[lauracostis]

^ Great news! One thing. Can you rephrase this?

I need to injest at least 1.5 hours before activity and no longer than 12 hours before, based on limited testing.

RhythmSpring, you need to take the progesterone 1.5 to 2 hours before having sex so that the serum(blood) levels can reach there peak levels. also he is saying that taking it 12 hours before is to long of a peroid to wait before having sex, because the high levels of progesterone will be all used up by then.

[lauracostis]

limejuice have you had to continually take the progesterone through the next following days to keep the pois at bay.

[lauracostis]

i looked up the peak blood level for oral progesterone in my drug guide and blood levels peak approximately 2-4 hours after ingestion.

[daveman]

LJ, sorry for the question, but what approach to the "O" are you using? NE, masturbation or partner?

[pyropeach]

Just an update, I'm continuing to have sucess with progesterone. I've experiemented and have found a correlation where the more progesterone I take the better I feel after O. I've never like giving figures like a percentage cured, but to scale the results 15mg equals about a 90% cure. I need to injest at least 1.5 hours before activity and no longer than 12 hours before, based on limited testing.

Sounds like something that needs to be added to the compendium!

[demografx]

Housekeeping: how does one go to a certain page on this forum?  Thank you.

The only way I know is to click down 2 pages at a time from the pagelist at the top or bottom. But if you can get the post's link (via Google), it will take you directly to that page.

[demografx]

LJ, sorry for the question, but what approach to the "O" are you using? NE, masturbation or partner?

daveman, I know you didn't ask me, but I just wanted to interject that I don't think we've ever seen a distinction here in POIS effects based on "approach".

[demografx]

Could anybody provide us with information on the compounds of prostate fluid? I think that in some cases the cause of POIS is recovering of prostate fluid after ejaculation that depletes some vital substance and leads to POIS.

I've always felt that sperm regeneration time is somehow implicated. With my testosterone treatment, I can feel that my regeneration is now much, much faster than before.

[demografx]

Progesterone

I asked my pharmacology-attorney friend with a major government state agency about progesterone. His reply:

" [Demo], I'd be real careful using progesterone. See below. "

             

                   Progesterone Side Effects

Brand Names: Crinone, Endometrin, Prochieve, Prometrium

Please note - some side effects for Progesterone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Progesterone - for the Consumer
Progesterone

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Progesterone:

Bloating; breast tenderness; diarrhea; dizziness; drowsiness; dry mouth; fluid retention; headache; heartburn; irritability; muscle pain; nausea; stomach pain or cramping; tiredness; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur when using Progesterone:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; bulging eyes; coughing up blood; dark urine; double vision; fainting; gallstones; mental or mood changes (eg, depression or worry); migraine; numbness of an arm or leg; pain or lumps in the breast; one-sided weakness; pounding in the chest; seizures or tremors; severe stomach pain; speech problems; stomach pain, swelling, or tenderness; sudden, severe chest pain or numbness; sudden, severe headache; sudden, severe vomiting, dizziness, or fainting; sudden sharp pain or swelling in the calf or leg; sudden shortness of breath; swelling of the ankles or fingers; vision problems or changes (including sudden, partial, or full loss of vision); yellowing of the eyes or skin.
Progesterone Gel
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Progesterone Gel:

Breast enlargement; breast pain; changes in sex drive; constipation; cramps; depression; diarrhea; difficult or painful sexual intercourse; drowsiness; fatigue; fluid retention/bloating; headache; increased appetite; joint pain; nausea; nervousness; pain around vaginal area; sleep disorder; urination at night; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur when using Progesterone Gel:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; breast lumps; calf/leg pain or tenderness; change in emotions, mood, or behavior; chest pain; coughing blood; dizziness; fainting; inflammation of the eye; numbness of arm or leg; one-sided weakness; pain in the groin; partial or complete loss of vision; seizure; stomach pain, swelling, or tenderness; sudden, severe headache, vomiting, dizziness, or fainting; sudden shortness of breath; swelling of hands, ankles, or feet; tremor; unusual vaginal discharge or odor; vaginal itching; visual or speech disturbances; weakness or numbness in an arm or leg; yellowing of the skin or eyes.
Progesterone Insert
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Progesterone Insert:

