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Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S....AbstractObjective: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and the second most common cause of mortality in children aged 1–14 years. Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL.Cancer Causes Control. 2004 Aug;15(6):559-70. http://www.springerlink.com/content/t87661x864l14368/fulltext.pdf
I meant to discuss about Evidence Based Medicine or Patient Oriented Decisions...It's about whether to strongly and officially recommend a nontoxic nutrient when data to prove its efficacy are still unconfirmed.In the case of a disease of unknown cause and poor treatment results (2/3)...unsatisfactory results, or 'suboptimal' if you prefer.It's Philosophy of Science and practical medicine altogetherikod [^] thanks to the >100000 viewers!
Quote from: dqfry on 28/11/2007 17:14:36I can't tell you how many times I've came back to this topic and read postings over and over. I still haven't read it all yet! I can only thank you for being here and for sharing your knowledge and thoughts."A little knowledge that acts is worth infinitely more than much knowledge that is idle."Kahlil GibranThank you dqfry!This thread started with a question for young scientists and open-minded medical students*:QuoteIs vitamin D deficiency in childhood leukaemia an underestimated reality?Could cod liver oil - the old remedy, a relic from the past - help in theempirically arranged but clinically effective today's treatment protocols? The aim was to make some smart girl/boy cross "cod liver oil" and "leukemia" on PubMed database and find the old 1988 "Shanghai report".Then we would have discussed the opportunity to give some "cod" to leukemic patients.Your totally unexpected, dramatic, precious contribution fixed the limits of this issue, proving, at the same time, that our message is reachable by parents and patients.They are -in the end- the real target of this topic.ikod*a young scientist! http://t2.gstatic.com/images?q=tbn:f_8eZbUquaFsEM:http://www.uwosh.edu/science_outreach/kid%20microscope.jpghttp://blog.cerbero.eu/wp-content/uploads/2007/09/message-in-a-bottle.jpghttp://annietv600.files.wordpress.com/2006/11/journal_reading.thumbnail.gif
I can't tell you how many times I've came back to this topic and read postings over and over. I still haven't read it all yet! I can only thank you for being here and for sharing your knowledge and thoughts."A little knowledge that acts is worth infinitely more than much knowledge that is idle."Kahlil Gibran
Is vitamin D deficiency in childhood leukaemia an underestimated reality?Could cod liver oil - the old remedy, a relic from the past - help in theempirically arranged but clinically effective today's treatment protocols?
We know from the 'Shanghai report' that daily doses of vitamins A and D (actually cod liver oil!) -taken for at least one year- could be able to reduce leukemia incidence to half or 1/3.It's not much, but we (parents) should give it a chance and offer this protection to our sick children, to avert relapse risk.
"Now every evening, everywhere in the world, some parentis reminding one of the kids to take his 'cod'." one parent's dream
Vitamin D insufficiency in the pediatric oncology population:defining who is at risk and the need for standardized screening. M. A. Helou, G. Massey, G. Francis, K. Godder, J. Laver Abstract: Background: Survivors of childhood cancer are at increased risk for osteoporosis. Contributing factors include direct effects of chemotherapy and radiation therapy on bone, secondary hormone deficiencies, and chronic illness. However, vitamin D insufficiency could be a major risk factor during and after cancer therapy. Vitamin D insufficiency is common in healthy school aged children (median 25-hydroxy vitamin D [25(OH)D] = 28 ng/mL, 55% <30 ng/mL, 5% < 10 ng/mL.) Based on this data, we hypothesize that vitamin D insufficiency would be common among children with cancer. If vitamin D insufficiency is prevalent, correction may contribute to better bone health and immune responses in children with cancer. Methods: We determined the serum levels of 25(OH)D, PTH, calcium, and phosphorus for 40 children with leukemia or lymphoma currently on therapy (group 1), 34 children with leukemia or lymphoma off therapy (group 2), 16 children with solid tumors currently on therapy (group 3), and 10 children with solid tumors off therapy (group 4.) Prevalence of 25(OH)D insufficiency ( <32 ng/mL) and severe deficiency (<10 ng/mL) was compared by Chi square test to the healthy reference population (established by Weng, et al.)Results: For the majority of patients, calcium and phosphorus levels were within normal limits. Conclusions: Vitamin D insufficiency was very common in all groups, especially in children with solid tumors on therapy (Group 3.) 25(OH)D levels did improve off therapy, but for Group 2, still remained significantly less than normal reference population (p=0.0001.)The data suggests that vitamin D status should be determined for all children at diagnosis of malignancy with a strong recommendation to consider vitamin D supplementation during treatment and follow up. J Clin Oncol 26: 2008 (May 20 suppl; abstr 10023)
Unfortunately, if vitamin D is needed mainly, and too much vitamin A is either toxic or counteracting "D" wonderful effects (J.Cannell et al. Nov.2008), we would need a special cod liver oil formula:a moderate amount of vitamin A, plenty of D-vitamin and lots of omega-3! This probably WAS the original cod liver oil, before they started removing D-vitamin, erroneously thinking that it was too close to toxic amounts. Two thousands I.U. per day of vitamin D3 were considered almost toxic for humans.What a shame: we seem to have destroyed the original formula.
