[daveman]

Sumatriptan is structurally similar to serotonin (5HT), and is a 5-HT (types 5-HT1D and 5-HT1B[7]) agonist. The specific receptor subtypes it activates are present on the cranial arteries and veins. Acting as an agonist at these receptors, Sumatriptan reduces the vascular inflammation associated with migraine.

Is inflammation causing a run out of serotonin and then tryptophan and then vitamin B3 ?

B3 is also involved as a precursor in the histamine chain. And could well be like Victor says, if you have the pre-cursor and can't use it, the solution is one, but if you are low in production of the pre-cursor the solution is the other.

Diabetes is that way. There are two types of insulin, one in which the body lacks insulin, and another where the body has enough but doesn't know how to use it. Two completely different solutions, same final result.

So in POIS, I think that's what we are looking at.

It's incredible what we can do as lay-people, isn't it!!??

[demografx]

It is incredible, daveman!

[demografx]

"The Science of Orgasm" author responded to my inquiry about their recently published Rutgers University (NJ) study of fMRI's of female orgasm.

Dear Demografx,

Thank you for your interest in our research.  I have attached a copy of the poster that we presented.  The ipad on the poster contained the video of the fMRI animation of brain activity related to orgasm.  It can be viewed on You Tube.

Please let me know if you have questions or comments about our poster.

Barry R Komisaruk, Ph.D.

If anyone wishes to see the attached poster he presented, PM me your regular (@) email address. Demo.

I wrote back to thank Dr Komisaruk and to also ask if he can point us to any fMRI studies of MALE orgasm, or whether such studies are being contemplated.

My hunch is that male orgasm fMRI's could be a big breakthrough in POIS medical research.

[demografx]

He replied just now. To me, this is very exciting POIS news!!

Dear Demografx,

We are doing parallel [fMRI of Orgasm] studies in men currently.

Barry R. Komisaruk, Ph.D.

[daveman]

I'm looking forward to seeing the people at Hopkins and I will most definitely provide updates.  I wasn't too keen on cognitive behavioral therapy either, however, the neurologists tell me that the results actually alter the brain.  And that this is supported by functional MRI's.  Quite honestly, given that the Imitrex they have prescribed has provided much needed and unexpected relief, I am more than willing to follow their recommendations.

BY ALL MEANS. The important thing is that it's giving you a break from this "Hell", which I can totally relate to.

It's very exciting because it seems to have potential for adding another very solid link to the POIS puzzle.

[mellivora]

So....I was in a busy cafe with my laptop today and thought I could get away with checking poiscenter.com, expecting the usual innocuous homepage with poiscenter.com in tiny letters to appear. But no.....
Post Orgasmic Illness Syndrome (P.O.I.S.)

!!!!!!
Nice work on the new homepage Daveman thanks!  ( no seriously, its coming together well)
I did my best to look like a doctor who studies such things!

Thanks a lot for writing to Dr. Komisaruk Demo, great to know he is studying fMRI's in men and that we are in touch with him.

And pharoah its terrific to know you have got the attention of such a well qualified panel of experts.

[demografx]

So....I was in a busy cafe with my laptop today and thought I could get away with checking poiscenter.com, expecting the usual innocuous homepage with poiscenter.com in tiny letters to appear. But no.....
Post Orgasmic Illness Syndrome (P.O.I.S.)

!!!!!!

Nice work on the new homepage Daveman thanks!  ( no seriously, its coming together well)
I did my best to look like a doctor who studies such things!

Yes! It's shaping up GREAT! Thanks, daveman!!

[demografx]

[lauracostis]

Sumatriptan is structurally similar to serotonin (5HT), and is a 5-HT (types 5-HT1D and 5-HT1B[7]) agonist. The specific receptor subtypes it activates are present on the cranial arteries and veins. Acting as an agonist at these receptors, Sumatriptan reduces the vascular inflammation associated with migraine.

Is inflammation causing a run out of serotonin and then tryptophan and then vitamin B3 ?

