[Guthrie]

http://myhealth.hollandhospital.org/HealthTopics/allergies/dec07acMain.htm

Dr. Ronald Simon, an allergist at Scripps Clinic in San Diego , told HealthDay that he and his colleagues have treated patients with a mixture of contraceptive gel and an anti-allergy medication, cromolyn.

Thanks Horizon, I'll be contacting Dr. Ronald. 

It mentions the potential for a prostatic protein (part of the semen one would imagine) being a guilty culprit as well as sperm.

Hmmm, it the 'guilty culprits' are said to include fluids beyond sperm itself, this could potentially account for why some men suffer POIS simply from arousal and pre-ejaculate fluid without ejaculation.

[horizon]

Can someone tell me what the link or difference is between the existing Antisperm Antibodies test and what we talking about in relation to 'allergy to sperm'?
thanks

http://www.medichecks.com/tests/blood_tests/test.cfm?test=ASAB&name=Antisperm+Antibodies
http://www.nuh.nhs.uk/andrology/Antisperm_Antibodies.aspx

[demografx]

My opinion of Yahoo Answers just changed (not for the better!)
From http://answers.yahoo.com/question/index?qid=20110430211745AAv7oKm

Resolved Question: Post Orgasm Illness Syndrome (POIS)?

Is it usual to feel really exhausted and even depressed weeks after sex? I read about something called POIS, and I'm just wondering if it's normal to experience this...

Asked by  Sun 16 hours ago Report Abuse

Best Answer:

Feeling really exhausted is supposed to be a good feeling that lasts for a few minutes after sex. If you feel exhausted and depressed for weeks after the sex, sex is not the problem! See a shrink for your mental health!

Answer by  NickP 16 hours ago Report Abuse
Asker's Rating:

Thanks

edit -  To NickP:

Nick, we here at the POIS Forums owe you a major debt of gratitude. How foolish of us and all the POIS medical researchers all these years to think that POIS could be caused by autoimmune, hormonal, spermatalogical, or other physiological  disorders!!! []

[demografx]

dan-ireland, this post will help you find information about POIS that we have already discussed, by tailoring a Google search to this forum:

Thanks very much Demo, and thanks for the welcome, hope I can make a difference

You already have!  []

[Vincent M]

demo, I was banned from yahoo answers from spreading too much information about POIS lol. I guess they thought I was a spammer. I'll try to get my account back eventually and I'll try to be more selective of who I try to spread awareness to in the future.

[Finally]

My opinion of Yahoo Answers just changed (not for the better!)
From http://answers.yahoo.com/question/index?qid=20110430211745AAv7oKm

Resolved Question: Post Orgasm Illness Syndrome (POIS)?

Is it usual to feel really exhausted and even depressed weeks after sex? I read about something called POIS, and I'm just wondering if it's normal to experience this...

Asked by  Sun 16 hours ago Report Abuse

Best Answer:

Feeling really exhausted is supposed to be a good feeling that lasts for a few minutes after sex. If you feel exhausted and depressed for weeks after the sex, sex is not the problem! See a shrink for your mental health!

Answer by  NickP 16 hours ago Report Abuse
Asker's Rating:

Thanks

edit -  To NickP:

[]

Thanks Nick. We're all crazy. We can close the forum now.
And yes I would like fries with that.

[monkeyboy]

Hey guys I've had an interesting development about two weeks ago I was in the gym at my college working out with some ex-marines. I train with these guys 2-3 hours a day and do gymnastic level excercises. Getting to the point one of them gives me two packets of pills. One is called rocket fuel and the other is called animal cuts. Both are herbal based adrenaline and caffine boosters for increased metabolic rate and pain tolerance basically it makes you invincible for 12 hours so you can do extreme training you couldn't otherwise handle. After taking that stuff my pois symptoms have reduced by a good 60-70% and have not returned back to as they were. Anyone want to take a guess as to why this has happend? Don't try this yourself if you aren't a good athlete it will put you in the hospital if you don't keep yourself hydrated properly and monitor your heart rate.

[demografx]

demo, I was banned from yahoo answers from spreading too much information about POIS lol. I guess they thought I was a spammer. I'll try to get my account back eventually and I'll try to be more selective of who I try to spread awareness to in the future.

VM, thanks for doing that!

Yeah, we would do the same here if someone promoted another site. And I was banned like you too for trying to promote us elsewhere.

Next time, just be more cautious by being vague about "this place" - talk about "POIS-sufferer-communities", and be less direct about our group here. Let them PM you on their own initiative  instead - - so they can take the step themselves to  find out how you were able to accomplish your advanced understanding of POIS.

