[thedoc (OP)]

Peter Palmer asked the Naked Scientists:
   
Since both DNA strands have a 3' end, and I know of no means a cell can differentiate sense from anti-sense, (other than potentially distance to the centromere), is there a reason a reverse complement incorporating the combined promoter and starter sequences is unlikely, in order to avoid spurious primary transciptions?

What do you think?

[evan_au]

Reading complementary DNA is likely to end up hitting a "STOP" codon fairly quickly?
...But this would still leave a lot of short junk RNA sequences floating around...