Bloating; breast tenderness; constipation; cramping; drowsiness; fluid retention; headache; nausea; stomach pain; tiredness; vaginal burning or irritation; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur when using Progesterone Insert:
Severe allergic reactions (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; calf or leg pain, swelling, or tenderness; change in emotions, mood, or behavior; chest pain; coughing up blood; fainting; one-sided weakness; pain in the groin; partial or complete loss of vision; stomach pain, swelling, or tenderness; sudden, severe headache, vomiting, dizziness, or fainting; sudden shortness of breath; swelling of hands, ankles, or feet; unusual vaginal itching, discharge, or odor; visual or speech disturbances; weakness or numbness in an arm or leg; yellowing of the skin or eyes.
Progesterone Oil
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Progesterone Oil:

Acne; drowsiness; nausea; pain, redness, and swelling at injection site; trouble sleeping; weakness.
Seek medical attention right away if any of these SEVERE side effects occur when using Progesterone Oil:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); breast pain or tenderness; calf or leg pain or swelling; changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; chest pain; coughing up blood; fast or irregular heartbeat; fever; flushing; lumps in the breast; mental or mood changes (eg, anxiety, depression); seizures; severe dizziness or fainting; severe stomach pain; shortness of breath; slurred speech; sudden loss of coordination; sudden or severe headache or vomiting; swelling of fingers or ankles; unusual weight gain or loss; vision problems (eg, double vision, partial or complete loss of vision); weakness, numbness, or pain in the arms or legs; yellowing of the skin or eyes.
Top
Side Effects by Body System
Genitourinary
Genitourinary side effects have included breast tenderness (27%), urinary problems (11%), vaginal discharge (10%), vaginal dryness (6%), breast pain (6%), breast carcinoma (2%), breast excisional biopsy (2%), breast enlargement, leukorrhea, uterine fibroid, vaginal dryness, fungal vaginitis, vaginitis, dysuria, cystitis, and urinary tract infection

Nervous system

Nervous system side effects have included headache (31%), dizziness (15%), confusion, somnolence, asthenia, increased sweating, nervousness, migraine, tremor, and speech disorder. Syncope (with and without hypotension) have been reported.

Cardiovascular

Cardiovascular side effects have included chest pain (7%), hypertension, angina pectoris, syncope, and palpitations.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain (20%), bloating (8%), diarrhea (8%), nausea (8%), constipation (3%), dyspepsia, dry mouth, gastroenteritis, hemorrhagic rectum, hiatus hernia, and vomiting. The side effects reported during clinical studies evaluating the use of progesterone gel 8% have included constipation (27%), nausea (22%), and diarrhea (8%).

Musculoskeletal

Musculoskeletal side effects have included joint pain (20%), musculoskeletal pain (12%), back pain (8%), arthritis, leg cramps, hypertonia, muscle disorder, and myalgia.

Psychiatric

Psychiatric side effects have included depression (19%), anxiety, impaired concentration, insomnia, forgetfulness, and personality disorder.

Respiratory

Respiratory side effects have included cough (8%), bronchitis, nasal congestion, pharyngitis, pneumonitis, and sinusitis.

Dermatologic

Dermatologic side effects have included acne, pruritus, rash, skin discoloration, seborrhea, verruca, and wound debridement during therapy.

Additional dermatologic side effects have included case reports of familial autoimmune dermatitis.

Ocular

Ocular side effects have included abnormal vision.

Hepatic

Hepatic side effects including reversible cases of hepatitis, elevated transaminases, and cholecystectomy have been reported.

Other

Other side effects have included viral infection (12%), hot flashes (11%), fatigue (8%), irritability (8%), worry (8%), night sweats (7%), earache, tooth disorder, anorexia, increased appetite, peripheral edema, edema, accidental injury, fever, abscess, lymphadenopathy, and herpes simplex.