[Animus]

Hey guys I've had an interesting development about two weeks ago I was in the gym at my college working out with some ex-marines. I train with these guys 2-3 hours a day and do gymnastic level excercises. Getting to the point one of them gives me two packets of pills. One is called rocket fuel and the other is called animal cuts. Both are herbal based adrenaline and caffine boosters for increased metabolic rate and pain tolerance basically it makes you invincible for 12 hours so you can do extreme training you couldn't otherwise handle. After taking that stuff my pois symptoms have reduced by a good 60-70% and have not returned back to as they were. Anyone want to take a guess as to why this has happend? Don't try this yourself if you aren't a good athlete it will put you in the hospital if you don't keep yourself hydrated properly and monitor your heart rate.

Hi Monkey-boy, Thanks for sharing your input. I feel I should add that Herbal- based "enhancement" pills can be VERY dangerous. They aren't regulated or tested, and can have devastating effects on the body especially if taken over time. I developed a very Severe case of POIS after taking Herbal Male Enhancement pills for 2 months which were designed to enlarge the sex organs. I suffered for many years because of that bad decision. The enlargement pills wreaked havoc on me!

I realize you're talking about a different Herbal product, but I would be extremely careful about recommending this. As you yourself have done. Please be careful with this stuff.

[demografx]

Hey guys I've had an interesting development about two weeks ago I was in the gym at my college working out with some ex-marines. I train with these guys 2-3 hours a day and do gymnastic level excercises. Getting to the point one of them gives me two packets of pills. One is called rocket fuel and the other is called animal cuts. Both are herbal based adrenaline and caffine boosters for increased metabolic rate and pain tolerance basically it makes you invincible for 12 hours so you can do extreme training you couldn't otherwise handle. After taking that stuff my pois symptoms have reduced by a good 60-70% and have not returned back to as they were. Anyone want to take a guess as to why this has happend? Don't try this yourself if you aren't a good athlete it will put you in the hospital if you don't keep yourself hydrated properly and monitor your heart rate.

Thanks for the caveats.

A few bodybuilders at our forum tend to be a nuisance (not you!  -  I refer to "the preachers" who come here to 'show us stupid people how it's done'). Some have  claimed to "cure POIS" by inhaling the entire contents of a health food/nutrition store (exaggerated for highlighting my point).

They tend to take dangerous, supraphysiologic doses of steroids, including testosterone.

High dose stimulants like you describe can work at first, but eventually will drain your energy and POIS will be even worse. Uncontrolled tolerance will require ever larger doses to achieve the same effect you had initially.

I am on endocrinologically and medically  monitored doses of testosterone and LOW-DOSE stimulants and they work great now for over 2 years for me. But I've done that with a great deal of careful medical supervision and repeated bloodtesting of hormones and many other body functions, including brain scans - to make sure that the cure won't kill me!

For those with dopamine-deficiency-related POIS, cocaine might also work short term, according to my psychiatrist friend.

But we all know where THAT drug usage eventually winds up. Hint: there are very, very few - if any - longterm cocaine users with smooth sailing in terms of their mental, physical, and emotional health.

Best wishes to you going forward!! Thanks much for sharing your experience!

[lauracostis]

Hey guys I've had an interesting development about two weeks ago I was in the gym at my college working out with some ex-marines. I train with these guys 2-3 hours a day and do gymnastic level excercises. Getting to the point one of them gives me two packets of pills. One is called rocket fuel and the other is called animal cuts. Both are herbal based adrenaline and caffine boosters for increased metabolic rate and pain tolerance basically it makes you invincible for 12 hours so you can do extreme training you couldn't otherwise handle. After taking that stuff my pois symptoms have reduced by a good 60-70% and have not returned back to as they were. Anyone want to take a guess as to why this has happend? Don't try this yourself if you aren't a good athlete it will put you in the hospital if you don't keep yourself hydrated properly and monitor your heart rate.

The "Rocket Fuel" sounds tempting, but taking"Animal Cuts", I would really have to think about that for a long while

[lauracostis]

I had something important to say, but I forgot; If I was a bodybuilder, I actually do not think I could resist buying a package on the shelf that was labeled "Animal Cuts". I advise any individual not to feed there children "Animal Cuts", not before noon at least.

post script: sorry to the original poster(monkeyboy), I had to talk about "Animal Cuts"

[monkeyboy]

lol thats all good guys taking the combo of rocket fuel and animal cuts at the same time was increadibly stupid on my part the marine who takes them is 200 some odd pounds 13% body fat I'm 125lbs 4% body fat so it was about twice as powerful on me as on him so I ended up wired as hell all the way into the next morning doing pushups situps and whatever I could possibly do to try to make myself tired but it wasnt working. The hangover was brutal I about couldn't walk after so many hours of training it lol. I was fortunate a stupid decision worked out for the best it had some kind of positive effect either on my thyroid or adrenal glands that some how made me a lot better it's not just phychosomatic I can tell that there has been a dramatic change in my pois condition. I wouldn't recommend trying this if you didn't have someone with you who has athletic/nursing/medical knowlege with you for your own safety. Granted everyone is different so it's hard to say if you would have the same result but I'm grateful as hell to have over 60% of my pois symptom reduced.