It could take more than a human life to read everything about human leukaemia, but a few basic answers are still missing... http://www.heathersanimations.com/babies/animated_baby.gif many others plus me
I am not at all sure there is a single cause of leukaemia – why should there be only one cause?I think it is fairly certain that some leukaemias are caused by viral infections.another someone
"We had been studying those cells in a bottle for too long,and forgot to have a look at the original container..." Anonymous
Quote from: iko on 26/11/2008 14:03:59Quote from: iko on 21/07/2007 12:54:35Quote from: iko on 19/10/2006 09:05:56Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg "Il sole dona la vita, il sole se la riprende" Mario Umberto Dianzani, 1975.
Quote from: iko on 21/07/2007 12:54:35Quote from: iko on 19/10/2006 09:05:56Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg "Il sole dona la vita, il sole se la riprende" Mario Umberto Dianzani, 1975.
Quote from: iko on 19/10/2006 09:05:56Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg "Il sole dona la vita, il sole se la riprende" Mario Umberto Dianzani, 1975.
Thank you Zoey,for asking about my favourite quote. Well, to explain it properly, in a short 'essay' in english... it will take me more than a few minutes! But translating it is the easiest thing:"The sun gives life, the sun takes it back" These words concluded one of the best lectures I attended in my life. At the 3rd year of Medical school, General Pathology course, more than thirty years ago. Professor Mario Umberto Dianzani was our teacher, Dean of the Medical Faculty and a distinguished scientist, totally dedicated to his students. Later on he has been Rector of the University of Turin for several years before retiring.In those days biochemistry was 'the' thing: new cofactors and vitamins were deeply explored by medical research.I'm sure I owe to his excellent lectures my following research interest in cofactors."Aging of cells and living organisms" was the subject of the lecture.In less than one hour we went from the origin of life on our Planet to the present time.Volcanoes and oceans plus UV light to catalyze the synthesis of organic compounds (Miller's experiment), then nucleic acid formation after million years of random combinations.Primitive organisms, bacteria and algae. Again the sunlight creates energy through photosynthetic processes and here come trees and forests! Different species of primitive life, unicellular, multicellular towards more and more complex organisms, thanks to spontaneous mutations, natural selection and evolution. For the whole 'biosphere' survival is always tightly bound to its origin, to the sunlight.Sunlight and ultraviolet rays give energy and feed the whole system, nevertheless they are responsible -in the end- for lipid peroxidation and DNA damage. A series of biochemical reactions lead to senescence in multicellular organisms too.Complex systems are progressively deranged: skin, bones, muscles, nerves, glands and immune cells get older...diseases follow.The sun itself puts an end to our lives.Magic... http://blogs.bootsnall.com/Chuck/uploads/_Beautiful%20Sunrise.jpg
Paradoxical results are not uncommon in studies of carcinogenesis. Ignoring these paradoxes is tantamount to saying the prevailing theory holds in all instances except the paradoxycal cases. However ignoring "outliers" in data analysis is not satisfying; it should be the last refuge when all else fails.But more importantly, ignoring paradoxycal results means missing potentially exciting new avenues for research.Rather than relegate the paradoxycal results to the periphery of investigations, they should be the centerpiece of a paradox-driven research portfolio.Summary in: "Paradoxes in carcinogenesis: New opportunities fo research directions."Stuart G Baker and Barnett S KramerBMC Cancer 2007, 7:151this article is available from: http://www.biomedcentral.com/1471-2407/7/151
