_JIM

B_Jim, thank you very much! That is a fascinating explanation of what happens with Levitra.

Calm?  [;D] Not me! Haha.

Even with a 75% POIS-cure with Levitra, I am so sick and tired of the POIS symptoms - even "only" one day - that I still avoid sex these days.

B_Jim, maybe we can work together? Maybe you can help to begin a draft of a letter - as Bizzy suggested - to universities and I can help to edit it? Your scientific understanding is much better than mine and I can help with grammar, punctuation, spelling, etc. If you agree, either post here or feel free to email me.

Thanks!
« Last Edit: 14/05/2008 21:41:11 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #514 on: 14/05/2008 19:34:45 »
My POIS symptoms are unique, different to when I have done lots of sport. Mine include

Mental Fog, Can't concentrate or think logically, work things out or recall necessary things.
Severe Depression
a little physical fatigue and headache
Large pupils

Actually to mention on that stretching thing i did find it harder to stretch in a pois cycle, and I used to do lots of  hard stretching. I also have pretty bad OCD

And guess what, i had another wet dream last night! and I have an A2 Module tomorrow! Doesn't it just make you glad to feel alive..


RAPIDGAMING, I'm sorry to hear about the dream again, but at least your spirits and sense of humor have improved! ("doesn't it just make you glad to feel alive"---haha)

Best wishes, RAPIDGAMING !
« Last Edit: 14/05/2008 20:25:26 by demografx »

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Offline hk1979

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #515 on: 15/05/2008 15:32:46 »
rapidgaming

thank you very much for the article you posted, it made very interesting reading, and also changed my perception on dopamine! I always felt without ambition with POIS but never guessed it is dopamine.

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Offline jeroboam

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #516 on: 15/05/2008 16:03:42 »


I do not know if this has already been posted but i found this article:
newbielink:http://www.reuniting.info/science/sex_and_addiction [nonactive]
particularly go down to sex's hidden hangover

RAPIDGAMING,

Very interesting article! I think it agrees with B_JIM's theories.
Quote for the truth! I've read about this dopamine-dropping phenomen before.


I think the better way of solving the problems this "Syndrome" is causing, is to prevent it from happening. Everytime a man ejaculates he loses valuable semen. And obviously it also has an effect on various complex regulating systems for varieble substances in the mind and body. This causes us to feel tired, sexually not interested, etc.. for quite a while.


My view on the situation is that everyone suffering from this should learn to have an orgasm withouth ejaculation. I think the ejaculation and not the orgasm itself triggers all these "bad" things to happen.
There's only advantages to come from learning this. This way you can also experience the good effects off having sex with a partner. (i.e. longevity instead of dying sooner by wasting valuable semen)

It all comes down on training your PC-muscle. But be careful! This muscle is easy strained, and this works contraproductive.
For all who wants to learn this, I've uploaded a book at newbielink:http://rapidshare.com/files/115102010/allnight.zip.html [nonactive]. This book is about learning this.

Also the book of Mantak Chia "Mantak Chia - Taoist Secrets of love - Cultivating male sexual energy.pdf" is an interesting read, and gives insight why Ejaculation even isn't good at all.

I'm hoping to master this myself. Anyone who succeeds at mastering this technique, please post your results regarding the POIS.

If anyone has comments or questions.. Please don't hesitate to ask or say.

Greetz from europe
« Last Edit: 15/05/2008 16:18:44 by jeroboam »

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Offline cdma77

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #517 on: 15/05/2008 17:53:59 »
I just had an idea.  If someone is suffering from nocturnal emissions they may want to try kegal muscle exercises.  It may help, since it helps with PE.  I have had a recent problem with getting a bit of semen coming out once I finish urinating.  It may not be semen but fluid from my prosate since I haven't been having sex or masturbating.  When I loose this fluid I get a lot of the same symptoms as POIS, but not as bad.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #518 on: 15/05/2008 20:09:49 »
TO JEROBOAM

jeroboam, I tried Mantak Chia's techniques on and off for years, with no improvement in POIS. Ejaculation is not the key, it's the orgasm. The orgasm apparently sets off numerous bodily activities that affect POIS directly. I was very disappointed. I even spoke with Mantak Chia and his assistants in Thailand.