[Finally]

Hey guys I've had an interesting development about two weeks ago I was in the gym at my college working out with some ex-marines. I train with these guys 2-3 hours a day and do gymnastic level excercises. Getting to the point one of them gives me two packets of pills. One is called rocket fuel and the other is called animal cuts. Both are herbal based adrenaline and caffeine boosters for increased metabolic rate and pain tolerance basically it makes you invincible for 12 hours so you can do extreme training you couldn't otherwise handle. After taking that stuff my pois symptoms have reduced by a good 60-70% and have not returned back to as they were. Anyone want to take a guess as to why this has happend? Don't try this yourself if you aren't a good athlete it will put you in the hospital if you don't keep yourself hydrated properly and monitor your heart rate.

I have been taking supplements(vitamins, herbal etc) for 30 years from legitimate suppliers including health food stores for health problems including the mysterious condition for several years which  I now know as POIS.  I bought from legitimate scources which have access to extensive research.  Even so I took some risks against the potential rewards and always began with minimal doses at first and built up gradually and have discarded many of them when I had negative side effects.   
I go into stores like GNC and pass by the products marketed for people who want to look like Arnold Shwartzeneger in a week or Be sex God and my inbox filters out about 300 e-mails a day selling these "magic pills from  a computer in their mother's basement. 
I nearly died from drugs(Vioxx) prescribed by some "highly respected' doctors.       
I would have to be "insane' to take something handed to me by some guys in a gym whose goal in life seems to be to win some competition and then die.    Especially with names like "Rocket Fuel" or "Animal cuts".
Caffeine can be Ok for most  people having a cup of coffee in the morning but concentrated scources such as Ephedra to lose weight or is very dangerous for the heart.  A bottle of something at the local convernience store counter is not a  sustitute for sufficient sleep and rest.     

Getting POIS is like getting the Flu.  The healthier you are the better your body can deal with it.  There aren't any magical quick fix pills or we wouldn't be here.

[monkeyboy]

well I totally apprecite that opinion. I was just sharing my experience and I'm not cured but I am a lot better. I hope you guys find something that gives you relief like I found. I have a feeling that whatever happend to me was a freak thing of parameters and conditions that you won't be able to repeat even if you took the same stuff I did. I still don't get why it made me better I could understand if it made me better for a few days but its been weeks and it hasnt changed at all.

[dbfd588]

well I totally apprecite that opinion. I was just sharing my experience and I'm not cured but I am a lot better. I hope you guys find something that gives you relief like I found. I have a feeling that whatever happend to me was a freak thing of parameters and conditions that you won't be able to repeat even if you took the same stuff I did. I still don't get why it made me better I could understand if it made me better for a few days but its been weeks and it hasnt changed at all.

I remeber someone posting who had a similar experience with 5 hour Energy I believe it was. They said they had a very severe headache and had a chalky urine discharge and it made them feel alot better. Im like you, Im not sure what happened but it would be nice to know.

[demografx]

I could understand if it made me better for a few days but its been weeks and it hasnt changed at all.

I was once very excited and thought I found a POIS cure with Levitra, but several months later it stopped working.

Over the last 4 years here at this forum, I have seen the same old drama playing out, almost like TV reruns.

I'm not trying to be a party pooper,  but I do suggest to give any POIS remedy a serious length of time trial.

Otherwise, you could set yourself up for crushing disappointment if and when it doesn't last.

[daveman]

The body has its natural hereditary limits. When I was younger I worked my way up to a 5 day split, worked 3 to 4 hrs per day 5 days a week, avoiding any one muscle group two days in a row.

I was happy with that and the results, although they weren't Mr. America results. But what I want to say is, as monkeyboy suggests, not just everybody can do these things, and even for me it took me 3 or 4 yrs to get to the 5 day split. And you know, I felt that it was all in control.

However, now, at 60+, I'm still suffering for some of the damage I did. And especially now that I have POIS those same injuries are exagerated. I didn't feel it at the time, but as I get older, some of the old stress points are very susceptible to damage.

