The Naked Scientists
  • Login
  • Register
  • Podcasts
      • The Naked Scientists
      • eLife
      • Naked Genetics
      • Naked Astronomy
      • In short
      • Naked Neuroscience
      • Ask! The Naked Scientists
      • Question of the Week
      • Archive
      • Video
      • SUBSCRIBE to our Podcasts
  • Articles
      • Science News
      • Features
      • Interviews
      • Answers to Science Questions
  • Get Naked
      • Donate
      • Do an Experiment
      • Science Forum
      • Ask a Question
  • About
      • Meet the team
      • Our Sponsors
      • Site Map
      • Contact us

User menu

  • Login
  • Register
  • Home
  • Help
  • Search
  • Tags
  • Recent Topics
  • Login
  • Register
  1. Naked Science Forum
  2. Life Sciences
  3. Cells, Microbes & Viruses
  4. Virus Membrane the weakest link?
« previous next »
  • Print
Pages: [1]   Go Down

Virus Membrane the weakest link?

  • 4 Replies
  • 3938 Views
  • 0 Tags

0 Members and 1 Guest are viewing this topic.

Offline Space99 (OP)

  • First timers
  • *
  • 1
  • Activity:
    0%
  • Naked Science Forum Newbie
Virus Membrane the weakest link?
« on: 26/04/2020 17:46:38 »
                     With regards to the Pandemic and Covid-19, would it be possible to try the following. My apologies at first, as Im autistic/ Aspergers so I see problems differently and probably wrong to.

                     I know that washing with soap, we are told dissolves the Virus Membrane. Is it not possible that the bodies own internal soap system, ie Fat dissolvers work to inactivate the Virus Envelope? In the form of 'Bile Salt Acids' From what I read, the Bile salts dissolve the Virus envelope, the same way it does gallstones.

                      I was looking at some info on the net, and found just one example..

      Virologists have known for almost 75 years that some viruses (conventional enveloped viruses such as the togaviruses) are readily inactivated by bile salts, whereas others (non-enveloped viruses such as poliovirus) are not [29].

                       I know I'm no expert but I have always wanted to do Virology type work when I left School. Unfortunately I never got do it, due to my autism hindering my grades too much. Despite this, I still like to self learn from the Net when i can as I find it fascinating. I just wondered if any further research on Bile Salts has gained any further results.

                       Much thanks!
Logged
 



Offline Bobolink

  • Sr. Member
  • ****
  • 170
  • Activity:
    0%
  • Thanked: 4 times
  • Naked Science Forum Newbie
Re: Virus Membrane the weakest link?
« Reply #1 on: 26/04/2020 18:06:21 »
Quote from: Space99 on 26/04/2020 17:46:38
 I know that washing with soap, we are told dissolves the Virus Membrane.
I didn't know that.  Did some quick research on it.  It really is quite interesting.  Thanks for that bit of information. 
I had assumed soap just helped rinse it away from your hands, I really suck at biology...
Logged
 
The following users thanked this post: Space99

Offline Bored chemist

  • Naked Science Forum GOD!
  • *******
  • 31101
  • Activity:
    13%
  • Thanked: 1291 times
Re: Virus Membrane the weakest link?
« Reply #2 on: 26/04/2020 18:13:32 »
It's quite likely that the bile salts would destroy the virus.
However, they are not in the right place, they are in the gut, not the lungs.
Also, they would probably damage lung cells just as much as they damage the virus.
It is extremely difficult to find things that do more harm to viruses than they do to the body.
Logged
Please disregard all previous signatures.
 
The following users thanked this post: Space99

Offline Colin2B

  • Global Moderator
  • Naked Science Forum King!
  • ********
  • 6476
  • Activity:
    0%
  • Thanked: 708 times
Re: Virus Membrane the weakest link?
« Reply #3 on: 26/04/2020 22:57:04 »
The virus ‘membrane’ of enveloped viruses is a lipid (like fat) which is why soap, ethanol etc attack it.
Although bile salts might be in the wrong place there are suggestions that other molecules might work eg https://www.ncbi.nlm.nih.gov/pubmed/32229155.
I haven’t read this yet so can’t vouch for the conclusions. Don’t know if @chris has a view?
Logged
and the misguided shall lead the gullible,
the feebleminded have inherited the earth.
 

Offline chiralSPO

  • Global Moderator
  • Naked Science Forum King!
  • ********
  • 3743
  • Activity:
    0%
  • Thanked: 531 times
Re: Virus Membrane the weakest link?
« Reply #4 on: 27/04/2020 15:40:25 »
I believe this is why the virus does not appear to be food-borne.

Though actually, I would say that the membrane is the virus's strongest link. My understanding is that the membrane is what helps it live for so long outside of an organism. Once the membrane is disrupted (by soap or organic solvent or corrosive agent), then the virus is without its armor, and quickly succumbs to the environment.

I suspect that the key to defeating this bug is going to be finding a way to block/slow down its mechanism of hijacking cells. It appears that the ACE2 receptors are the "back door" that the virus uses to get in, and that variations of this (genetic and/or epigenetic) may be responsible for the extreme difference in outcomes between individuals—according to what I have read over the last few weeks, it looks like 50+% of people are asymptomatic, and about 10% have extreme reactions including organ failure (lung, kidney, blood, etc.)

 https://www.cell.com/pb-assets/products/coronavirus/CELL_CELL-D-20-00739.pdf

Fortunately, ACE2 is very well-studied, and there are already multiple drugs that act on it. in some way or another. Unfortunately, ACE2 is also not something to be tinkered with lightly. Preventing viral replication is good, but not at the expense of a heart attack or stroke or other significant cardiovascular issues...

https://www.medicinenet.com/ace_inhibitors/article.htm#what_are_the_side_effects_and_adverse_event_of_ace_inhibitors
Logged
 



  • Print
Pages: [1]   Go Up
« previous next »
Tags:
 
There was an error while thanking
Thanking...
  • SMF 2.0.15 | SMF © 2017, Simple Machines
    Privacy Policy
    SMFAds for Free Forums
  • Naked Science Forum ©

Page created in 1.159 seconds with 40 queries.

  • Podcasts
  • Articles
  • Get Naked
  • About
  • Contact us
  • Advertise
  • Privacy Policy
  • Subscribe to newsletter
  • We love feedback

Follow us

cambridge_logo_footer.png

©The Naked Scientists® 2000–2017 | The Naked Scientists® and Naked Science® are registered trademarks created by Dr Chris Smith. Information presented on this website is the opinion of the individual contributors and does not reflect the general views of the administrators, editors, moderators, sponsors, Cambridge University or the public at large.