[Vandemolen3]

Guthrie, you're right, very frustrating that  POIS has so FEW consistencies (none in the lab!?!),  that maybe vitamin D (and anything else that comes up repeatedly) could be worth pursuing.

Thanks to you and anyone else who has pursued this.

Vitamin D could be an idea to collect data. If 50+ members have their Vitamin D checked and all have a low level, then we know we've got something.

[Vandemolen3]

My pituitary scan revealed nothing.

And did you have a scan for de adrenal glands? Sometimes a cyste on another place is responsible for the high cortisol.

My cortisol is normal. I didn't go into more depth as soon as I found dramatic POIS relief with testosterone + stimulants.

Was it only a bloodtest? Or did you do the urine test too?

[Vandemolen3]

Vandemolen, you suggested that I write to Dr Paul Musarella, Netherlands. He wrote back that he's booked till February, 2011, and asks "what would we expect of him?" Do you think he's a good match for us to pursue for POIS research?

I don't know. He was a 'shot in the wild'. He is a commercial doctor. So I doubt that he can be usefull.

[demografx]

Cortisol? Bloodtest. My endo is very skeptical about urine testing.

And again, with such dramatic POIS relief (90% to 95% at first)with testosterone, I saw no point in any further tests.

[Vandemolen3]

I think Tarkington has a long term succes with Relora. I sended him a pm but he doesn't react. Maybe you can send him a mail, Demo. You can see his mailadres:
http://www.thenakedscientists.com/forum/index.php?action=profile;u=8913

Feel free to send him a PM, Vandemolen, it will be sent to his email. We haven't heard from him since January, 2009. Some people reported absolutely no effect with Relora.

But all that proves is that POIS seems to be anything but uniform!

I did. But no response. It could be that he made a mailadres especially for this forum. So did I. Because 2 attempts with my hotmail didn't succed to register. So that's why my nickname is Vandemolen3. I don't check my gmail daily.

[demografx]

I just sent Tarkington an email.

[Vandemolen3]

Cortisol? Bloodtest. My endo is very skeptical about urine testing.

And again, with such dramatic relief with testosterone, I saw no point in any further tests.

That's weird. The best test is 24 hours urine test. First in the morning. Then in the afternoon. Then in the evening. And the last in the morning the next day.
And the best test is the ACTH test (shortage of cortisol, like Addison). And dexamethasone suppression test (too much cortisol, Cushing). Because cortisol and ACTH are related.

[Vandemolen3]

I just sent Tarkington an email.

Thanks! The member Tazzy was also succesfull with Relora. He had only to posts. Maybe you can fwd that mail also to him?

http://www.thenakedscientists.com/forum/index.php?action=profile;u=15017

[demografx]

I'm sending Tazzy an email, but I'm concerned with the quality of his POIS "relief". It seems that he's happy with relief of some symptoms, but not others. Overall, not enough to make him "well." That's my impression, anyway.

He wrote, "Last night I made love to my wife for the first time in 4 weeks and it felt almost as special as our wedding night!

But unfortunately I am experiencing some bad POIS now as this is my first trial with the new drug and having sex.
Although while I'm feeling sick from the orgasms I think the brain fog and anxiety are significantly lower than normal! I believe that Relora or Restoria clam are very effective in helping us!"

[demografx]

Cortisol? Bloodtest. My endo is very skeptical about urine testing.

And again, with such dramatic relief with testosterone, I saw no point in any further tests.

That's weird. The best test is 24 hours urine test. First in the morning. Then in the afternoon. Then in the evening. And the last in the morning the next day.
And the best test is the ACTH test (shortage of cortisol, like Addison). And dexamethasone suppression test (too much cortisol, Cushing). Because cortisol and ACTH are related.

LOL, I will repeat it again, I found no need to delve into further cortisol testing because the testosterone treatment changed my life. Radically!

My POIS was virtually eliminated.

[demografx]

Tarkington also wrote, "I can't be sure that Relora is the cause; It could be a placebo? or even the vitamins I take daily.  All I know is that I DONT feel how I used to after orgasm."

[Vandemolen3]

I'm sending Tazzy an email, but I'm concerned with the quality of his POIS "relief". It seems that he's happy with relief of some symptoms, but not others. Overall, not enough to make him "well." That's my impression, anyway.

He wrote, "Last night I made love to my wife for the first time in 4 weeks and it felt almost as special as our wedding night!

But unfortunately I am experiencing some bad POIS now as this is my first trial with the new drug and having sex.
Although while I'm feeling sick from the orgasms I think the brain fog and anxiety are significantly lower than normal! I believe that Relora or Restoria clam are very effective in helping us!"

Yes that's true. But he had two posts. He was in the beginning fase of Relora. It could be that in the beginning he thought a lot about POIS and that affected how he feeled.

Relora is just a nature medicine. Another medicine that suppresses cortisol would work better.

[Vandemolen3]

Cortisol? Bloodtest. My endo is very skeptical about urine testing.

And again, with such dramatic relief with testosterone, I saw no point in any further tests.

That's weird. The best test is 24 hours urine test. First in the morning. Then in the afternoon. Then in the evening. And the last in the morning the next day.
And the best test is the ACTH test (shortage of cortisol, like Addison). And dexamethasone suppression test (too much cortisol, Cushing). Because cortisol and ACTH are related.