So you have to be more than careful. Perhaps if you're NOT a regular body builder you're safer, because you're less likely to go overboard.

Just sayin'. If you need a boost, it's your body trying to tell you somthing.

These two cases of going beyond a limit and coming out the other side better........ don't match that well with anything I know about POIS.

Like you say, it would be interesting to know what's going on, and as both of you have histories of body/building (dbfd588 too right?), there must be something particular with that association too.

[demografx]

Posted at topix.com
http://m.topix.com/forum/health/allergy/T5DQV9OQBC6DBAUUG

poisperson | 6 hrs ago | Reply
Hi
Im in my early 30s and for over the last 10+ years have I been suffering bouts of fatigue, depression and muscular aches.
These bouts are triggered by an orgasm (which is somewhat embarrassing to admit).
It takes me about 5-7 days to recover from one, during which I feel tired or achy and miserable. The second and third day after an orgasm is the worst, where often I can feel ill or sometimes get a migraine. A week or two after one I feel good again.
Ive tried many different medications.
Abstinence is still the only preventative for me.
My symptoms seem identical to what is called ‘Post Orgasmic Illness Syndrome’
POIS was first described in 2002 by Dr.Marcel Waldinger a professor of sexual psychopharmacology at Utrecht University in Holland. 
Finally at start of 2011, Dr.Waldinger’s long-awaited study into POIS was published.It pointed to a semen allergy being the cause.
From press reports of the study:
For these studies, Waldinger and colleagues analyzed 45 Dutch men who were diagnosed with the illness.
33 of them agreed to undergo a standard skin-***** allergy test using a diluted form of their own semen. Of those, 29, or 88 percent, had a positive skin reaction indicating an auto-immune response, or allergic reaction.
In a second study in the same journal, Waldinger’s team decided to try treating two of the volunteers with hyposensitization therapy—a well-known technique for treating allergies, also called allergen immunotherapy, which repeatedly exposes the body to small but gradually increasing amounts of the allergen over several years. the men were given skin injections containing their own semen, at first in an extremely dilute form, and then in gradually less diluted forms. The study’s results showed that after one and three years respectively, the men showed a significant reduction in their POIS symptoms.
some of the POIS sufferers on the POIS forum have already tested positive to the Skin ***** test.
Women, of course, who are allergic to their partner’s semen, have been treated with immunotherapy for years this way.
One of the leading doctors on semen allergies, Dr. Jonathan Bernstein University of Cincinnati College of Medicine, has taken interest in this study and condition. He agrees men can be allergic to their own semen as semen is a foreign substance that can cause an immune system response in either the man's or woman's body.
He is not sure about the reliability of the skinprick test, he instead does a bloodtest to find which specific proteins his patients are allergic to, and produces a serum based on the specific protein. For women, he has had 90% success with a one-day desensitization treatment of 30 injections.
With his first male POIS patient, they are currently waiting results of a comprehensive test of the patient's human immune system including all mediators - IgE, IgM, IgG, and T-Cells
to see if theres a semen link, with the plans to have the one-day injection treatment done on the patient. 
I am looking to find an open, willing allergist to discuss my options, (but theres no semen allergy experts in UK that I am aware of.)
I
1) Simply, do you know how much a "comprehensive test of the patient's human immune system including all mediators - IgE, IgM, IgG, and T-Cells" costs in UK? It costs $2000 in america appararently
2) Is it possible to simply get this "comprehensive test" done and then getting going Sublingual Immunotherapy for ALL the proteins/allergens you prove to be allergic to? i.e can you get "SLIT" for multi-allergens?
This was an idea I had, sounds good to me, a UK doctor might not be able tell which is related to semen and which isnt, so surely dealing with them all is the best idea, assuming I am allergic to multi proteins. Even if Im not allergic to my semen then surely doing this would still boost my immune system, prehaps enough so the POIS will fade?
Sublingual therapy would be alot cheaper and practical for me 
3) any ideas/thoughts what avenue i should go..
many thanks

[MrMoonJr]

I went to my local urologist as part of my first step towards getting an anwser to my P.O.I.S and after sitting with him and discussing my problems, he told me he had come across it in the past and had studied some aspects of it and told me about Immune Privileges. Essentially there are some parts of the body that are protected by a barrier so the immune system can not create an auto immune reaction can not harm them. He told me, he believes in the case of POIS the testicles are lacking this barrier. newbielink:http://en.wikipedia.org/wiki/Immune_privilege#Testes [nonactive]  There is a website with more information. Check the "testes" portion of the website and please tell me your thoughts and ideas