Bessis Marcel (1917-1994) Inserm actualités 1994Marcel Bessis vient de nous quitter. De la campagne d'Italie à la première rémission des leucémies aiguës, tel pourrait être le titre du chapitre initial de l'oeuvre de Marcel Bessis. C'est pendant la campagne d'Italie qu'il avait proposé de traiter les blessés victimes de graves écrasements musculaires par le grand échange du sang, l'exsanguino-transfusion. C'est à l'hôpital Saint-Antoine que, un des tout premiers, il traite par l'exsanguino-transfusion les nouveau-nés victimes de la maladie hémolytique par conflit Rhésus. D'où de pénétrantes études sur cette maladie du nouveau-né qu'il reproduit chez le raton, qu'il retrouve chez le muleton du Poitou, victime des anticorps anti-baudet sécrétés par la mère jument. C'est enfin, en novembre 1947, à l'hôpital Herold, pour la première fois dans l'histoire des leucémies, la rémission complète d'une leucémie aiguë obtenue par l'exsanguino-transfusion, début d'un long combat. Cependant, Marcel Bessis, se consacrant entièrement au laboratoire, devenait le pionnier des nouvelles méthodes microscopiques. Il applique la microscopie électronique à l'étude des structures des cellules sanguines normales et leucémiques. Il reconnaît, décrit des formes, des structures nouvelles. Surtout, il met au point la microcinématrographie accélérée en contraste de phase. Il passe de l'anatomie à la physiologie. Il crée littéralement l'écologie, l'éthologie des cellules sanguines, reconnaissant les informations qui couvent à l'intérieur de la cellule, d'organelle en organelle, de mitochondries en centriole. C'est ainsi qu'on lui doit la première description du nécrotaxis, de cette mort cellulaire qui inspire actuellement de nombreux travaux. Marcel Bessis, comme les grands hommes de sciences, a su constamment allier la rigueur technique à une réflexion générale philosophique dont témoignent des essais sur l'histoire de la recherche scientifique, la créativité dans l'art et la science, la définition du soi et du non-soi. Cette oeuvre, très étroitement liée à celle des chercheurs de l'Inserm, a été accomplie à l'Institut de pathologie cellulaire de l'hôpital de Bicêtre, puis au Centre d'écologie des cellules du sang à la Salpêtrière. Membre de nombreuses académies et sociétés savantes étrangères, Marcel Bessis avait été élu en 1979 membre de l'Académie des Sciences. Professeur Jean Bernard http://infodoc.inserm.fr/histoire/Histoire.nsf/(WWWReponses)/5AFB06BDC8B13BE480256DCC004EBFBF?OpenDocument&Infos
When IT strikes back it's a real tragedy for patients and parents.They suddenly realize why doctors were never totally relaxed during their regular checkups, even months and years from stop-therapy. The invisible enemy is back and nobody seems to know why, as it was at the very beginning of their illness. Girls and boys have grown up and forgotten about those awful days, such a long time has past, wasted without anything specific to do or even try, to avoid all this mess coming back again.Something should be done for these people.Quick.
We know from the 'Shanghai report' that daily doses of vitamins A and D (actually cod liver oil!) -taken for at least one year- could be able to reduce leukemia incidence to half or 1/3.It's not much, but we (parents) should give it a chance and offer this protection to our sick children, trying to avert relapse risk.
Parents do not need to ask a doctor or get a recipe before giving orange juice and/or cod liver oil to their children, either they are healthy or sick.iko
...why sitting in the sun can cause cancer.lotusbunny