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I would think it would depend a lot on the antibiotic. For example, a natural antibiotic such as Penicillin is found in molds, and the kinds of things that a scavenger might eat, so it might not be surprising to find Penicillin resistant flora in the sharks.However, for other types of antibiotic resistance, one would have to come up with a plausible mechanism for it to enter the shark's food chain.For example. If a fish farm fed salmon smolt antibiotics, then the salmon might develop antibiotic resistant bacteria. Then, if these smolt were released into the ocean, sharks might eat the fish and be colonized by antibiotic resistant salmon bacteria. Through the wonders of plasmids and gene transference, some shark flora might also pick up the resistance genes even though there might be little selective pressure to maintain these genes.Another mechanism might be the release of untreated human sewage into rivers, streams, and the ocean carrying antibiotic resistant bacteria which could then colonize fish, and eventually colonize sharks. It should be possible to determine if the specific bacteria carrying the resistance began as human flora.Many types of antibiotics are not found in the natural environment, and thus it would be unlikely that resistance to these antibiotics would develop without human involvement.The reality is that this poses little danger to the sharks themselves, but could eventually lead back to us in that standard antibiotics could loose effectiveness. Most of the multi-drug resistant bacteria are limited to the hospital setting, but eventually might increase in prevalence outside of the hospital setting. The use of things such as antibacterial soaps should be limited only to those few situations where they are required.