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Offline jeroboam

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #519 on: 15/05/2008 22:44:27 »
So you were able to have an orgasm without ejaculation and you'd still have the POIS?

I don't understand, because the link rapidgaming provided stated that with those techniques the dopamine-hangover is avoided...
Or she uses another technique? Does anyone know?


for others that don't know: Kegel-excercises are to strengthen the PC-muscle
« Last Edit: 15/05/2008 22:56:23 by jeroboam »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #520 on: 17/05/2008 03:25:24 »
So you were able to have an orgasm without ejaculation and you'd still have the POIS?

I don't understand, because the link rapidgaming provided stated that with those techniques the dopamine-hangover is avoided...
Or she uses another technique? Does anyone know?


for others that don't know: Kegel-excercises are to strengthen the PC-muscle

Yes, I practiced Mantak Chia's techniques and sucessfully avoided release at orgasm. No effect on POIS. As for the link,  there are as many "theories" as the number of people on the planet. I was very disapointed.

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Offline jeroboam

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #521 on: 17/05/2008 09:54:44 »
So the link off Rapidgaming about the dopamine-hangover... is correct? And this is causing the POIS?

So the techniques they are learning in the book they advertise on the site (book named "peace between the sheets"), is about having sex without having orgasm?
To me that seems the only way to avoid the dopamine-hangover, if what I posted above is all correct.
« Last Edit: 17/05/2008 10:39:13 by jeroboam »

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Offline solution

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #522 on: 18/05/2008 00:59:21 »
What if you can recover quickly that dopamine released? I suppose watching porno movies...or getting very excited again after an orgasm, could be a solution? letīs try...
« Last Edit: 18/05/2008 01:00:59 by solution »

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Offline solution

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #523 on: 19/05/2008 06:02:30 »
...During the "hangover," or "low-dopamine" portion of the cycle, you may feel abandoned, or as if someone is demanding things from you in ways that you cannot tolerate. Or you may desperately seek new highs (alcohol, sweets, new partners, pornography, and so forth) to raise your dopamine levels again...

...Dopamine is behind a lot of the desire we associate with eating and sexual intercourse. Similarly, all addictive drugs trigger dopamine (the "craving neurochemical") to stimulate the pleasure/reward center. So do gambling, shopping, overeating and other, seemingly unrelated, activities. Go shopping: dopamine. Smoke a cigarette: dopamine. Computer games: dopamine. Heroin: dopamine. Orgasm: dopamine. They all work somewhat differently on the brain, but all raise your dopamine.

You get a bigger blast of dopamine eating high-calorie, high-fat foods than eating low-calorie vegetables. You may believe that you love ice cream, but you really love your blast of dopamine. You're genetically programmed to seek out high-calorie foods over others. Similarly, dopamine drives you to have sex over most other activities. With dopamine as the driving force, biology has designed you to engage in fertilization behavior to make more babies, and urges you to move on to new partners to create greater genetic variety among your offspring...




http://www.entelechyjournal.com/pulling_away_after_sex1.htm [nofollow]

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Offline solution

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #524 on: 19/05/2008 06:32:01 »
...Now Apomorphine HCl, a dopamine agonist that stimulates erection, is being approved, and is already for sale in Europe...
...A dopamine agonist drug, therefore, produces effects similar to dopamine in the brain...


Maybe is Levitra acting as dopamine agonist?


http://edlogs.blogspot.com/2007/12/super-size-orgasms.html [nofollow]

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #525 on: 20/05/2008 00:06:47 »
...Now Apomorphine HCl, a dopamine agonist that stimulates erection, is being approved, and is already for sale in Europe...
...A dopamine agonist drug, therefore, produces effects similar to dopamine in the brain...