B3 is also involved as a precursor in the histamine chain. And could well be like Victor says, if you have the pre-cursor and can't use it, the solution is one, but if you are low in production of the pre-cursor the solution is the other.

Diabetes is that way. There are two types of insulin, one in which the body lacks insulin, and another where the body has enough but doesn't know how to use it. Two completely different solutions, same final result.

So in POIS, I think that's what we are looking at.

It's incredible what we can do as lay-people, isn't it!!??

What they think happens in a migraine is that the vessels at the base of the head constrict, this causes the vessels higher up in the head to dilate as a compensatory mechanism to counteract for the decrease blood flow, this dilation causes the headache.  The triptians selectively bind to 5ht receptors and cause the dilated vessels in the upper head to constrict, which relieves the headache.  I get post-coital headaches and used to use sumatriptian, which worked great for the headaches and pois in general.  The only problem was that the more I used sumatriptian the less effective it became, I also started to get more and worse headaches from over use(rebound headaches).  Even if I did not get a postcoital headache, I would still take the sumatriptian and it would kick my pois in the ass pretty good.   I would recommend using the Imitrex sparingly to treat only your worst postcoital headaches.

[GoingCrazy]

What they think happens in a migraine is that the vessels at the base of the head constrict, this causes the vessels higher up in the head to dilate as a compensatory mechanism to counteract for the decrease blood flow, this dilation causes the headache.  The triptians selectively bind to 5ht receptors and cause the dilated vessels in the upper head to constrict, which relieves the headache.

Interesting, sounds exactly like my pois.  How it starts in the lower back of my head than slowly goes up towards the front.  I've been reading about imitrex and one post said something about the aspirin,caffeine combination, (excedrin migraine) and that actually helped more than the imitrex for the migraine.  But I definitely do want to try imitrex when I have symptoms.  POIS may be different than a migraine.

The only thing I need to find relief from is my restlessness after an O (my stage 1), I can't fall asleep and feel like I've been running a marathon throughout my sleep.  Stage 2 for me is like a rebound affect from stage 1, I can barely function, feel down.  Stage 2 is when excedrin migraine is most helpful.  But I'd like to find something for stage 1 since I already found a solution for stage 2.

[mrraba]

Relief of brain blockage in day one and two after O.  It helps a lot.  It is almost immediate.

newbielink:http://www.vitaglo.com/nr73500.html [nonactive]

Cheapest price i found. 

Have used it for years to unblock cognotive issues.  Helps with socializing, mood, etc.  It does tend to lower my sugar though and I feel the urge to eat animal protein.  I eat chiken.  It relieves the urge to eat after imuplus.  I do not recommed other brands.  They do not work for me.

Supposed to start slowly.  Like with 1/2 a packet.  See what it does for you. Initially getting some soreness under the arms is expected.   Immune system kind of kicks in.  It can make some allergies worse.

[demografx]

Thanks a lot for writing to Dr. Komisaruk Demo, great to know he is studying fMRI's in men and that we are in touch with him.

He's very much interested in studying POISers' vs non-POISers' Orgasm (before, during, after) - fMRI's of the brain.

We are discussing how to do this financially (Rutgers' fMRI's cost $300/hour). Maybe with NIH (through his leadership). Maybe through NORD? (He will be invited to submit a POIS Research proposal).

[martin88]

Thanks Martin. Omega3 caps (sardines and maquerels oil ? )didn't help me. I want to try astaxanthin but it's expansive

Same for me. In my case it can be the dosage: I took fish oil (sardines) containing 500mg DHA + 750MG EPA / teaspoon - I took 1/day==> no effect. I was far from the 2100mg DHA (+ phospholipids) in 150gr salmon. DHA is good for memory, increases serotonin, (prevents alzheimer?),... It should always be taken with anti-oxydants. Too much DHA is not good, I don't know the maximum dosage. It seems farmed salmon contains less astaxanthin than wild salmon.

[daveman]

Doctors are saying that vitamin D as in fish and other diet elements requires sunlight to fully integrate into the body.