Immunologic

Immunologic side effects have included autoimmune dermatitis during the luteal phase of the menstrual cycle. Test results using interferon gamma release in vivo and vitro tests confirmed the diagnosis.

Local

Local side effects have included pain, irritation, and redness at the injection site.

Top
More Progesterone resources

Progesterone MedFacts Consumer Leaflet (Wolters Kluwer)
Progesterone Prescribing Information (FDA)
Progesterone Professional Patient Advice (Wolters Kluwer)
Progesterone Detailed Consumer Information (PDR)
Crinone Prescribing Information (FDA)
Crinone Advanced Consumer (Micromedex) - Includes Dosage Information
Crinone Gel MedFacts Consumer Leaflet (Wolters Kluwer)
Endometrin Prescribing Information (FDA)
Endometrin Insert MedFacts Consumer Leaflet (Wolters Kluwer)
Endometrin Consumer Overview
Prochieve Prescribing Information (FDA)
Prochieve Detailed Consumer Information (PDR)
Prochieve Gel MedFacts Consumer Leaflet (Wolters Kluwer)
Prometrium Prescribing Information (FDA)
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.


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[Limejuice]

lauracostis is correct with the rephrase. 

^ Great news! One thing. Can you rephrase this?

I need to injest at least 1.5 hours before activity and no longer than 12 hours before, based on limited testing.

[Limejuice]

Testing has been limited but so far the one time dose is enough. 

limejuice have you had to continually take the progesterone through the next following days to keep the pois at bay.

[Limejuice]

Partner. 

LJ, sorry for the question, but what approach to the "O" are you using? NE, masturbation or partner?

[Limejuice]

It's still early with testing and I'd hate to post a placebo in the compendium but hopefully as time goes on we may have another symptom reducer.

Just an update, I'm continuing to have sucess with progesterone. I've experiemented and have found a correlation where the more progesterone I take the better I feel after O. I've never like giving figures like a percentage cured, but to scale the results 15mg equals about a 90% cure. I need to injest at least 1.5 hours before activity and no longer than 12 hours before, based on limited testing.

Sounds like something that needs to be added to the compendium!

[Limejuice]

Thanks for the warnings Demo.  I'm concerned myself for the dosage I take and the unknown testing on males.

Sorry I posted so many replies.  I'd like to reduce spam and use one post for all.

[CertainlyPOIS]

placebo or no placebo i am beyond excited.   
I was just wondering lime juice, how long does it take you to recover fromm pois.
Thanks for taking the risk and continuall testing.

[Limejuice]

I've always had a continuous POIS hangover sometimes lasting months.  I definately feel that still.  But the brute POIS symptoms are real mild now - those are cognative symptom for me.  I really need more testing because it's only been a week plus for this new trial.

[daveman]

LJ, sorry for the question, but what approach to the "O" are you using? NE, masturbation or partner?

daveman, I know you didn't ask me, but I just wanted to interject that I don't think we've ever seen a distinction here in POIS effects based on "approach".

It's that some have said that the effects have seemed worse with just masturbation, where a partner is not involved.

That also added to the potential for there being a positive effect associated to one mechanism or other when the "O" is associated to sex with a partner. (absorbtion of hormones such as progesterone or effects of pheromones)

[daveman]

Itsmebutwho?

You had POIS before?

[demografx]

I feel usually great after masturbated [sic] (****** with an artificial vagina) in dark room

Convince us that you are here to post your thoughts on a science forum and not in a sleazy, street-corner porn competition for school dropouts, and you can re-post your adult thoughts clearly, keeping in mind that schoolchildren also visit the science forum and may wander here. Yes, this is a warning. Thank you very much for cooperating.

[also sent via Private Message]

[demografx]

Thanks for the warnings Demo.  I'm concerned myself for the dosage I take and the unknown testing on males.

Sorry I posted so many replies.  I'd like to reduce spam and use one post for all.

You're very welcome. I didn't want to overdo it with the cautionary stuff, but my friend sent me all of that and I didn't know where to cut.

No problem with the multi-posting, Limejuice, this is an important event!