Maybe is Levitra acting as dopamine agonist?


http://edlogs.blogspot.com/2007/12/super-size-orgasms.html

solution, thank you for that very interesting info. I think B_Jim believes that to be the case, i.e., a Levitra-dopamine connection.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #526 on: 20/05/2008 00:30:51 »

Demografx, I will send you a beginning of letter next week.


Thanks, B_Jim! Meanwile, I have asked The Naked Scientists people here if they can provide any university contacts.

Someone else said they had a contact name or suggestion at Oxford? Please let me know! Thanks.

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Offline Bizzy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #527 on: 20/05/2008 14:35:46 »
If a research team does decide to look into this condition, I wonder how many of you will be willing to travel and participate ??

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Offline pyropeach

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #528 on: 20/05/2008 19:37:30 »
I'd be willing to participate, HANDS DOWN.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #529 on: 20/05/2008 20:56:51 »
If a research team does decide to look into this condition, I wonder how many of you will be willing to travel and participate ??

Interesting, I didn't think of this as personal study, but sure, it could take that route. I see this Forum as a completely democratic process, so you decide. I was thinking we would start by having a research endocrinologist study the hundreds of posts here at POIS Forum and then giving us recommendations as to the next step.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #530 on: 20/05/2008 20:58:08 »
I'd be willing to participate, HANDS DOWN.

Thanks, pyropeach!

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Offline hk1979

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #531 on: 20/05/2008 23:24:23 »
demografx

I think the problem of this research will be that everybody would like to stay anonymous. Even if this eventful discovery of the solution to POIS is groundbreaking, nobody would like to be named as subjects with POIS....

Therefor the endocrinologists should treat all test subjects and control subjects as anonymous.

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Offline hk1979

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #532 on: 21/05/2008 12:44:47 »
solution thanks for the article:

http://edlogs.blogspot.com/2007/12/super-size-orgasms.html [nofollow]

very interesting. the question is how to cut out all the highs of life, and the solution will probably very boring!


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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #533 on: 21/05/2008 19:50:13 »
demografx

I think the problem of this research will be that everybody would like to stay anonymous. Even if this eventful discovery of the solution to POIS is groundbreaking, nobody would like to be named as subjects with POIS....

Therefor the endocrinologists should treat all test subjects and control subjects as anonymous.

Thank you, HK, I agree 100%. As everyone else, I certainly wish to remain anonymous! But I don't think we're anywhere near that point. If anyone thinks differently, please post: I see this first phase simply as a review of all the posts on this POIS Forum, and a recommendation from, an endocrinologist. Then we can decide what we might do next. So, no names needed, just the posted usernames here, but more importantly: the posted information, which contains a wealth of history, experience, solid theories, etc.
« Last Edit: 21/05/2008 20:13:07 by demografx »

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #534 on: 21/05/2008 20:10:49 »
QUESTION, POIS STUDY

Is everyone agreed that the specialist we wish to help us research a cure for POIS is: a research endocrinologist? If anyone disagrees, please post your thoughts within a week, by May 28. Thank you.

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Offline Bizzy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #535 on: 23/05/2008 01:35:13 »
Demografx

This is certainly an endocrinology and neurology area.
The neurological aspect of POIS will be complex and so it would be difficult to persuade a doctor that anything is wrong. A lot of doctors are dismissive and love to cry placebo.
So it is better to take the endocrinology path, which may show hormonal abnormalities.
« Last Edit: 24/05/2008 02:14:47 by Bizzy »

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Offline girlwind

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #536 on: 23/05/2008 18:15:39 »
I can't possibly be the only woman who has this syndrome? I see only men chatting on this website, and in my google search I didn't
find any POIS referring to women. But I must say that it comes as a relief to hear that there is a name for this bizarre post-orgasmic
exhaustion, and that other people are also attempting to find answers and remedies. I have had many of the symptoms described here
after engaging in orgasmic sex--the physical, mental and mood exhaustion, brain fog and flu-like symptoms that last for 3-10 days
after the "event."

