[thedoc (OP)]

@popupcamptrout asked the Naked Scientists:
   What's the MOA of aspirin? has it multiple targets? What does this say about robustness in genetic networks?
What do you think?

[exothermic]

Aspirin at 81mg/day reduces the risk of atherosclerotic coronary artery disease & stroke by reducing coronary vasoconstriction and enhancing coronary vasodilation.

Aspirin facilitates endothelial prostacyclin production & localized vasodilation via the blockade of platelet thromboxane a2 production.

The downregulation by aspirin of thromboxane-induced vasoconstriction is important in the context of the ischemic-mediated oxygen supply-and-demand imbalances and reduced blood flow observed in coronary artery disease.

~

 

[smart]

Aspirin is considered toxic at doses greater than 150mg per kg of body mass.

https://en.wikipedia.org/wiki/Aspirin_poisoning