LOL, I will repeat it again, I found no need to delve into further cortisol testing because the testosterone treatment changed my life. Radically!

My POIS was virtually eliminated.

If you feel good now then there is no reason for you to have all kind of tests.

[demografx]

Forum Member "Underwater" replied,

"Tarkington--
Could the plant extracts that constitute Relora serve as a sedative or relaxant that has blunted the "craving" you talk about?  It sounds like the compulsiveness to engage in a certain behaviour significantly diminishes. Could the extracts in Relora act as a type of inhibitory mechanism to balance out whatever may cause compulsive behaviour and the resultant depression. I have a bottle or Relora on my desk, but I have not tried it yet."

 

[demografx]

Relora is just a nature medicine. Another medicine that suppresses cortisol would work better.

Respectfully, I don't think there is any solid evidence that it would work better.

There has been quite a bit of exploration with cortisol and Cushing Syndrome, especially by Counterpoints.

http://www.google.com/#hl=en&rlz=1W1DAUS_en&q=Cushing+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&aqi=&aql=&oq=&gs_rfai=&pbx=1&fp=b18416edbb9fc9c7

http://www.google.com/#hl=en&rlz=1W1DAUS_en&q=cortisol+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&aqi=&aql=&oq=&gs_rfai=&pbx=1&fp=b18416edbb9fc9c7

[pyropeach]

Cortisol? Bloodtest. My endo is very skeptical about urine testing.

And again, with such dramatic relief with testosterone, I saw no point in any further tests.

That's weird. The best test is 24 hours urine test. First in the morning. Then in the afternoon. Then in the evening. And the last in the morning the next day.
And the best test is the ACTH test (shortage of cortisol, like Addison). And dexamethasone suppression test (too much cortisol, Cushing). Because cortisol and ACTH are related.

Something tells me that Cushings isn't something we should be worried with because no body (at least to my knowledge) has complained about high blood pressure.  My blood work didn't show abnormally high cortisol while I was symptomatic.  But don't get me wrong, I think there is high potential for cortisol to be involved in POIS, but probably not severe enough to cause something like Cushings.

[Vandemolen3]

Relora is just a nature medicine. Another medicine that suppresses cortisol would work better.

Respectfully, I don't think there is any solid evidence that it would work better.

There has been quite a bit of exploration with cortisol and Cushing Syndrome, especially by Counterpoints.

http://www.google.com/#hl=en&rlz=1W1DAUS_en&q=Cushing+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&aqi=&aql=&oq=&gs_rfai=&pbx=1&fp=b18416edbb9fc9c7

http://www.google.com/#hl=en&rlz=1W1DAUS_en&q=cortisol+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&aq=f&aqi=&aql=&oq=&gs_rfai=&pbx=1&fp=b18416edbb9fc9c7

I know. But we have to keep searching for something that brings the pain and the fatigue away. If it means Relora works only for 5 or 10 members of us then that's just ok. And others find relief in testosterone patches. Others with nutmeg. We are not doctors. We have to wait for the doctors who hopefully find a cure.

[Vandemolen3]

Cortisol? Bloodtest. My endo is very skeptical about urine testing.

And again, with such dramatic relief with testosterone, I saw no point in any further tests.

That's weird. The best test is 24 hours urine test. First in the morning. Then in the afternoon. Then in the evening. And the last in the morning the next day.
And the best test is the ACTH test (shortage of cortisol, like Addison). And dexamethasone suppression test (too much cortisol, Cushing). Because cortisol and ACTH are related.

Something tells me that Cushings isn't something we should be worried with because no body (at least to my knowledge) has complained about high blood pressure.  My blood work didn't show abnormally high cortisol while I was symptomatic.  But don't get me wrong, I think there is high potential for cortisol to be involved in POIS, but probably not severe enough to cause something like Cushings.

Maybe you are right. The normal doctors and endo's know cortisol from three things: 1. Cushing. 2. Addison. 3. adrenocortical. I think that's the way you can find them listening to you. When the endo discovers that your cortisol level is waving a lot, then he or she will listen to your POIS-theory.

And maybe some of us have both: POIS and Cushing. There some who has POIS and Lymne. And Dave has POIS and Addison.

[Vandemolen3]

I just add the list of sufferers with low Vitamin D level here :
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg201517#msg201517
Guthrie said there are 6 cases, I may forget somebody

--

I can confirm Pyro is right, in my case. I have checked blood pressure just before(140,normal but high limit) and after orgasm (120 : good). And blood pressure didn't increase during flu-like episode.

--

Tarkington have posted this great and hopeful post  :

Hey everyone,
It has been awhile since I last posted. I have been following the forum. I am glad to read that Relora is helping some people.  Just wanted to let everyone know that I have now been taking Relora three times a day since last October. The results have been life changing. I have not had any of the symptoms of POIS since October. I have orgasms everyday and most of the time more than once per day. Everything still seems great.

Thanks!!

 []

Thanks for the list! Guthrie said there were seven cases. I tried to find more who have low Vitamin D but I couldn't find more. Maybe Guthrie knows.

I've read more about Cushing. There is 1 important thing. If you have Cushing that doesn't mean that you have to have a high blood pressure. Cushing CAN lead to a high blood pressure. Cushing CAN lead to diabetes.

Yes that's the post of Tarkington why I am into in the cortisol-theory.

[demografx]

FWIW, I think that my blood pressure is high at POIS onset.