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1) Welcome Sohail! We're very happy that you found this forum. We really think and hope 2013 is the year that we can finally get some good research and solve this POIS problem once and for all!
Hi, We had a big discussion about histamine receptors over on poiscenter. There's some stuff here newbielink:http://poiscenter.com/forums/index.php?topic=795.30 [nonactive]. I think it's best not to post about new theories over there (as it's against the rules) but you could read the posts if you want. The h3 idea isn't new. H3 blockers aren't widely available. Alternatives are mast cell stabilisers. Just so you know, everyone releases histamine when there's an erection. When h2 blockers are given to someone, it impedes them getting an erection. That doesn't mean there's not an immunological reaction going on here but the question is why are POIS sufferers different rather than why do POIS sufferers have histamine release upon an O.
@kurtosis I'm so happy I found you're an INTJ. I'm really interested in personality psychology stuff.I'm an INTP-big5:RLUAI-enneagram:5.Do you think asking other members to take personality test is a good idea?I'm really curious if there is any correlation between personality type and pois.
These results indicate that histamine may play a role in human penile erection. The erection-promoting action of histamine is probably due to H2 receptor activation, although another histamine receptor, possibly H3, also seems to be involved. This study suggests that histamine could be a valuable tool in the diagnosis of erectile dysfunction.
While the H2 antagonists do not always have strong behavioural effects when administered peripherally, there is evidence that cimetidine has a depressant effect on sexual function
Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through a process called excitotoxicity. Excessive glutamate, or excitotoxins acting on the same glutamate receptors, overactivate glutamate receptors (specifically NMDARs), causing high levels of calcium ions (Ca2+) to influx into the postsynaptic cell.[34]High Ca2+ concentrations activate a cascade of cell degradation processes involving proteases, lipases, nitric oxide synthase, and a number of enzymes that damage cell structures often to the point of cell death.[35] Ingestion of or exposure to excitotoxins that act on glutamate receptors can induce excitotoxicity and cause toxic effects on the central nervous system.[36] This becomes a problem for cells, as it feeds into a cycle of positive feedback cell death.
ACRONYМ,What happened to me that I was stressed and for some stupid reason I started to take zinc also, and took it for a while. that is when my Pois started. it sped my thyroid relative to adrenal gland, and my dopamine which is associated with adrenal became lower than serotonin which was associated with thyroid. Basically the gap between dopamine and serotonin increased// To tell you the truth from the blood work that I saw , this is the imbalance in 90% cases/ So the cure for this imbalance is to lower your thyroid, and at the same time increase your methylation.
In response to Vincent M, H1 do not appear to be responsible for maintaining an erection. The h2 receptors in the penis are effected but histamine levels increase. Arguably not a problem for most people but it makes me itchy, sneezy and brings about something that feels like a headache that never quite develops. See http://www.ncbi.nlm.nih.gov/pubmed/7850330for a description of histamine's role in sexual function. QuoteThese results indicate that histamine may play a role in human penile erection. The erection-promoting action of histamine is probably due to H2 receptor activation, although another histamine receptor, possibly H3, also seems to be involved. This study suggests that histamine could be a valuable tool in the diagnosis of erectile dysfunction.The results appear conclusive but scientists are supposed to be cautious in what they say. This is generally considered a good thing There are other articles on ncbi about this also. http://www.ncbi.nlm.nih.gov/pubmed/3133686QuoteWhile the H2 antagonists do not always have strong behavioural effects when administered peripherally, there is evidence that cimetidine has a depressant effect on sexual function
Quote from: kurtosis on 08/01/2013 10:53:59In response to Vincent M, H1 do not appear to be responsible for maintaining an erection. The h2 receptors in the penis are effected but histamine levels increase. Arguably not a problem for most people but it makes me itchy, sneezy and brings about something that feels like a headache that never quite develops. See http://www.ncbi.nlm.nih.gov/pubmed/7850330for a description of histamine's role in sexual function. QuoteThese results indicate that histamine may play a role in human penile erection. The erection-promoting action of histamine is probably due to H2 receptor activation, although another histamine receptor, possibly H3, also seems to be involved. This study suggests that histamine could be a valuable tool in the diagnosis of erectile dysfunction.The results appear conclusive but scientists are supposed to be cautious in what they say. This is generally considered a good thing There are other articles on ncbi about this also. http://www.ncbi.nlm.nih.gov/pubmed/3133686QuoteWhile the H2 antagonists do not always have strong behavioural effects when administered peripherally, there is evidence that cimetidine has a depressant effect on sexual functionInteresting. I have taken ranitidine, an H2 receptor inverse agonist, with no effect on my erections. Perhaps I'd need something for the H3 receptor as well.
We allowed to post here if we keep it scientific. Keeping it scientific means providing evidence. If you did not just come up with this theory out of nowhere then you should past evidence you can easily provide. nobody is competing or trying to attack you, we just want evidence.