For me this all started with a bigger problem back 30 years ago, when I collapsed with Chronic Fatigue Immune Deficiency Syndrome,
(CFIDS) also known as Chronic Fatigue Syndrome. Since then, the fatigue I feel after orgasm has not gone away, despite the fact that
my overall health has generally improved. Some of you have addressed the issue of neurotransmitters, as well as the auto-immune
part of the equation, both of which are KEY factors in dealing with CFIDS, so this is something that I have some experience with.

One thing that has helped me to recover from the overall exhaustion of CFIDS, and to somewhat remedy the orgasmic exhaustion has
been adrenal boosting herbal remedies and vitamins, like Siberian ginseng, schizandra, and large doses of pantothenic acid (up to
5000 mg) in 1000 mg doses, spread out throughout the day with 2000 mg. of Vitamin C per pop. Also important has been managing
stress and avoiding anything close to burn-out, which drains the adrenals and makes the fatigue worse. And getting deep sleep has
been really important too. The amino acid L-Tryptopan has been most beneficial for sleep, and since it is a precursor for serotonin
production, this goes back to the issue of improved neurotransmitter availability in assisting overall recovery from fatigue. Repairing
adrenal exhaustion also has helped my immune system functioning, as there is a direct link between being overly tired/drained and
the tendency to become ill with colds and flus.

But unfortunately, the best remedy has been to omit the orgasm from my sexual repertoire. Which truly sucks. Many women do not
even have orgasms, and so it feels disappointing to forgo what happens naturally for the sake of my overall health. Although I have
noticed over the years, that when I repress the urge to cum for too long, my body will rebel against this eventually and give me an
orgasmic dream in compensation to the enforced repression.

Still, my main question has to do women with this syndrome... How many other woman out there have this?  Is POIS mostly a male
syndrome? Or are many women in the dark about this, as I was, until I found this website?  What are the stats on this? Has anyone
taken the time to do research? And where are they?

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Offline Guthrie

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #537 on: 24/05/2008 03:49:46 »
Hi girlwind,

Yes, it seems that you are the only woman so far on this site who has reported having POIS symptoms.  It is interesting to know that it affects women also--perhaps that can help in figuring out causes/cures.  Since there may be some things that differ between male and female sexual response, the fact that POIS seems to affect both men and women may indicate that with regard to POIS, the causal factor is something common to both male and female orgasm.  For instance, there was some debate in this forum whether orgasm without ejaculation could prevent POIS--but if women get it too, then it probably is something related to orgasm itself, not to ejaculation.

Perhaps other women will write in, now that you have written!

The link to Chronic Fatigue Syndrome is also interesting--perhaps some CFS treatments could work for POIS (although they don't seem to have fully done so in your case).

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Offline Guthrie

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #538 on: 24/05/2008 04:31:40 »
In fact, the list of Chronic Fatigue Syndrome symptoms at this site:
http://www.cfids.org/about-cfids/symptoms.asp
almost make it seem as though POIS could be a 'short-term' or 'specific-occasion-induced' form of CFS.

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #539 on: 24/05/2008 04:38:35 »
In fact, the list of Chronic Fatigue Syndrome symptoms at this site:
http://www.cfids.org/about-cfids/symptoms.asp
almost make it seem as though POIS could be a 'short-term' or 'specific-occasion-induced' form of CFS.

Guthrie, that's exactly what my psychiatrist thought!

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Offline demografx

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #540 on: 24/05/2008 04:57:24 »
WELCOME GIRLWIND!

Since only men have come around, I assumed it was strictly a male problem! Thank you for enlightening us, girlwind.

Guthrie, I agree, now other women can find us and post, too. And as I mentioned earlier, from personal experience, I'm convinced that orgasm, not ejaculation, is the key to POIS.

