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Diseases are the usual way great civilizations have ended. But in all likely hood it would be water radiation poisoning from Fukushima or any others that may occur.
I think that the nuclear accidents in the Ukraine and Japan caused very little damage on a worldwide scale but the minor accident at Three mile island will be the cause of an untold number of deaths due to delaying the introduction of nuclear power with the contamination caused by fossil fuel continuing.
As the expansion of the universe, the earth will also expand until it explode and there couldn't hold any life. Waaah, I'm not so lucky to see this spectacle.
What will cause the end of life on planet Earth? Will it be the when the sun dies or something else?
I think it's fair to say, though, that humans are probably the best prospect for global destruction, one way or another. Until we came along, life here had survived armageddon more than once. We're doing an excellent job of ruining the place for everything and everyone and creating a huge human monoculture in the process...
There are a lot of bad genes in people because rape and pillage was a major part in our evolutionary history with the bad guys winning repeatedly. It's really quite remarkable that so many people are nice and civilised despite that. What we need to do is reprogram all the bad stuff out of our species so that we no longer have any abusive individuals spoiling it for the rest. Once that's done, we have billions of years ahead of us here where we are no longer a negative thing.