[scientizscht (OP)]

Hello!

We know that high blood sugar results in the formation of AGEs (advanced glycation endproducts) by direct glycation which subsequently modify proteins and other biomolecules triggering disorders like atheromatosis etc.

Can anyone give me an overview of how this works exactly?

What happens with extra- and intra- cellular AGEs? I suppose high intracellular sugar and high extracellular sugar result in them?

What is the most important pathogenetic mechanism? Extra- or intra- cellular AGE formation?
As for endothelium damage, is it the intra- or extra- cellular AGEs responsible?

Thanks!