Girlwind, as you can see from earlier posts, Levitra "cures" 75% of my symptoms, a combination cure of POIS-cycle length and severity. If it's a potential cure, I wonder what that implies for women since it's a male ED drug? Some people here have posted ideas that it's just a part of Levitra that does the trick for POIS. I agree.

I hope you read the posts relevant to our looking for a research endocrinologist to study all the posts here and make some sense of it all. Your input is most welcome. I suspect that somewhere in all the information revealed in this POIS Forum lies a cure for this horrible malady. I think I can safely say "horrible" for all afflicted because it has ruined a chunk of our lives. Even when we are not actively suffering POIS symptoms, they can feel like they're "just around the corner" waiting to happen!

Girlwind, you ask great questions. Almost no research has been done to date. If you Google Marcel Waldinger, a Dutch MD, he is the only published POIS researcher known, and he first described the name Post Orgasmic Illness Syndrome, or POIS. The number of subjects he studied is very small, so this POIS Forum is probably the largest single repository of POIS knowledge!

Girlwind, a question for you: do your orgasmic dreams also create POIS? Welcome again.
« Last Edit: 24/05/2008 05:02:45 by demografx »

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Offline jeroboam

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #541 on: 24/05/2008 18:18:02 »
Have any other persons also noticed the corelation between the quality of the orgasm (the feel good feeling (=amount of dopamine released when orgasming?)) and the bad after-effects? That they are worse when you have a 'better' orgasm?

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Offline girlwind

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #542 on: 24/05/2008 18:59:31 »
Hello guys! It is feels somewhat weird to be the only woman in the discussion so far, but hopefully I will inspire other women to come forward. I actually wrote
one of the Berman sisters a few weeks ago about my symptoms--Jennifer Berman, who is a MD gynecologist in LA specializing in women's sexual issues. When
I described my symptoms to her, she responded in her email back to me that I had "orgasmic disorder," and that I "wasn't alone." But when I looked up orgasmic
disorder, it was all about women who were NOT orgasmic, not about women who had post orgasmic exhaustion. I'm going to email her the link to this discussion
today, so she can get some education about POIS. Unfortunately, in my way-too-long experience with both CFIDS and POIS, medical doctors have too often proven themselves to be over-rated and under-qualified to deal with the mysterious and complex intricacies of the immune and endocrine systems. And after what I have
read here and experienced in my own body, I totally agree that any research about POIS should be focused in large part on the endocrine system. Though I also
think there's a significant link to the immune system, due to the fact that POIS for many of us includes the onset of cold or flu-like symptoms.

Even if my orgasm happens in my sleep, in a dream state which I awaken from mid-orgasm, I experience POIS. However, I have found that those orgasms that
happen spontaneously in a dream state have shorter lasting negative effects than the ones I have "consciously." I've actually kept track of when the dream state
orgasms occur, and over 90% of them have happened mid-cycle, right around the time of ovulation. I've speculated that the exhaustion I feel is less just because
of that. At mid cycle is when progesterone peaks in women... and progesterone is one of the top of the chain steroid hormones. I think this means that I have
enough of an "excess" of steroid hormones to spare at those times, and maybe that's why the POIS symptoms aren't as bad then. Also, because it's the adrenal
cortex that produces the steroid hormones, I think that's why adrenal boosting supplements have helped me to sometimes remedy the POIS symptoms.

demografx: I googled Levitra and read up a bit about it. It's known as a PDE5 inhibitor--does anybody know what that means? I know Levitra increases blood
flow, but HOW exactly it works in the body might be a clue as to why it helps the symptoms of POIS. Because there are some potentially very risky side effects
from taking Levitra, especially prolonged use--like "serious cardiac events" (as in heart attacks), penile tissue damage, and potential loss of vision, due to a
decrease of blood flow to the optic nerve--that isn't something I would want to experiment with. In general I am more inclined to using vitamin supplements,
herbal remedies and hormonal cremes. (I've had far too many side effects and allergic reactions to pharmaceuticals.)  But I'd like to know more details about
how the chemistry of Levitra affects steroid hormone production, or if there is a link along those lines.

