The Naked Scientists
  • Login
  • Register
  • Podcasts
      • The Naked Scientists
      • eLife
      • Naked Genetics
      • Naked Astronomy
      • In short
      • Naked Neuroscience
      • Ask! The Naked Scientists
      • Question of the Week
      • Archive
      • Video
      • SUBSCRIBE to our Podcasts
  • Articles
      • Science News
      • Features
      • Interviews
      • Answers to Science Questions
  • Get Naked
      • Donate
      • Do an Experiment
      • Science Forum
      • Ask a Question
  • About
      • Meet the team
      • Our Sponsors
      • Site Map
      • Contact us

User menu

  • Login
  • Register
  • Home
  • Help
  • Search
  • Tags
  • Recent Topics
  • Login
  • Register
  1. Naked Science Forum
  2. Life Sciences
  3. Physiology & Medicine
  4. COVID-19
  5. Could a lab mutated version of CoV2 combat the virus?
« previous next »
  • Print
Pages: [1]   Go Down

Could a lab mutated version of CoV2 combat the virus?

  • 1 Replies
  • 1912 Views
  • 0 Tags

0 Members and 2 Guests are viewing this topic.

Offline set fair (OP)

  • Sr. Member
  • ****
  • 467
  • Activity:
    1.5%
  • Thanked: 19 times
  • Naked Science Forum Newbie
Could a lab mutated version of CoV2 combat the virus?
« on: 23/12/2020 18:27:30 »
I'm thinking of perhaps deleting the  furin cleavage site and one or more of the helper proteins, such as the one which enters the nucleus and turns off the alarm (preventing the presentation of viral proteins, the warning of adjacent cells and self destruction). Then seeding it in the population.

Could the Chinese have done this?
« Last Edit: 24/12/2020 14:36:01 by set fair »
Logged
 



Offline set fair (OP)

  • Sr. Member
  • ****
  • 467
  • Activity:
    1.5%
  • Thanked: 19 times
  • Naked Science Forum Newbie
Re: Could a lab mutated version of CoV2 combat the virus?
« Reply #1 on: 24/12/2020 15:40:20 »
I edited the original post to include furin cleavage site.

From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457603/

Quote
SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world. Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin cleavage site (PRRAR) in its spike protein. Absent in other group 2B CoVs, the insertion may be a key factor in the replication and virulence of SARS-CoV-2. To explore this question, we generated a SARS-CoV-2 mutant lacking the furin cleavage site (ΔPRRA) in the spike protein. This mutant virus replicated with faster kinetics and improved fitness in Vero E6 cells. The mutant virus also had reduced spike protein processing as compared to wild-type SARS-CoV-2. In contrast, the ΔPRRA had reduced replication in Calu3 cells, a human respiratory cell line, and had attenuated disease in a hamster pathogenesis model. Despite the reduced disease, the ΔPRRA mutant offered robust protection from SARS-CoV-2 rechallenge.


Looks like this might be a candidate.

If China has done this, there should be a tell tale signature in antibodies produced. It would explain why they aren't rolling out sinovac across the country.
« Last Edit: 24/12/2020 15:51:18 by set fair »
Logged
 



  • Print
Pages: [1]   Go Up
« previous next »
Tags:
 
There was an error while thanking
Thanking...
  • SMF 2.0.15 | SMF © 2017, Simple Machines
    Privacy Policy
    SMFAds for Free Forums
  • Naked Science Forum ©

Page created in 0.307 seconds with 25 queries.

  • Podcasts
  • Articles
  • Get Naked
  • About
  • Contact us
  • Advertise
  • Privacy Policy
  • Subscribe to newsletter
  • We love feedback

Follow us

cambridge_logo_footer.png

©The Naked Scientists® 2000–2017 | The Naked Scientists® and Naked Science® are registered trademarks created by Dr Chris Smith. Information presented on this website is the opinion of the individual contributors and does not reflect the general views of the administrators, editors, moderators, sponsors, Cambridge University or the public at large.