[Green]

Getting close to a million views on this thread!

[Animus]

That is so fantastic. Sounds like your best results were done the first way, and you're going to repeat that again. Was there any problem with the Silodosin, or could you tolerate it pretty well? Any negative side effects?

The main side-effect was that I was extremely sleepy for several days, rather inconveniently for me. Not POIS sleepy, just sleepy. However, my subsequent doses of Silodosin only made me feel moderately sleepy - another poster suggested that this is a common side-effect with alpha-blockers that would disappear after a couple of weeks.

If it turns out that I'm just swapping one problem for another, I may have to ultimately abandon Silodosin, but I will keep trying for now. Time will tell.

Yeah, I think you should stay with it. You might be onto something major with this. don't give up. I mean, there are lots of people who would trade some drowsiness for their full POIS symptoms. And the drowsiness could be temporary.
Now, is this Silodosin something you need a prescription for? And is it priced reasonably?

[scooby]

Hi all,
I also suffer from POIS. I have done since i was 18, im now 35. I thought i was the only person with this condition.
Whenever i orgasm or even aroused now i feel so ill afterwards for like 2 weeks, mental and physical symptoms. I already suffer from depression so it is really hard.

In the last 2 years i have abstained from orgasm but i still have symptoms if ever i get sexually aroused. Its just killed my sexual instinct. I personally think we have some sort of auto-immune reaction. I have heard low dose naltroxene is good for these conditions. Has anyone tried it?

[Guthrie]

Over 1,000,000 views!!!!

[Guthrie]

If it turns out that I'm just swapping one problem for another, I may have to ultimately abandon Silodosin, but I will keep trying for now. Time will tell.

Yeah, I think you should stay with it. You might be onto something major with this. don't give up. I mean, there are lots of people who would trade some drowsiness for their full POIS symptoms. And the drowsiness could be temporary.

Yes, I agree--it could prove an important result.  That is, if silodosin can prevent POIS by preventing ejaculation, then even if you decide that the side effects are too burdensome, we'll at least have learned that POIS is caused specifically by ejaculation, and not by orgasm per se!

[demografx]

Over 1,000,000 views!!!!

Thanks for posting, Guthrie!

[demografx]

If it turns out that I'm just swapping one problem for another, I may have to ultimately abandon Silodosin, but I will keep trying for now. Time will tell.

Yeah, I think you should stay with it. You might be onto something major with this. don't give up. I mean, there are lots of people who would trade some drowsiness for their full POIS symptoms. And the drowsiness could be temporary.

Yes, I agree--it could prove an important result.  That is, if silodosin can prevent POIS by preventing ejaculation, then even if you decide that the side effects are too burdensome, we'll at least have learned that POIS is caused specifically by ejaculation, and not by orgasm per se!

Guthrie, excellent point.

[Animus]

If it turns out that I'm just swapping one problem for another, I may have to ultimately abandon Silodosin, but I will keep trying for now. Time will tell.

Yeah, I think you should stay with it. You might be onto something major with this. don't give up. I mean, there are lots of people who would trade some drowsiness for their full POIS symptoms. And the drowsiness could be temporary.

Yes, I agree--it could prove an important result.  That is, if silodosin can prevent POIS by preventing ejaculation, then even if you decide that the side effects are too burdensome, we'll at least have learned that POIS is caused specifically by ejaculation, and not by orgasm per se!

It's already been confirmed by Waldinger that POIS is caused by ejaculation- at least that seems to be the hypothesis he's going on.
The benefit of this could be a much faster remedy for those who suffer with POIS instead of waiting years for the desensitization treatment. Perhaps the both could be done in tandem.

[demografx]

Animus, very good and flexible point you make. And as Dr Waldinger pointed out to me, testosterone treatment success is not incompatible with his findings. Plenty of room for many many new possibilities, which to me is very exciting.

[Guthrie]

we'll at least have learned that POIS is caused specifically by ejaculation, and not by orgasm per se!

It's already been confirmed by Waldinger that POIS is caused by ejaculation- at least that seems to be the hypothesis he's going on.
The benefit of this could be a much faster remedy for those who suffer with POIS instead of waiting years for the desensitization treatment. Perhaps the both could be done in tandem.

Yes, Dr. Waldinger's hypothesis is that it POIS is caused by ejaculation.  However, as far as I know, he hasn't worked on separating orgasm from ejaculation.  If, through silodosin, we can link POIS specifically to ejaculation, and not orgasm, it can lend further weight to his hypothesis.