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Offline solution

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #543 on: 25/05/2008 08:06:41 »
The process in my view is: orgasm generates something in the brain that generates something in the stomach that generates all ills.
So I think that not finding a remedy for the brain we should tackle the problem in the stomach that produces so many ills

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Offline imre1

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #544 on: 25/05/2008 20:47:59 »
It's been a while since i last posted anything in this thread.

I was just wondering if anybody would be willing to meet other people with this condition in second life?

I would like to create such a place but I have no idea wether people would come.
« Last Edit: 26/05/2008 02:13:40 by imre1 »

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Offline pyropeach

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #545 on: 25/05/2008 20:58:32 »
It's known as a PDE5 inhibitor--does anybody know what that means?

PDE5 is an enzyme that is within the pathway of muscle contraction for smooth muscle tissue.  If this enzyme is inhibited, the smooth muscle cannot contract and remains relaxed causing blood to remain in the penis to prolong erections.  PDE5 is also found in lung tissue.

I was just wondering if anybody would be willing to meet other people with this condition in second life?
 

What do you mean by second life?

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Offline imre1

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #546 on: 26/05/2008 02:13:16 »
What do you mean by second life?

The metaverse: http://secondlife.com/ [nofollow]

Where people can meet almost face to face. In a level that very closely resembles real live communication.

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Offline imre1

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #547 on: 27/05/2008 08:58:47 »
Hi fellow POIS sufferers

Do you folks find that POIS seriously affects every aspect of your life everyday ?.
I find this a very powerful illness which affects me everyday. This is because the mental symptoms linger for so long after an orgasm.


Here is my story thay I recently sent to an emotional support group:

I have had an illness my entire live that makes me allergic to sex. This means that I often have very heavy pain. On top I have fear for everything that has to do with sex and I am often afraid to go to sleep (because of the chance on wet dreams).

For this illnesss there is currently no treatment and I know no doctor who can help me. All doctors that I have visited send me away without answer. Only since shortly I know what is wrong with me. Before that there was only pain, a lot of pain.

On a relational level I can not handle relationships. Because of this illness I am locked up at home and I have a lot of problems to leave home. I have also a lot of fear to handle girls. Therefore I also don't have any friends.

Since shortly I am on second life. I find second life very fun because it allows me to at least virtualy go out.

But when I look around me in second life I see everywhere people that have found other people. This is very hard for me because it reminds me of what I will never have.

I have been in many places in second life and I have met a lot of people. Among which a lot of gay people. Most people have problems with gay people but I find them to be the nicest people.

With my illness I am also a little jealous of them. They at least have people that are like them. Like me there is nobody. I am staying alone and I don't belong anywhere. With hetero people I don't have so much a connection. They are always too much busy with sex.


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Offline chris

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #548 on: 27/05/2008 22:33:15 »
It's been a while since i last posted anything in this thread.

I was just wondering if anybody would be willing to meet other people with this condition in second life?

I would like to create such a place but I have no idea wether people would come.

Why don't you come to the Naked Scientists broadcast in second life on Sunday (10am SL Time / 6pm UK Time) and then you can meet after the show and chat...?
I never forget a face, but in your case I'll make an exception - Groucho Marx

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Offline Bizzy

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Re: Post Orgasmic Illness Syndrome (POIS)
« Reply #549 on: 28/05/2008 02:09:55 »
Imre1 thanks for your previous post. It lets us know that this condition can be part of a greater complex for many POIS sufferers. The greater complex can come in different flavours and some people have it pretty bad.
I think most of us have some core POIS symptoms such as tiredness, brain fog, speech difficulty, depression and flu like symptoms. Some of us have a few odd-ball symptoms as well that noone else seems to have. We can be sure that these are part of POIS too because they happen everytime post orgasm for that person.
« Last Edit: 28/05/2008 02:16:52 by Bizzy »