Obviously excess must be avoided but they are saying we are tending to go to extremes that other way, especially with children.

In winter I think we should look for a source of ultra-violet, in combination with the high-D foods or even vitamin supplements. Maybe not necessary to develop a full tan, but one 5 min session per week.

Also, especially for those who are finding that niacin has little effect, try bolstering it with Vitamin-C and iron. These specifically help in the production of 5-htp which is a precursor to serotonin. And or if we are low in those elements could explain partly why niacin isn't working.

[daveman]

Can those who go to SMF go through the new main page?

Go to the page and bookmark it. It's one step more in getting there, but for one it helps our Google positioning (the most important) and anyways we will be adding more and more of interest to that page. Very shortly we will have surveys up and running and I want to add look and muscle to the database section.

Note the new URL is http://poiscenter.com/index.php  Note the PHP extension, not HTM.

[daveman]

There's a new SPAM filter incorporated into SMF. So this means that new members that are not on SPAMmers databases will be allowed in right away.

Great load off of me, but better for you as well, as you don't have to go through the approval phase.

If you apply and don't see yourself enabled right away, let me know here via PM and I'll get you through.

[daveman]

BTW, page content of the new WEB page is principally taken directly form posts on the SMF forum. Once every once and a while, (few days, week, not sure), posts will be selected that seem particularly key to our cause. These will be posted as "headline" on the  main page.

We obviously want to expose NSF here and the compendium too, but we don't have dynamic code access to be able to automatically extract posts.

We will be showing an dynamic updating list of all recent posts on the SMF forum too, for space reasons, it will show title date/hour and username. We ask that hopefully you can enter attractive and pertinent post subjects for all new posts instead of repeating the same title that is already there. Up to you though, if you want it to attract attention on the WEB page, something original is better.

We will be showing active members on the chat as well. As well as key article and poster references, breaking news in POIS land etc.

[badgerstripe]

I don't want to wait until late 2013 or 2014 before we can get dedicated (NORD-funded) POIS research under way. At the moment, that is the best we are heading for.  We've got 2 months to get to our NORD target this year and save ourselves from waiting this long.

We've had some very generous donations recently but some of these are to be made over a period of months. I'm certainly no less grateful to the donors for this fact but it does mean the current NORD pledge tally can be misleading as it uses the total that will be donated by 2013, not by March this year. We are still currently not in a good position to make the March deadline this year. To me it looks like we're half way at best.

After we reach our $33500 target, it'll likely be some months before a researcher is appointed to work on POIS through NORD. It may be some time after this that work finally begins. I believe I'm right in saying that we really need to make the March 2012 deadline (2 months time) if we're going to see any benefits from NORD funded research within the next two years. There isn't a quick fix. But it'll be quicker if we begin now. Also, things will cost more in years to come. $33500 might not be the minimum required in future years, it might be more.

 We have some things that help some of us (eg. Niacin, immunotherapy) at the moment. But these are not cures so far or 100% effective treatments. And we still don't know what causes POIS. We have much better theories than we used to and even evidence for some of them but all POIS sufferers are not the same and what works for some doesn't work for others. We need to push this if we're going to help everyone. We need to know what POIS is, what causes it, what varieties of POIS there are and use this to  get as close as possible to being cured/ being POIS-free. For us and for future sufferers.

2 months is all we have. So far I have pledged $500. On the condition that we make the March 2012 deadline, I'm upping my pledge to $1500. (seriously, no clappy applause gifs for this please, lets just get that total)

$50 just donated. lets hit that target!

[mellivora]

Fantastic badger, thankyou!

[mellivora]

Please check out my second post (Reply #21 on: January 22, 2012, 12:47:44 PM) on the following thread on poiscenter and read the replies that follow:

http://poiscenter.com/forums/index.php?topic=222.15


We'd like to soon try some fundraising for the NORD grant using the website reddit.com and would appreciate your suggestions based on the information provided by Nightingale, myself and CCconfucius on the poiscenter thread. Give us your ideas!