Also, it would be another nail in the coffin of the 'pyscho-sexual' accusation, since this could show that one can engage in a full act of sexual release, including orgasm, yet with no POIS--but when you add in the semen, that's when the POIS kicks in!

[demografx]

I have heard low dose naltroxene [sic] is good for these conditions. Has anyone tried it?

Perhaps some previous discussions here about naltrexone can help:
http://www.google.com/search?q=naltroxene+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&sourceid=ie7&rls=com.microsoft:en-us:IE-SearchBox&ie=&oe=#hl=en&rls=com.microsoft:en-us:IE-SearchBox&&sa=X&ei=21hsTdP2KpDSsAPs5N3LAw&ved=0CBgQvwUoAQ&q=naltrexone+POIS+site%3Ahttp%3A//thenakedscientists.com&spell=1&bav=on.1,or.&fp=42ea6e12edc6080

[CertainlyPOIS]

I have heard low dose naltroxene [sic] is good for these conditions. Has anyone tried it?

Perhaps some previous discussions here about naltrexone can help:
http://www.google.com/search?q=naltroxene+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&sourceid=ie7&rls=com.microsoft:en-us:IE-SearchBox&ie=&oe=#hl=en&rls=com.microsoft:en-us:IE-SearchBox&&sa=X&ei=21hsTdP2KpDSsAPs5N3LAw&ved=0CBgQvwUoAQ&q=naltrexone+POIS+site%3Ahttp%3A//thenakedscientists.com&spell=1&bav=on.1,or.&fp=42ea6e12edc6080

if you are interested in trying it, pm me i have list of doctors that prescribe over phone.
speaking of ldn, lauracostisis do you still use it.

[phill101]

I've also started taking prozac and have been on it for about a week now for anxiety and depression, but I've had a slight hope that it will decrease my libido as well. Perhaps someone else here has noticed a decrease in libido from prozac or some other similar medication?

Peroxatine (seroxat) is an anti-depressant  I took for several years and it definitely reduced my Libido. However, I wouldnt suggest taking this drug for reducing your Libido. The reason I say this is that there are other side effects associated with Peroxatine which arent too pleasant and withdrawl is truly harrowing, trust me on this one! You might want to check wikipedia for further info on this drug.

[demografx]

scooby, and phill101, welcome to the POIS thread of The Naked Science Forum!




Here are some POIS resources which may be helpful to you:


Our POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/POISwebsite/

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:

Our new POIS chatroom (realtime chat). Invite or visit another member(s) there, ANY TIME. We can all get to know each other better:
http://forums.delphiforums.com/POIS/chat


* Most recent POIS Research Studies, 2011 *

If you will send Prof. dr. Waldinger an e-mail, stating that you have read his message on the Forum, at http://www.thenakedscientists.com/forum/index.php?topic=6576.msg340138#msg340138 and that you are willing to fill in a questionnaire, he will send you the copies of both 2011 research articles by return through email. At a later date, he will send you the questionnaire which, after having filled in, you should send him back by e-mail.
His email:
prof.dr.waldinger.pois@gmail.com

Prof. dr. Marcel D. Waldinger's website:
http://www.post-orgasmic-illness-syndrome.com/en/index.html


First POIS Research Study, 2002

We have a copy of the first formal medical investigation on POIS by Prof. dr. Marcel D. Waldinger,MD,PhD, and Dr. Dave Schweitzer, MD.

  
Recent POIS Research Study, 2010

CASE REPORT
Postorgasm Illness Syndrome - A Spectrum of Illnesses
Jane Ashby, MRCP, and David Goldmeier, MRCP
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg316781#msg316781


British Medical Journal Case Report, 2010

Case study by Dr. Selwyn Dexter of a patient with a headache-featured POIS symptom treated with progesterone/norethisterone.
http://casereports.bmj.com/content/2010/bcr.10.2009.2359.short?rss=1


There are a couple of ways to get any or all of the above 3 studies: (1) if you want a PDF copy, send me a Private Message (PM) with your regular email address (use "AT" instead of "@" ) and I'll send you back the PDF.

Or, if you prefer, (2) I can simply reply with a Private Message (no regular email needed) and provide you with a simple text version embedded in your PM.

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around my name, i.e., "demografx".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show our credibility to the medical world - which often shows little understanding and is sometimes skeptical of our condition: POIS has scientific underpinnings and POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapeutic community. All of this information can greatly help you to fight the immediate reaction of some doctors: so just tell them, "IT'S NOT 'ALL IN OUR HEADS'! "

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum, which has already been referenced in respectable sources such as the Journal of Sexual Medicine (Dr. Waldinger's study), British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For over 4 years, our POIS forum has attracted over 200 POIS sufferers worldwide who have posted here, research on an additional 200 sufferers elsewhere on the internet, plus over 1,000,000 page visits. Not bad for a rare malady!

[demografx]

scooby, and phill101, this post will help you find information about POIS that we have already discussed, by tailoring a Google search to this forum:


SEARCH THE FORUM WITH GOOGLE

We have an overwhelming amount of data: almost 4 years' worth of posts (over  10,000 posts!) from 150+ Forum members, and an additional 150 POIS sufferers found elsewhere on the Internet by Member B_Jim.

In the Google search box, type
whatever-it-is-you're-interested-in-finding-out[space]POIS[space]site:http://thenakedscientists.com/

for example, I tried
nocturnal emission POIS site:http://thenakedscientists.com/

and 740 results came up for "nocturnal emission" within the Forum.

be careful with spaces (you can use them before the word "site") and no-spaces (everything after the word "site")

Google even provides you results with the Message# for each result. But Message #'s do change, so be patient and look for the approximate Message#.

[demografx]

Amazing number of 1 000 000 views. I remember we started with 2000 views a month...

Yes, B_Jim. And half of those views were you and me checking and re-checking our posts for accuracy!  []

[Defsync]

If it turns out that I'm just swapping one problem for another, I may have to ultimately abandon Silodosin, but I will keep trying for now. Time will tell.

Yeah, I think you should stay with it. You might be onto something major with this. don't give up. I mean, there are lots of people who would trade some drowsiness for their full POIS symptoms. And the drowsiness could be temporary.

Yes, I agree--it could prove an important result.  That is, if silodosin can prevent POIS by preventing ejaculation, then even if you decide that the side effects are too burdensome, we'll at least have learned that POIS is caused specifically by ejaculation, and not by orgasm per se!

It's already been confirmed by Waldinger that POIS is caused by ejaculation- at least that seems to be the hypothesis he's going on.
The benefit of this could be a much faster remedy for those who suffer with POIS instead of waiting years for the desensitization treatment. Perhaps the both could be done in tandem.

This is what Waldinger says and it bothers me. I can produce POIS symptoms with absolutely no ejaculation of any kind of fluid of any kind. I believe it is the chemical that causes the contraction of the muscles, OR the chemical that causes the RELEASE of this chemical, that I believe is that cause of POIS, the chemical that causes that "feel good" feeling contraction.

[Defsync]

I have heard low dose naltroxene [sic] is good for these conditions. Has anyone tried it?

Perhaps some previous discussions here about naltrexone can help:
http://www.google.com/search?q=naltroxene+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&sourceid=ie7&rls=com.microsoft:en-us:IE-SearchBox&ie=&oe=#hl=en&rls=com.microsoft:en-us:IE-SearchBox&&sa=X&ei=21hsTdP2KpDSsAPs5N3LAw&ved=0CBgQvwUoAQ&q=naltrexone+POIS+site%3Ahttp%3A//thenakedscientists.com&spell=1&bav=on.1,or.&fp=42ea6e12edc6080

naltrexone did nothing for me

[Defsync]

http://en.wikipedia.org/wiki/Cytokine_storm

I am interested in whether cytokine blocking / counteracting agents may help with POIS. Side-note: mast cells release cytokines along with histamine.

http://en.wikipedia.org/wiki/TNF_inhibitor

Focalin has been researched to provide relief for people with chemo brain, which is a condition similar to POIS (the mental dysfunction side).

http://en.wikipedia.org/wiki/Dexmethylphenidate

Gemfibrozil

This is a drug that has shown in mice to have anti-cytokine properties. Nice thing about this one is it is already approved for human use, for cholesterol.

http://en.wikipedia.org/wiki/Gemfibrozil

[Counterpoints]

I have heard low dose naltroxene [sic] is good for these conditions. Has anyone tried it?

Perhaps some previous discussions here about naltrexone can help:
http://www.google.com/search?q=naltroxene+POIS+site%3Ahttp%3A%2F%2Fthenakedscientists.com&sourceid=ie7&rls=com.microsoft:en-us:IE-SearchBox&ie=&oe=#hl=en&rls=com.microsoft:en-us:IE-SearchBox&&sa=X&ei=21hsTdP2KpDSsAPs5N3LAw&ved=0CBgQvwUoAQ&q=naltrexone+POIS+site%3Ahttp%3A//thenakedscientists.com&spell=1&bav=on.1,or.&fp=42ea6e12edc6080

naltrexone did nothing for me

regular dose naltrexone (50 mg/day) helped me somewhat.